(data stored in ACNUC7421 zone)

HOGENOM: MOUSEX_PE244

ID   MOUSEX_PE244                         STANDARD;      PRT;   662 AA.
AC   MOUSEX_PE244; Q62167; O09060; O09143;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ATP-dependent RNA helicase DDX3X; EC=3.6.4 13;AltName:
DE   Full=D1Pas1-related sequence 2;AltName: Full=DEAD box RNA helicase DEAD3;
DE   Short=mDEAD3;AltName: Full=DEAD box protein 3, X-chromosomal;AltName:
DE   Full=Embryonic RNA helicase; (MOUSEX.PE244).
GN   Name=Ddx3x; Synonyms=D1Pas1-rs2, Ddx3, Dead3, Erh;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSEX.PE244.
CC       Mus musculus chromosome X NCBIM37  sequence 1..166650296 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:DDX3X_MOUSE
CC   -!- FUNCTION: Putative ATP-dependent RNA helicase. It may play a role
CC       in translational activation of mRNA in the oocyte and early
CC       embryo.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate.
CC   -!- SUBUNIT: Identified in a mRNP complex, at least composed of DHX9,
CC       DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1,
CC       STAU2, SYNCRIP and YBX1. Interacts with XPO1 and TDRD3 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus speckle (By similarity). Cytoplasm
CC       (By similarity). Note=Located predominantly in nuclear speckles
CC       and, at low levels, throughout the cytoplasm. Located to the outer
CC       side of nuclear pore complexes (NPC). Shuttles between the nucleus
CC       and the cytoplasm in a XPO1-dependent manner (By similarity).
CC   -!- TISSUE SPECIFICITY: Developmentally regulated.
CC   -!- DEVELOPMENTAL STAGE: Expressed in oocytes. Ubiquitously found in 9
CC       days post-conception embryo, at later stages it is restricted to
CC       brain and kidney.
CC   -!- PTM: Phosphorylated by TBK1 (By similarity).
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 helicase ATP-binding domain.
CC   -!- SIMILARITY: Contains 1 helicase C-terminal domain.
CC   -!- GENE_FAMILY: HOG000268804 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000000787;ENSMUST00000000804;ENSMUSP00000000804.
DR   EMBL; AK140990; - ;
DR   EMBL; AK163250; - ;
DR   EMBL; AL833805; - ;
DR   EMBL; BC150862; - ;
DR   EMBL; BC172016; - ;
DR   EMBL; L25126; - ;
DR   EMBL; Z38117; - ;
DR   UniProtKB/Swiss-Prot; Q62167; O09060; O09143; -.
DR   EMBL; Z38117; CAA86261.1; -; mRNA.
DR   EMBL; L25126; AAA53630.1; -; mRNA.
DR   IPI; IPI00230035; -.
DR   PIR; I84741; I84741.
DR   RefSeq; NP_034158.1; NM_010028.3.
DR   UniGene; Mm.289662; -.
DR   UniGene; Mm.474961; -.
DR   ProteinModelPortal; Q62167; -.
DR   SMR; Q62167; 168-580.
DR   IntAct; Q62167; 1.
DR   MINT; MINT-1870173; -.
DR   STRING; Q62167; -.
DR   PhosphoSite; Q62167; -.
DR   REPRODUCTION-2DPAGE; Q62167; -.
DR   PRIDE; Q62167; -.
DR   Ensembl; ENSMUST00000000804; ENSMUSP00000000804; ENSMUSG00000000787.
DR   GeneID; 13205; -.
DR   KEGG; mmu:13205; -.
DR   CTD; 1654; -.
DR   MGI; MGI:103064; Ddx3x.
DR   eggNOG; roNOG09378; -.
DR   GeneTree; ENSGT00390000005849; -.
DR   InParanoid; Q62167; -.
DR   OMA; KYERGGN; -.
DR   OrthoDB; EOG47D9FV; -.
DR   PhylomeDB; Q62167; -.
DR   NextBio; 283364; -.
DR   ArrayExpress; Q62167; -.
DR   Bgee; Q62167; -.
DR   CleanEx; MM_ERH; -.
DR   Genevestigator; Q62167; -.
DR   GermOnline; ENSMUSG00000000787; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008026; F:ATP-dependent helicase activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   InterPro; IPR014001; DEAD-like_helicase.
DR   InterPro; IPR011545; DNA/RNA_helicase_DEAD/DEAH_N.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
DR   HOGENOMDNA; MOUSEX.PE244; -.
KW   ENSMUSG000000007875old_1320000031; ENSMUSP000000008041old_1320000031;
KW   B7ZWF1_MOUSE; B9EKE9_MOUSE; Q3TQX5_MOUSE; AK140990; AK163250; AL833805;
KW   BC172016; L25126; Z38117;
KW   Acetylation; ATP-binding; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; DNA-binding; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome;
KW   RNA-binding.
SQ   SEQUENCE   662 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSHVAVENAL GLDQQFAGLD LNSSDNQSGG STASKGRYIP PHLRNREATK GFYDKDSSGW
     SSSKDKDAYS SFGSRGDSRG KSSFFGDRGS GSRGRFDDRG RGDYDGIGGR GDRSGFGKFE
     RGGNSRWCDK SDEDDWSKPL PPSERLEQEL FSGGNTGINF EKYDDIPVEA TGNNCPPHIE
     SFSDVEMGEI IMGNIELTRY TRPTPVQKHA IPIIKEKRDL MACAQTGSGK TAAFLLPILS
     QIYADGPGEA LRAMKENGRY GRRKQYPISL VLAPTRELAV QIYEEARKFS YRSRVRPCVV
     YGGAEIGQQI RDLERGCHLL VATPGRLVDM MERGKIGLDF CKYLVLDEAD RMLDMGFEPQ
     IRRIVEQDTM PPKGVRHTMM FSATFPKEIQ MLARDFLDEY IFLAVGRVGS TSENITQKVV
     WVEEIDKRSF LLDLLNATGK DSLTLVFVET KKGADSLEDF LYHEGYACTS IHGDRSQRDR
     EEALHQFRSG KSPILVATAV AARGLDISNV KHVINFDLPS DIEEYVHRIG RTGRVGNLGL
     ATSFFNERNI NITKDLLDLL VEAKQEVPSW LENMAFEHHY KGSSRGRSKS SRFSGGFGAR
     DYRQSSGASS SSFSSSRASS SRSGGGGHGG SRGFGGGGYG GFYNSDGYGG NYNSQGVDWW
     GN
//

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