(data stored in ACNUC26462 zone)

HOGENOM: MOUSEX_PE870

ID   MOUSEX_PE870                         STANDARD;      PRT;   343 AA.
AC   MOUSEX_PE870; Q9QYK9; Q80W07;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Calcium/calmodulin-dependent protein kinase type 1B;
DE   EC=2.7.11 17;AltName: Full=CaM kinase I beta; Short=CaM kinase IB;
DE   Short=CaM-KI beta; Short=CaMKI-beta;AltName: Full=Pregnancy up-regulated
DE   non-ubiquitously-expressed CaM kinase homolog; (MOUSEX.PE870).
GN   Name=Pnck;
OS   MUS MUSCULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MOUSEX.PE870.
CC       Mus musculus chromosome X NCBIM37  sequence 1..166650296 annotated by
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:KCC1B_MOUSE
CC   -!- FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to
CC       a proposed calcium-triggered signaling cascade. In vitro
CC       phosphorylates CREB1 and SYN1/synapsin I. Phosphorylates and
CC       activates CAMK1 (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- ENZYME REGULATION: Activated by Ca(2+)/calmodulin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC   -!- TISSUE SPECIFICITY: Expressed at highest levels in adult brain,
CC       and expressed in embryo. In the adult brain detected at high
CC       levels in the anterior olfactory nuclei, piriform cortex, septal
CC       nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal
CC       cells, dentate granule cells, amygdala, hypothalamic nuclei,
CC       parabrachial nucleus, and nucleus of the solitary tract. Expressed
CC       at lower levels in adult ovary and heart and at very low levels in
CC       testis, lung and muscle.
CC   -!- DEVELOPMENTAL STAGE: During embryogenesis detected at E10 and
CC       expression gradually increases thereafter. Expressed mainly in the
CC       nervous system, including brain, spinal cord, trigeminal ganglion,
CC       and retina. Within the CNS detected in the mantle zone, but not in
CC       the ventricular zone. Detected at postnatal day 23 with highest
CC       levels in mesencephalon. Also expressed in developing bone and
CC       gut.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family. CaMK subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH51996.1; Type=Erroneous initiation;
CC   -!- GENE_FAMILY: HOG000233016 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Mus_musculus;ENSMUSG00000002012;ENSMUST00000114473;ENSMUSP00000110117.
DR   EMBL; AB023027; - ;
DR   EMBL; AF181984; - ;
DR   EMBL; AK134665; - ;
DR   EMBL; AK158755; - ;
DR   EMBL; AL805924; - ;
DR   EMBL; BC051996; - ;
DR   EMBL; BC055891; - ;
DR   EMBL; CH466650; - ;
DR   UniProtKB/Swiss-Prot; Q9QYK9; Q80W07; -.
DR   EMBL; AB023027; BAA87926.1; -; mRNA.
DR   EMBL; AF181984; AAF29157.1; -; mRNA.
DR   EMBL; BC051996; AAH51996.1; ALT_INIT; mRNA.
DR   EMBL; BC055891; AAH55891.1; -; mRNA.
DR   IPI; IPI00136288; -.
DR   RefSeq; NP_001186280.1; NM_001199351.1.
DR   RefSeq; NP_001186281.1; NM_001199352.1.
DR   RefSeq; NP_036170.1; NM_012040.3.
DR   UniGene; Mm.89564; -.
DR   ProteinModelPortal; Q9QYK9; -.
DR   SMR; Q9QYK9; 8-294.
DR   STRING; Q9QYK9; -.
DR   PhosphoSite; Q9QYK9; -.
DR   PRIDE; Q9QYK9; -.
DR   Ensembl; ENSMUST00000002087; ENSMUSP00000002087; ENSMUSG00000002012.
DR   Ensembl; ENSMUST00000114472; ENSMUSP00000110116; ENSMUSG00000002012.
DR   Ensembl; ENSMUST00000114473; ENSMUSP00000110117; ENSMUSG00000002012.
DR   GeneID; 93843; -.
DR   KEGG; mmu:93843; -.
DR   CTD; 139728; -.
DR   MGI; MGI:1347357; Pnck.
DR   GeneTree; ENSGT00600000084207; -.
DR   InParanoid; Q9QYK9; -.
DR   OMA; IYESPTH; -.
DR   OrthoDB; EOG4T4CVW; -.
DR   PhylomeDB; Q9QYK9; -.
DR   NextBio; 351709; -.
DR   ArrayExpress; Q9QYK9; -.
DR   Bgee; Q9QYK9; -.
DR   Genevestigator; Q9QYK9; -.
DR   GermOnline; ENSMUSG00000002012; Mus musculus.
DR   GO; GO:0005954; C:calcium- and calmodulin-dependent protein kinase complex; TAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0004683; F:calmodulin-dependent protein kinase activity; IEA:EC.
DR   InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   PANTHER; PTHR24347; PTHR24347; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; MOUSEX.PE870; -.
KW   ENSMUSG000000020125old_1320000031; ENSMUSP000001101171old_1320000031;
KW   A2ALM3_MOUSE; Q3TYC1_MOUSE; Q3UYI0_MOUSE; AB023027; AF181984; AK134665;
KW   AL805924; BC051996; BC055891; CH466650;
KW   ATP-binding; Calcium; Calmodulin-binding; Complete proteome;
KW   Cytoplasm; Kinase; Nucleotide-binding; Nucleus; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   343 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLLLKKQTED ISSVYEIREK LGSGAFSEVM LAQERGSAHL VALKCIPKKA LRGKEALVEN
     EIAVLRRISH PNIVALEDVH ESPSHLYLAM ELVTGGELFD RIMERGSYTE KDASHLVGQV
     LGAVSYLHSL GIVHRDLKPE NLLYATPFED SKIMVSDFGL SKIQAGNMLG TACGTPGYVA
     PELLEQKPYG KAVDVWALGV ISYILLCGYP PFYDESDPEL FSQILRASYE FDSPFWDDIS
     ESAKDFIRHL LERDPQKRFT CQQALQHLWI SGDAAFDRDI LGSVSEQIQK NFARTHWKRA
     FNATSFLRHI RKLGQSPEGE EASRQCMTRH SHPGLGTSQS PKW
//

If you have problems or comments...

PBIL Back to PBIL home page