(data stored in SCRATCH3701 zone)

HOGENOM6: MYCMM_2_PE6

ID   MYCMM_2_PE6                          STANDARD;      PRT;   839 AA.
AC   MYCMM_2_PE6; B2HI51;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase (MYCMM_2.PE6) (Subunit A) GyrA; .
GN   Name=gyrA; OrderedLocusNames=MMAR_0006;
OS   MYCOBACTERIUM MARINUM M.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCMM_2.PE6.
CC       Mycobacterium marinum M, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:B2HI51_MYCMM
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B2HI51; -.
DR   EMBL; CP000854; ACC38477.1; -; Genomic_DNA.
DR   RefSeq; YP_001848332.1; NC_010612.1.
DR   STRING; B2HI51; -.
DR   EnsemblBacteria; EBMYCT00000035999; EBMYCP00000034439; EBMYCG00000035994.
DR   GeneID; 6224530; -.
DR   GenomeReviews; CP000854_GR; MMAR_0006.
DR   KEGG; mmi:MMAR_0006; -.
DR   GeneTree; EBGT00050000016653; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; MYCMM_2.PE6; -.
DR   PRODOM; MYCMM_2_PE6.
DR   SWISS-2DPAGE; MYCMM_2_PE6.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   839 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPGG EASDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG
     GIAVGMATNI PPHNLRELAE AVFWCLENHD ADEEATLAAV TERVKGPDFP TSGLIVGTQG
     ISDAYKTGRG SIRMRGVVEI EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRDGKLAGI
     SNIEDQSSDR VGLRIVVEIK RDAVAKVVLN NLYKHTQLQT SFGANMLSIV DGVPRTLRLD
     QMIRYYVEHQ LDVIIRRTTY RLRKANERAH ILRGLVKALD ALDEVIALIR ASQTVDIARV
     GLIELLDIDE IQAQAILDMQ LRRLAALERQ RIVDDLAKIE AEIADLEDIL AKPERQRAIV
     RDELAEIVDK HGDDRRTRII AADGEVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR
     GGKGVQGAGL KQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEALR TARGQHVANL
     LAFQPEERIA QVIQIKSYED APYLVLATQN GLVKKSKLTD FDSNRSGGIV AINLRGEDEL
     VGAVLCSSEE DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD RLLSLNVVRE
     GTYLLVATAG GYAKRTGIEE YPVQGRGGKG VLTIMYDRRR GRLVGALIVD DDSELYAITS
     GGGVIRTAAR QVRKAGRQTK GVRLMNLGEG DTLLAIARNA EENADEAVAE ATDTDESSN
//

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