(data stored in ACNUC19356 zone)

HOGENOM: MOUSEX_PE37

ID   MOUSEX_PE37                          STANDARD;      PRT;   429 AA.
AC   MOUSEX_PE37; Q99JB6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Forkhead box protein P3;AltName: Full=Scurfin;
DE   (MOUSEX.PE37).
GN   Name=Foxp3;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSEX.PE37.
CC       Mus musculus chromosome X NCBIM37  sequence 1..166650296 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:FOXP3_MOUSE
CC   -!- FUNCTION: Probable transcription factor. Plays a critical role in
CC       the control of immune response.
CC   -!- SUBUNIT: Interacts with IKZF3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- TISSUE SPECIFICITY: High level of expression in thymus and spleen.
CC   -!- DISEASE: Note=Defects in Foxp3 are the cause of the scurfy
CC       phenotype (sf). It results in a lethal disorder of
CC       immunoregulation, characterized by infections, diarrhea, anemia,
CC       thrombocytopenia, hypogonadism, gastrointestinal bleeding,
CC       lymphadenopathy and leukocytosis.
CC   -!- SIMILARITY: Contains 1 C2H2-type zinc finger.
CC   -!- SIMILARITY: Contains 1 fork-head DNA-binding domain.
CC   -!- GENE_FAMILY: HOG000082490 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000039521;ENSMUST00000115740;ENSMUSP00000111405.
DR   EMBL; AF277991; - ;
DR   EMBL; AF277992; - ;
DR   EMBL; AF277994; - ;
DR   EMBL; AK157447; - ;
DR   EMBL; AL672231; - ;
DR   EMBL; AY357712; - ;
DR   EMBL; AY357713; - ;
DR   EMBL; BC132333; - ;
DR   EMBL; BC132335; - ;
DR   EMBL; CH466638; - ;
DR   EMBL; DQ387959; - ;
DR   UniProtKB/Swiss-Prot; Q99JB6; -.
DR   EMBL; AF277994; AAG53608.1; -; Genomic_DNA.
DR   EMBL; AF277991; AAG53605.1; -; mRNA.
DR   EMBL; AF277992; AAG53606.1; -; mRNA.
DR   IPI; IPI00115123; -.
DR   RefSeq; NP_001186276.1; NM_001199347.1.
DR   RefSeq; NP_001186277.1; NM_001199348.1.
DR   RefSeq; NP_473380.1; NM_054039.2.
DR   UniGene; Mm.182291; -.
DR   ProteinModelPortal; Q99JB6; -.
DR   SMR; Q99JB6; 336-417.
DR   STRING; Q99JB6; -.
DR   PRIDE; Q99JB6; -.
DR   Ensembl; ENSMUST00000045566; ENSMUSP00000041953; ENSMUSG00000039521.
DR   Ensembl; ENSMUST00000115738; ENSMUSP00000111403; ENSMUSG00000039521.
DR   Ensembl; ENSMUST00000115739; ENSMUSP00000111404; ENSMUSG00000039521.
DR   Ensembl; ENSMUST00000115740; ENSMUSP00000111405; ENSMUSG00000039521.
DR   GeneID; 20371; -.
DR   KEGG; mmu:20371; -.
DR   CTD; 50943; -.
DR   MGI; MGI:1891436; Foxp3.
DR   GeneTree; ENSGT00560000076806; -.
DR   InParanoid; Q99JB6; -.
DR   OMA; PSRCSNP; -.
DR   OrthoDB; EOG4F7NK4; -.
DR   PhylomeDB; Q99JB6; -.
DR   NextBio; 298278; -.
DR   ArrayExpress; Q99JB6; -.
DR   Bgee; Q99JB6; -.
DR   CleanEx; MM_FOXP3; -.
DR   Genevestigator; Q99JB6; -.
DR   GermOnline; ENSMUSG00000039521; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051525; F:NFAT protein binding; ISS:UniProtKB.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0003705; F:sequence-specific enhancer binding RNA polymerase II transcription factor activity; IDA:MGI.
DR   GO; GO:0003714; F:transcription corepressor activity; IDA:MGI.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0001782; P:B cell homeostasis; IMP:MGI.
DR   GO; GO:0002361; P:CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IMP:MGI.
DR   GO; GO:0001816; P:cytokine production; IDA:MGI.
DR   GO; GO:0002262; P:myeloid cell homeostasis; IMP:MGI.
DR   GO; GO:0002677; P:negative regulation of chronic inflammatory response; IDA:MGI.
DR   GO; GO:0032792; P:negative regulation of CREB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0050710; P:negative regulation of cytokine secretion; ISS:UniProtKB.
DR   GO; GO:0035067; P:negative regulation of histone acetylation; IDA:MGI.
DR   GO; GO:0045077; P:negative regulation of interferon-gamma biosynthetic process; IDA:MGI.
DR   GO; GO:0032689; P:negative regulation of interferon-gamma production; ISS:UniProtKB.
DR   GO; GO:0032693; P:negative regulation of interleukin-10 production; ISS:UniProtKB.
DR   GO; GO:0045085; P:negative regulation of interleukin-2 biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0032703; P:negative regulation of interleukin-2 production; ISS:UniProtKB.
DR   GO; GO:0032713; P:negative regulation of interleukin-4 production; ISS:UniProtKB.
DR   GO; GO:0032714; P:negative regulation of interleukin-5 production; IDA:MGI.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; IMP:MGI.
DR   GO; GO:0048294; P:negative regulation of isotype switching to IgE isotypes; IMP:MGI.
DR   GO; GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0002725; P:negative regulation of T cell cytokine production; ISS:UniProtKB.
DR   GO; GO:0042130; P:negative regulation of T cell proliferation; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0032720; P:negative regulation of tumor necrosis factor production; IMP:MGI.
DR   GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation;DR   GO; GO:0035066; P:positive regulation of histone acetylation; IDA:MGI.
DR   GO; GO:0035066; P:positive regulation of histone acetylation; IDA:MGI.
DR   GO; GO:0033092; P:positive regulation of immature T cell proliferation in thymus; IMP:MGI.
DR   GO; GO:0002851; P:positive regulation of peripheral T cell tolerance induction; IMP:MGI.
DR   GO; GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.
DR   GO; GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
DR   GO; GO:0032914; P:positive regulation of transforming growth factor-beta1 production; IDA:MGI.
DR   GO; GO:0048302; P:regulation of isotype switching to IgG isotypes; IMP:MGI.
DR   GO; GO:0002456; P:T cell mediated immunity; IMP:MGI.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IMP:MGI.
DR   GO; GO:0002513; P:tolerance induction to self antigen; IMP:MGI.
DR   InterPro; IPR001766; TF_fork_head.
DR   InterPro; IPR018122; TF_fork_head_CS.
DR   InterPro; IPR011991; WHTH_trsnscrt_rep_DNA-bd.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   Gene3D; G3DSA:1.10.10.10; Wing_hlx_DNA_bd; 1.
DR   Pfam; PF00250; Fork_head; 1.
DR   PRINTS; PR00053; FORKHEAD.
DR   SMART; SM00339; FH; 1.
DR   SMART; SM00355; ZnF_C2H2; 1.
DR   PROSITE; PS00657; FORK_HEAD_1; FALSE_NEG.
DR   PROSITE; PS00658; FORK_HEAD_2; 1.
DR   PROSITE; PS50039; FORK_HEAD_3; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; FALSE_NEG.
DR   HOGENOMDNA; MOUSEX.PE37; -.
KW   ENSMUSG000000395215old_1320000031; ENSMUSP000001114051old_1320000031;
KW   Q53Z59_MOUSE; AF277991; AF277992; AF277994; AK157447; AL672231; AY357712;
KW   BC132333; BC132335; CH466638; DQ387959;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
SQ   SEQUENCE   429 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPNPRPAKPM APSLALGPSP GVLPSWKTAP KGSELLGTRG SGGPFQGRDL RSGAHTSSSL
     NPLPPSQLQL PTVPLVMVAP SGARLGPSPH LQALLQDRPH FMHQLSTVDA HAQTPVLQVR
     PLDNPAMISL PPPSAATGVF SLKARPGLPP GINVASLEWV SREPALLCTF PRSGTPRKDS
     NLLAAPQGSY PLLANGVCKW PGCEKVFEEP EEFLKHCQAD HLLDEKGKAQ CLLQREVVQS
     LEQQLELEKE KLGAMQAHLA GKMALAKAPS VASMDKSSCC IVATSTQGSV LPAWSAPREA
     PDGGLFAVRR HLWGSHGNSS FPEFFHNMDY FKYHNMRPPF TYATLIRWAI LEAPERQRTL
     NEIYHWFTRM FAYFRNHPAT WKNAIRHNLS LHKCFVRVES EKGAVWTVDE FEFRKKRSQR
     PNKCSNPCP
//

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