(data stored in ACNUC7421 zone)

HOGENOM: MYCTK_1_PE1011

ID   MYCTK_1_PE1011                       STANDARD;      PRT;   358 AA.
AC   MYCTK_1_PE1011; C6DW68;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=D-alanine--D-alanine ligase; EC=6.3.2 4;AltName:
DE   Full=D-Ala-D-Ala ligase;AltName: Full=D-alanylalanine synthetase;
DE   (MYCTK_1.PE1011).
GN   Name=ddl; OrderedLocusNames=TBMG_00988;
OS   MYCOBACTERIUM TUBERCULOSIS KZN 1435.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=478434;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCTK_1.PE1011.
CC       Mycobacterium tuberculosis KZN 1435, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:C6DW68_MYCTK
CC   -!- FUNCTION: Cell wall formation (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 2 D-alanine = ADP + phosphate + D-
CC       alanyl-D-alanine.
CC   -!- COFACTOR: Binds 2 magnesium or manganese ions per subunit (By
CC       similarity).
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the D-alanine--D-alanine ligase family.
CC   -!- SIMILARITY: Contains 1 ATP-grasp domain.
CC   -!- GENE_FAMILY: HOG000011593 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6DW68; -.
DR   EMBL; CP001658; ACT24032.1; -; Genomic_DNA.
DR   RefSeq; YP_003030927.1; NC_012943.1.
DR   ProteinModelPortal; C6DW68; -.
DR   STRING; C6DW68; -.
DR   EnsemblBacteria; EBMYCT00000095744; EBMYCP00000089192; EBMYCG00000093627.
DR   GeneID; 8162281; -.
DR   GenomeReviews; CP001658_GR; TBMG_00988.
DR   KEGG; mtb:TBMG_00988; -.
DR   GeneTree; EBGT00050000015718; -.
DR   ProtClustDB; PRK01966; -.
DR   GO; GO:0005618; C:cell wall; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008716; F:D-alanine-D-alanine ligase activity; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007047; P:cellular cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0009252; P:peptidoglycan biosynthetic process; IEA:HAMAP.
DR   GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-KW.
DR   HAMAP; MF_00047; Dala_Dala_lig; 1; -.
DR   InterPro; IPR011761; ATP-grasp.
DR   InterPro; IPR013815; ATP_grasp_subdomain_1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR000291; D-Ala_lig_Van_CS.
DR   InterPro; IPR005905; D_ala_D_ala.
DR   InterPro; IPR011095; Dala_Dala_lig_C.
DR   InterPro; IPR011127; Dala_Dala_lig_N.
DR   InterPro; IPR013817; Pre-ATP_grasp.
DR   InterPro; IPR016185; PreATP-grasp-like.
DR   Gene3D; G3DSA:3.30.1490.20; ATP_grasp_subdomain_1; 1.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   Gene3D; G3DSA:3.40.50.20; Pre-ATP_grasp; 1.
DR   Pfam; PF07478; Dala_Dala_lig_C; 1.
DR   Pfam; PF01820; Dala_Dala_lig_N; 1.
DR   SUPFAM; SSF52440; PreATP-grasp-like; 1.
DR   TIGRFAMs; TIGR01205; D_ala_D_alaTIGR; 1.
DR   PROSITE; PS50975; ATP_GRASP; 1.
DR   PROSITE; PS00843; DALA_DALA_LIGASE_1; 1.
DR   PROSITE; PS00844; DALA_DALA_LIGASE_2; 1.
DR   HOGENOMDNA; MYCTK_1.PE1011; -.
KW   D-alanyl-alanine synthetase A;
KW   ATP-binding; Cell shape; Cell wall biogenesis/degradation;
KW   Complete proteome; Cytoplasm; Ligase; Magnesium; Manganese;
KW   Metal-binding; Nucleotide-binding; Peptidoglycan synthesis.
SQ   SEQUENCE   358 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFGGRSNEHA ISCVSAGSIL RNLDSRRFDV IAVGITPAGS WVLTDANPDA LTITNRELPQ
     VKSGSGTELA LPADPRRGGQ LVSLPPGAGE VLESVDVVFP VLHGPYGEDG TIQGLLELAG
     VPYVGAGVLA SAVGMDKEFT KKLLAADGLP VGAYAVLRPP RSTLHRQECE RLGLPVFVKP
     ARGGSSIGVS RVSSWDQLPA AVARARRHDP KVIVEAAISG RELECGVLEM PDGTLEASTL
     GEIRVAGVRG REDSFYDFAT KYLDDAAELD VPAKVDDQVA EAIRQLAIRA FAAIDCRGLA
     RVDFFLTDDG PVINEINTMP GFTTISMYPR MWAASGVDYP TLLATMIETA LARGVGLH
//

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