(data stored in ACNUC30630 zone)

HOGENOM: MYCS2_1_PE3109

ID   MYCS2_1_PE3109                       STANDARD;      PRT;   524 AA.
AC   MYCS2_1_PE3109; A0QX93;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (MYCS2_1.PE3109).
GN   Name=trpE; OrderedLocusNames=MSMEG_3217;
OS   MYCOBACTERIUM SMEGMATIS STR. MC2 155.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=246196;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCS2_1.PE3109.
CC       Mycobacterium smegmatis str. MC2 155, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:TRPE_MYCS2
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity (By similarity).
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A0QX93; -.
DR   EMBL; CP000480; ABK74885.1; -; Genomic_DNA.
DR   RefSeq; YP_887531.1; NC_008596.1.
DR   ProteinModelPortal; A0QX93; -.
DR   STRING; A0QX93; -.
DR   EnsemblBacteria; EBMYCT00000043642; EBMYCP00000041979; EBMYCG00000043637.
DR   GeneID; 4531670; -.
DR   GenomeReviews; CP000480_GR; MSMEG_3217.
DR   KEGG; msm:MSMEG_3217; -.
DR   NMPDR; fig|246196.1.peg.3227; -.
DR   TIGR; MSMEG_3217; -.
DR   eggNOG; COG0147; -.
DR   GeneTree; EBGT00050000015088; -.
DR   OMA; MSCLMES; -.
DR   PhylomeDB; A0QX93; -.
DR   ProtClustDB; PRK13571; -.
DR   BioCyc; MSME246196:MSMEG_3217-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; MYCS2_1.PE3109; -.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Isopeptide bond; Lyase; Reference proteome;
KW   Tryptophan biosynthesis; Ubl conjugation.
SQ   SEQUENCE   524 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQTTANHSSR STQTGTRAHG AALAETTSRE DFRALATEHR VVPVIRKVLA DSETPLSAYR
     KLAANRPGTF LLESAENGRS WSRWSFIGAG APSALTVRDN AAAWLGTAPE GAPSGGDPLD
     ALRATLDLLK TEAMAGLPPL SSGLVGFFAY DMVRRLERLP ELAVDDLGLP DMLLLLATDI
     AAVDHHEGTI TLIANAVNWN GTDERVDWAY DDAVARLDVM TKALGQPLTS AVATFSRPAP
     DHRAQRTMEE YTEIVDKLVG DIEAGEAFQV VPSQRFEMDT AADPLDVYRI LRVTNPSPYM
     YLLNIPDADG GLDFSIVGSS PEALVTVKDG RATTHPIAGT RWRGATEEED VLLEKELLAD
     EKERAEHLML VDLGRNDLGR VCRPGTVRVD DYSHIERYSH VMHLVSTVTG ELAEDKTALD
     AVTACFPAGT LSGAPKVRAM ELIEEVEKTR RGLYGGVVGY LDFAGNADFA IAIRTALMRN
     GTAYVQAGGG VVADSNGPYE YTEAANKARA VLNAIAAAAT LAEP
//

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