(data stored in ACNUC7421 zone)

HOGENOM: MYCTK_1_PE1009

ID   MYCTK_1_PE1009                       STANDARD;      PRT;   223 AA.
AC   MYCTK_1_PE1009; C6DW66;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=2-phospho-L-lactate guanylyltransferase; Short=LP
DE   guanylyltransferase; EC=2.7.7 68; (MYCTK_1.PE1009).
GN   Name=cofC; OrderedLocusNames=TBMG_00986;
OS   MYCOBACTERIUM TUBERCULOSIS KZN 1435.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=478434;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCTK_1.PE1009.
CC       Mycobacterium tuberculosis KZN 1435, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:COFC_MYCTK
CC   -!- FUNCTION: Guanylyltransferase that catalyzes the activation of 2-
CC       phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine
CC       (LPPG), via the condensation of LP with GTP. Is involved in the
CC       biosynthesis of coenzyme F420, a hydride carrier cofactor (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: (2S)-2-phospholactate + GTP = (2S)-lactyl-2-
CC       diphospho-5'-guanosine + diphosphate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme F420 biosynthesis.
CC   -!- SIMILARITY: Belongs to the CofC family.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACT24030.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
CC   -!- GENE_FAMILY: HOG000223639 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6DW66; -.
DR   EMBL; CP001658; ACT24030.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; YP_003030925.1; NC_012943.1.
DR   ProteinModelPortal; C6DW66; -.
DR   STRING; C6DW66; -.
DR   EnsemblBacteria; EBMYCT00000094083; EBMYCP00000091104; EBMYCG00000093296.
DR   GeneID; 8162279; -.
DR   GenomeReviews; CP001658_GR; TBMG_00986.
DR   KEGG; mtb:TBMG_00986; -.
DR   GeneTree; EBGT00050000017164; -.
DR   ProtClustDB; CLSK792205; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   HAMAP; MF_02114; CofC; 1; -.
DR   InterPro; IPR002835; Coenzyme_F420_CofC.
DR   Pfam; PF01983; CofC; 1.
DR   TIGRFAMs; TIGR03552; F420_cofC; 1.
DR   HOGENOMDNA; MYCTK_1.PE1009; -.
KW   hypothetical protein;
KW   Complete proteome; GTP-binding; Nucleotide-binding;
KW   Nucleotidyltransferase; Transferase.
SQ   SEQUENCE   223 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDRRWQDDFM SGTPDDGDIG LIIAVKRLAA AKTRLAPVFS AQTRENVVLA MLVDTLTAAA
     GVGSLRSITV ITPDEAAAAA AAGLGADVLA DPTPEDDPDP LNTAITAAER VVAEGASNIV
     VLQGDLPALQ TQELAEAISA ARHHRRSFVA DRLGTGTAVL CAFGTALHPR FGPDSSARHR
     RSGAVELTGA WPGLRCDVDT PADLTAARQL GVGPATARAV AHR
//

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