(data stored in ACNUC18859 zone)

HOGENOM: MOUSEX_PE1549

ID   MOUSEX_PE1549                        STANDARD;      PRT;   580 AA.
AC   MOUSEX_PE1549; Q8BIQ5; A2AEJ9; A2AEK0; Q8K1Y6; Q9ERC2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Cleavage stimulation factor subunit 2;AltName: Full=CF-1 64
DE   kDa subunit;AltName: Full=Cleavage stimulation factor 64 kDa subunit;
DE   Short=CSTF 64 kDa subunit; Short=CstF-64; (MOUSEX.PE1549).
GN   Name=Cstf2;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSEX.PE1549.
CC       Mus musculus chromosome X NCBIM37  sequence 1..166650296 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:CSTF2_MOUSE
CC   -!- FUNCTION: One of the multiple factors required for polyadenylation
CC       and 3'-end cleavage of mammalian pre-mRNAs. This subunit is
CC       directly involved in the binding to pre-mRNAs (By similarity).
CC   -!- SUBUNIT: The CSTF complex is composed of CSTF1 (50 kDa subunit),
CC       CSTF2 (64 kDa subunit) and CSTF3 (77 kDa subunit). CSTF2 directly
CC       interacts with CSTF3, SYMPK and RPO2TC1. Interacts with HSF1 in
CC       heat-stressed cells (By similarity). Interacts with CPSF2, CPSF3
CC       and FIP1L1. Interacts with DDX1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Note=Localized with DDX1 in
CC       cleavage bodies (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8BIQ5-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8BIQ5-2; Sequence=VSP_014844, VSP_014845;
CC         Note=No experimental confirmation available;
CC   -!- TISSUE SPECIFICITY: Expressed in most somatic cell types (at
CC       protein level). Highly expressed in testis, except in meiotic
CC       spermatocytes.
CC   -!- INDUCTION: Up-regulated during the G to S phase transition.
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 RRM (RNA recognition motif) domain.
CC   -!- GENE_FAMILY: HOG000214373 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000031256;ENSMUST00000033609;ENSMUSP00000033609.
DR   EMBL; AF317552; - ;
DR   EMBL; AK032817; - ;
DR   EMBL; AK088260; - ;
DR   EMBL; AL671915; - ;
DR   EMBL; BC036719; - ;
DR   UniProtKB/Swiss-Prot; Q8BIQ5; A2AEJ9; A2AEK0; Q8K1Y6; Q9ERC2; -.
DR   EMBL; AF317552; AAG31814.1; -; mRNA.
DR   EMBL; AK032817; BAC28037.1; -; mRNA.
DR   EMBL; AK088260; BAC40243.1; -; mRNA.
DR   EMBL; AL671915; CAM16728.1; -; Genomic_DNA.
DR   EMBL; AL671915; CAM16729.1; -; Genomic_DNA.
DR   EMBL; BC036719; AAH36719.1; -; mRNA.
DR   IPI; IPI00457575; -.
DR   IPI; IPI00607981; -.
DR   RefSeq; NP_573459.1; NM_133196.5.
DR   UniGene; Mm.67938; -.
DR   ProteinModelPortal; Q8BIQ5; -.
DR   SMR; Q8BIQ5; 8-164, 532-580.
DR   STRING; Q8BIQ5; -.
DR   PhosphoSite; Q8BIQ5; -.
DR   REPRODUCTION-2DPAGE; IPI00607981; -.
DR   PRIDE; Q8BIQ5; -.
DR   Ensembl; ENSMUST00000033609; ENSMUSP00000033609; ENSMUSG00000031256.
DR   Ensembl; ENSMUST00000113286; ENSMUSP00000108911; ENSMUSG00000031256.
DR   GeneID; 108062; -.
DR   KEGG; mmu:108062; -.
DR   UCSC; uc009ufi.1; mouse.
DR   UCSC; uc009ufj.1; mouse.
DR   CTD; 1478; -.
DR   MGI; MGI:1343054; Cstf2.
DR   GeneTree; ENSGT00550000074641; -.
DR   InParanoid; Q8BIQ5; -.
DR   OMA; HVPGHES; -.
DR   OrthoDB; EOG4640BW; -.
DR   PhylomeDB; Q8BIQ5; -.
DR   NextBio; 359962; -.
DR   ArrayExpress; Q8BIQ5; -.
DR   Bgee; Q8BIQ5; -.
DR   CleanEx; MM_CSTF2; -.
DR   Genevestigator; Q8BIQ5; -.
DR   GermOnline; ENSMUSG00000031256; Mus musculus.
DR   GO; GO:0071920; C:cleavage body; ISS:UniProtKB.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; ISS:UniProtKB.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait.
DR   InterPro; IPR000504; RRM_dom.
DR   Gene3D; G3DSA:3.30.70.330; a_b_plait_nuc_bd; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SMART; SM00360; RRM; 1.
DR   PROSITE; PS50102; RRM; 1.
DR   HOGENOMDNA; MOUSEX.PE1549; -.
KW   ENSMUSG000000312565old_1320000031; ENSMUSP000000336091old_1320000031;
KW   AF317552; AK032817; AK088260; AL671915; BC036719;
KW   Acetylation; Alternative splicing; Complete proteome; mRNA processing;
KW   Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.
SQ   SEQUENCE   580 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGLPVRDPA VDRSLRSVFV GNIPYEATEE QLKDIFSEVG PVVSFRLVYD RETGKPKGYG
     FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE LKSLGTGAPV IESPYGESIS
     PEDAPESISK AVASLPPEQM FELMKQMKLC VQNSPQEARN MLLQNPQLAY ALLQAQVVMR
     IVDPEIALKI LHRQTNIPTL ISGNPQPVHV AGPGSGPNVS MNQQNPQAPQ AQSLGGMHVN
     GAPPMMQASM PGGVPAPVQM AAAVGGPGPG SLAPAGVMQA QVGMQGAGPV PMERGQVPMQ
     DPRAAMQRGA LPTNVPTPRG LLGDAPNDPR GGTLMTVTGD VEPRAYLGPP PPPHQGPPMH
     HVPGHEGRGP PPHDMRGGPL AEPRPLMAEP RGPMLDQRGP PLDARGGRDP RGLDARGMEA
     RAMEARGLDA RGLEARAMEA RAMEARAMEA RAMEARAMEA RAMEARGMDT RGPVPGPRGP
     MPSGIQGPNP MNMGAVVPQG SRQVPVMQGA GMQGASMQGG SQPGGFSPGQ SQVTPQDHEK
     AALIMQVLQL TADQIAMLPP EQRQSILILK EQIQKSTGAP
//

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