(data stored in SCRATCH3701 zone)

HOGENOM6: MYCOB1_3_PE7

ID   MYCOB1_3_PE7                         STANDARD;      PRT;   1261 AA.
AC   MYCOB1_3_PE7; E6TGR3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (MYCOB1_3.PE7).
GN   OrderedLocusNames=Mspyr1_00070;
OS   MYCOBACTERIUM SP. SPYR1.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=278137;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCOB1_3.PE7.
CC       Mycobacterium sp. Spyr1 chromosome, complete genome.
CC       complete sequence.
CC   -!- ANNOTATIONS ORIGIN:E6TGR3_MYCSR
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E6TGR3; -.
DR   EMBL; CP002385; ADT96747.1; -; Genomic_DNA.
DR   RefSeq; YP_004074582.1; NC_014814.1.
DR   ProteinModelPortal; E6TGR3; -.
DR   SMR; E6TGR3; 38-130, 132-238, 495-551.
DR   GeneID; 10044405; -.
DR   GenomeReviews; CP002385_GR; Mspyr1_00070.
DR   KEGG; msp:Mspyr1_00070; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR003586; Hedgehog_hint_C.
DR   InterPro; IPR003587; Hedgehog_hint_N.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_splice_site.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 2.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 2.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   TIGRFAMs; TIGR01443; Intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; Intein_Nterm; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
DR   HOGENOMDNA; MYCOB1_3.PE7; -.
DR   PRODOM; MYCOB1_3_PE7.
DR   SWISS-2DPAGE; MYCOB1_3_PE7.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   1261 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPGD EAGDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     FDSGFRPDRG HAKSARSVAE TMGNYHPHGD SSIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY CVTGDAMVRL PFGQSVRIAD IVKGARPNSD NDIDVKVLDR HGDPVVANAL
     FHSGDHETFA VRTAEGYEVT GTSNHPLLCL VDVGGVPTLL WKLIGEIRPG DHVVLQRTPP
     VEFGPGDWRE VMEALLLGAF ISDGFVSESR AGFNNLDRDY FNMVLAAYDA IVGGPRYVYE
     RRIASGSKLL ELDVHNLRAL DSSRLAELKS QRSAAKTVPN WLWNSTAAAK KAFLQALFEG
     DGSCSALPHN TIQLSYSTRS GQLAKDVQNM LLEFGVISRR YLHATGEHKV VITNRAHAED
     FCLRIGFGGA KQEKLQELLA ALPARAAGLD GDHVPGLATF IRSRSGGRWI DKEWLRKHNI
     DRLTRWRRDR EEILSHISDN DVRSIATELT DGRFYYARVA SVSDAGVQPV YSLRVDTDDH
     SFITNGFVSH NTEARLTPLA MEMLREIDEE TVDFVPNYDG RVQEPTVLPS RFPNLLANGS
     GGIAVGMATN MPPHNLRELA EAVYWCLDNH EADEEATLDA VCERVKGPDF PTYGLIVGSQ
     GIDDTYKTGR GSIRMRGVVE IEEDARGRTS LVITELPYQV NHDNFITSIA EQVRDGKLTG
     ISNIEDQSSD RVGLRIVVEI KRDAVAKVVL NNLYKHTQLQ TSFGANMLSI VDGVPRTLRL
     DQLIRHYVNH QLDVIVRRTR YRLRKANERA HILRGLVKAL DALDEVIALI RASQTVEIAR
     SGLIELLDID EIQAQAILDM QLRRLAALER QRIVDDLAKI EAEIADLEDI LAKPERQRAI
     VHDELKEIVD KYGDDRRTRI IPADGDVADE DLIAREEVVV TITETGYAKR TKSDLYRSQK
     RGGKGVQGAG LKQDDIVNHF FVCSTHDWIL FFTTQGRVYR AKAYDLPEAS RTARGQHVAN
     LLAFQPEERI AQVIQLKTYE DAPYLVLATR NGLVKKSRLV DFDSNRSGGI VAVNLRDGDE
     LVGAVLCSAD DDLLLVSAKG QSIRFSATDE ALRPMGRATS GVQGMRFNEE DQLLSLNVVR
     EGTYLLVATS GGYAKRTAIE EYSAQGRGGK GILTIQYDRR RGTLVGALIV DDDTELYAIT
     SGGGVIRTAA RQVRKAGRQT KGVRLMNLGE GDTLIAIARN AEAGDSTDEV ETDPDATDEE
     S
//

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