(data stored in SCRATCH3701 zone)

HOGENOM6: MYCS2_1_PE6

ID   MYCS2_1_PE6                          STANDARD;      PRT;   842 AA.
AC   MYCS2_1_PE6; P48354; A0QNE1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3; (MYCS2_1.PE6).
GN   Name=gyrA; OrderedLocusNames=MSMEG_0006;
OS   MYCOBACTERIUM SMEGMATIS STR. MC2 155.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=246196;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCS2_1.PE6.
CC       Mycobacterium smegmatis str. MC2 155, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_MYCS2
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P48354; A0QNE1; -.
DR   EMBL; X94224; CAA63918.1; -; Genomic_DNA.
DR   EMBL; CP000480; ABK69994.1; -; Genomic_DNA.
DR   RefSeq; YP_884429.1; NC_008596.1.
DR   ProteinModelPortal; P48354; -.
DR   STRING; P48354; -.
DR   EnsemblBacteria; EBMYCT00000044470; EBMYCP00000042807; EBMYCG00000044465.
DR   GeneID; 4535988; -.
DR   GenomeReviews; CP000480_GR; MSMEG_0006.
DR   KEGG; msm:MSMEG_0006; -.
DR   NMPDR; fig|246196.1.peg.6; -.
DR   TIGR; MSMEG_0006; -.
DR   eggNOG; COG0188; -.
DR   GeneTree; EBGT00050000016653; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; MSME246196:MSMEG_0006-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; MYCS2_1.PE6; -.
DR   PRODOM; MYCS2_1_PE6.
DR   SWISS-2DPAGE; MYCS2_1_PE6.
KW   Antibiotic resistance; ATP-binding; Complete proteome; Cytoplasm;
KW   DNA-binding; Isomerase; Nucleotide-binding; Reference proteome;
KW   Topoisomerase.
SQ   SEQUENCE   842 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPEG EAHDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     YDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY TEARLTPLAM EMLREIDEET VDFIPNYDGR VQEPTVLPSR FPNLLANGSG
     GIAVGMATNI PPHNLGELAE AVYWCLENYE ADEEATCEAV MERVKGPDFP TSGLIVGTQG
     IEDTYKTGRG SIKMRGVVEI EEDSRGRTSI VITELPYQVN HDNFITSIAE QVRDGKLAGI
     SNIEDQSSDR VGLRIVVELK RDAVAKVVLN NLYKHTQLQT SFGANMLSIV DGVPRTLRLD
     QLIRLYVDHQ LDVIVRRTRY RLRKANERAH ILRGLVKALD ALDEVIALIR ASQTVDIARA
     GLIELLDIDD IQAQAILDMQ LRRLAALERQ KIVDDLAKIE AEIADLEDIL AKPERQRGIV
     RDELKEIVDK HGDARRTRIV PADGEVSDED LIAREDVVVT ITETGYAKRT KTDLYRSQKR
     GGKGVQGAGL KQDDMVNHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL
     LAFQPEERIA QVIQIKSYED APYLVLATRN GLVKKSKLSD FDSNRSGGIV AINLREGDEL
     VGAVLCSAED DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNEDD RLLSLNVVRP
     DTYLLVATSG GYAKRTSIDE YSVQGRGGKG ILTIQYDRKR GSLVGALIVD DDTELYAITS
     TGGVIRTAAR QVRKAGRQTK GVRLMNLAEG DTLIAIARNA DEDEAAESIS ESDADTAESP
     EA
//

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