(data stored in SCRATCH3701 zone)

HOGENOM6: MYCA1_1_PE6

ID   MYCA1_1_PE6                          STANDARD;      PRT;   839 AA.
AC   MYCA1_1_PE6; A0Q8S1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase, A subunit; EC=5.99.1 3; (MYCA1_1.PE6).
GN   Name=gyrA; OrderedLocusNames=MAV_0006;
OS   MYCOBACTERIUM AVIUM 104.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium avium
OC   complex (MAC).
OX   NCBI_TaxID=243243;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCA1_1.PE6.
CC       Mycobacterium avium 104, complete genome.
CC       Ensembl
CC   -!- ANNOTATIONS ORIGIN:A0Q8S1_MYCA1
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A0Q8S1; -.
DR   EMBL; CP000479; ABK64957.1; -; Genomic_DNA.
DR   RefSeq; YP_879309.1; NC_008595.1.
DR   ProteinModelPortal; A0Q8S1; -.
DR   STRING; A0Q8S1; -.
DR   EnsemblBacteria; EBMYCT00000012850; EBMYCP00000012736; EBMYCG00000012848.
DR   GeneID; 4527270; -.
DR   GenomeReviews; CP000479_GR; MAV_0006.
DR   KEGG; mav:MAV_0006; -.
DR   TIGR; MAV_0006; -.
DR   eggNOG; COG0188; -.
DR   GeneTree; EBGT00050000016653; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; MYCA1_1.PE6; -.
DR   PRODOM; MYCA1_1_PE6.
DR   SWISS-2DPAGE; MYCA1_1_PE6.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   839 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPGG DAADRVEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG
     GIAVGMATNI PPHNLGELAE AVFWALDNYE ADEEATLAAV MERVKGPDFP TSGLIVGTQG
     IADAYKTGRG SIRMRGVVEV EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRDGKLAGI
     SNIEDQSSDR VGLRIVIELK RDAVAKVVLN NLYKHTQLQT SFGANMLAIV DGVPRTLRLD
     QLIRHYVDHQ LDVIVRRTTY RLRKANERAH ILRGLVKALD ALDEVIALIR ASETVDIARQ
     GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIIDDLAKIE AEIADLEDIL AKPERQRGIV
     RDELAEIVEK HGDARRTRIV AADGDVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR
     GGKGVQGAGL KQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL
     LAFQPEERIA QVIQIRSYED APYLVLATRN GLVKKTKLTD FDSNRSGGIV AINLRDNDEL
     VGAVLCSAED DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD YLLSLNVVRE
     GTYLLVATSG GYAKRTAIEE YPVQGRGGKG VLTVMYDRRR GRLVGALIVD EDSELYAITS
     GGGVIRTAAG QVRKAGRQTK GVRLMNLGEG DTLLAIARNA EEAADEAVEE SDGAAGSDG
//

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