(data stored in ACNUC7421 zone)

HOGENOM: MYCTK_1_PE1005

ID   MYCTK_1_PE1005                       STANDARD;      PRT;   198 AA.
AC   MYCTK_1_PE1005; C6DW62;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-isopropylmalate dehydratase small subunit; EC=4.2.1
DE   33;AltName: Full=Alpha-IPM isomerase;AltName: Full=Isopropylmalate
DE   isomerase; (MYCTK_1.PE1005).
GN   Name=leuD; OrderedLocusNames=TBMG_00982;
OS   MYCOBACTERIUM TUBERCULOSIS KZN 1435.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=478434;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCTK_1.PE1005.
CC       Mycobacterium tuberculosis KZN 1435, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:C6DW62_MYCTK
CC   -!- FUNCTION: Catalyzes the isomerization between 2-isopropylmalate
CC       and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (2R,3S)-3-isopropylmalate = (2S)-2-
CC       isopropylmaleate + H(2)O.
CC   -!- CATALYTIC ACTIVITY: (2S)-2-isopropylmaleate + H(2)O = (2S)-2-
CC       isopropylmalate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-leucine biosynthesis; L-
CC       leucine from 3-methyl-2-oxobutanoate: step 2/4.
CC   -!- SUBUNIT: Heterodimer of leuC and leuD (By similarity).
CC   -!- SIMILARITY: Belongs to the leuD family. LeuD type 1 subfamily.
CC   -!- GENE_FAMILY: HOG000222939 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6DW62; -.
DR   EMBL; CP001658; ACT24026.1; -; Genomic_DNA.
DR   RefSeq; YP_003030921.1; NC_012943.1.
DR   ProteinModelPortal; C6DW62; -.
DR   STRING; C6DW62; -.
DR   EnsemblBacteria; EBMYCT00000094016; EBMYCP00000087914; EBMYCG00000093002.
DR   GeneID; 8162275; -.
DR   GenomeReviews; CP001658_GR; TBMG_00982.
DR   KEGG; mtb:TBMG_00982; -.
DR   GeneTree; EBGT00050000015493; -.
DR   ProtClustDB; PRK01641; -.
DR   GO; GO:0009316; C:3-isopropylmalate dehydratase complex; IEA:InterPro.
DR   GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:HAMAP.
DR   GO; GO:0009098; P:leucine biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01031; LeuD_type1; 1; -.
DR   InterPro; IPR004431; 3-IsopropMal_deHydase_ssu.
DR   InterPro; IPR015937; Acoase/IPM_deHydtase.
DR   InterPro; IPR015928; Aconitase/3IPM_dehydase_swvl.
DR   InterPro; IPR000573; AconitaseA/IPMdHydase_ssu_swvl.
DR   InterPro; IPR015936; Homoacnase/3IPM_deHydtase_su.
DR   Gene3D; G3DSA:3.20.19.10; Aconitase/3IPM_dehydase_swvl; 1.
DR   PANTHER; PTHR11670; Aconitase-like_core; 1.
DR   PANTHER; PTHR11670:SF6; Homoacnase/3IPM_dehydase_s/lsu; 1.
DR   Pfam; PF00694; Aconitase_C; 1.
DR   SUPFAM; SSF52016; Aconitase/3IPM_dehydase_swvl; 1.
DR   TIGRFAMs; TIGR00171; LeuD; 1.
DR   HOGENOMDNA; MYCTK_1.PE1005; -.
KW   isopropylmalate isomerase small subunit;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Complete proteome; Leucine biosynthesis; Lyase.
SQ   SEQUENCE   198 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEAFHTHSGI GVPLRRSNVD TDQIIPAVFL KRVTRTGFED GLFAGWRSDP AFVLNLSPFD
     RGSVLVAGPD FGTGSSREHA VWALMDYGFR VVISSRFGDI FRGNAGKAGL LAAEVAQDDV
     ELLWKLIEQS PGLEITANLQ DRIITAATVV LPFKIDDHSA WRLLEGLDDI ALTLRKLDEI
     EAFEGACAYW KPRTLPAP
//

If you have problems or comments...

PBIL Back to PBIL home page