(data stored in ACNUC18858 zone)

HOGENOM: MOUSE9_PE1443

ID   MOUSE9_PE1443                        STANDARD;      PRT;   437 AA.
AC   MOUSE9_PE1443; Q5JCT0; A2TIK7; Q8VCX9; Q9D8A3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Beta-1,3-galactosyl-O-glycosyl-glycoprotein
DE   beta-1,6-N-acetylglucosaminyltransferase 3; EC=2.4.1.102; EC=2.4.1
DE   150;AltName: Full=C2GnT-mucin type; Short=C2GnT-M;AltName:
DE   Full=Mucus-type core 2 beta-1,6-N-acetylglucosaminyltransferase;
DE   (MOUSE9.PE1443).
GN   Name=Gcnt3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSE9.PE1443.
CC       Mus musculus chromosome 9 NCBIM37  sequence 1..124076172 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:GCNT3_MOUSE
CC   -!- FUNCTION: Glycosyltransferase that can synthesize all known mucin
CC       beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan
CC       branching, 2 important steps in mucin-type biosynthesis. Has also
CC       I-branching enzyme activity by converting linear into branched
CC       poly-N-acetyllactosaminoglycans, leading to introduce the blood
CC       group I antigen during embryonic development (By similarity).
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-
CC       galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-
CC       galactosaminyl-R.
CC   -!- CATALYTIC ACTIVITY: UDP-N-acetyl-D-glucosamine + beta-D-
CC       galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-
CC       glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R.
CC   -!- PATHWAY: Protein modification; protein glycosylation.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type
CC       II membrane protein (By similarity).
CC   -!- PTM: N-glycosylated (By similarity).
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 14 family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH18297.1; Type=Erroneous initiation;
CC       Sequence=BAB25548.1; Type=Erroneous termination; Positions=35; Note=Translated as Cys;
CC   -!- WEB RESOURCE: Name=Functional Glycomics Gateway - GTase; Note=core
CC       2 beta 6 GlcNAc T3;
CC       URL="http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_mou_575";
CC   -!- GENE_FAMILY: HOG000293251 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000032226;ENSMUST00000034751;ENSMUSP00000034751.
DR   EMBL; AK008234; - ;
DR   EMBL; AY039027; - ;
DR   EMBL; BC018297; - ;
DR   EMBL; EF202835; - ;
DR   UniProtKB/Swiss-Prot; Q5JCT0; A2TIK7; Q8VCX9; Q9D8A3; -.
DR   EMBL; AY039027; AAK72480.1; -; mRNA.
DR   EMBL; EF202835; ABM91120.1; -; mRNA.
DR   EMBL; AK008234; BAB25548.1; ALT_SEQ; mRNA.
DR   EMBL; BC018297; AAH18297.1; ALT_INIT; mRNA.
DR   IPI; IPI00111289; -.
DR   RefSeq; NP_082363.2; NM_028087.2.
DR   UniGene; Mm.195555; -.
DR   ProteinModelPortal; Q5JCT0; -.
DR   SMR; Q5JCT0; 62-432.
DR   STRING; Q5JCT0; -.
DR   CAZy; GT14; Glycosyltransferase Family 14.
DR   PRIDE; Q5JCT0; -.
DR   Ensembl; ENSMUST00000034751; ENSMUSP00000034751; ENSMUSG00000032226.
DR   GeneID; 72077; -.
DR   KEGG; mmu:72077; -.
DR   UCSC; uc009qnt.1; mouse.
DR   CTD; 9245; -.
DR   MGI; MGI:1919327; Gcnt3.
DR   eggNOG; maNOG07131; -.
DR   GeneTree; ENSGT00550000074330; -.
DR   InParanoid; Q5JCT0; -.
DR   OMA; GQNSMES; -.
DR   OrthoDB; EOG4X6C8B; -.
DR   NextBio; 335378; -.
DR   ArrayExpress; Q5JCT0; -.
DR   Bgee; Q5JCT0; -.
DR   CleanEx; MM_GCNT3; -.
DR   Genevestigator; Q5JCT0; -.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0047225; F:acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IDR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IEDR   GO; GO:000

8109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; IEA:EC.
DR   GO; GO:0003829; F:beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity; IEDR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; IEA:EC.
DR   GO; GO:0008109; F:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity; IEA:EC.
DR   GO; GO:0002426; P:immunoglobulin production in mucosal tissue; IMP:MGI.
DR   GO; GO:0050892; P:intestinal absorption; IMP:MGI.
DR   InterPro; IPR003406; Glyco_trans_14.
DR   Pfam; PF02485; Branch; 1.
DR   HOGENOMDNA; MOUSE9.PE1443; -.
KW   ENSMUSG000000322265old_1320000031; ENSMUSP000000347511old_1320000031;
KW   AK008234; AY039027; BC018297; EF202835;
KW   Complete proteome; Disulfide bond; Glycoprotein; Glycosyltransferase;
KW   Golgi apparatus; Membrane; Reference proteome; Signal-anchor;
KW   Transferase; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   437 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTSWQRLCWH YRLWTLGCYM LLAILALKLS LRLKCDFDAM DLDSEEFQSQ YCRDLLYKTL
     KLPAKSSINC SGVIRGEQKA VTQALLNNLE IKKKQQLFTE ADYLRMTADC EHFKTKRKFI
     QVPLSKEEAS FPIAYSMVVH EKIENFERLL RAVYTPQNVY CVHMDQKSSE PFKQAVRAIV
     SCFPNVFIAS KLVSVVYASW SRVQADLNCM EDLLQSPVPW KYLLNTCGTD FPIKTNAEMV
     KALKLLKGQN SMESEVPPPH KKSRWKYHYE VTDTLHMTSK RKTPPPNNLT MFTGNAYMVA
     SRDFIEHVFS NSKARQLIEW VKDTYSPDEH LWATLQRASW MPGSDPLHRK FDLSDMRAIA
     RLTKWYDHEG DIENGAPYTS CSGIHQRAVC VYGSGDLHWI LQNHHLLANK FDPKVDDNVL
     QCLEEYLRHK AIYGTEL
//

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