(data stored in SCRATCH3701 zone)

HOGENOM6: MYCVP_1_PE7

ID   MYCVP_1_PE7                          STANDARD;      PRT;   1262 AA.
AC   MYCVP_1_PE7; A1T108;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; EC=5.99.1 3; (MYCVP_1.PE7).
GN   OrderedLocusNames=Mvan_0007;
OS   MYCOBACTERIUM VANBAALENII PYR-1.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=350058;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYCVP_1.PE7.
CC       Mycobacterium vanbaalenii PYR-1, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:A1T108_MYCVP
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A1T108; -.
DR   EMBL; CP000511; ABM10858.1; -; Genomic_DNA.
DR   RefSeq; YP_950864.1; NC_008726.1.
DR   ProteinModelPortal; A1T108; -.
DR   SMR; A1T108; 38-130, 132-238, 499-551.
DR   STRING; A1T108; -.
DR   MEROPS; N10.001; -.
DR   EnsemblBacteria; EBMYCT00000083384; EBMYCP00000081337; EBMYCG00000083379.
DR   GeneID; 4644532; -.
DR   GenomeReviews; CP000511_GR; Mvan_0007.
DR   KEGG; mva:Mvan_0007; -.
DR   eggNOG; COG0188; -.
DR   GeneTree; EBGT00050000016653; -.
DR   OMA; EEYSAQG; -.
DR   ProtClustDB; CLSK701787; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR003586; Hedgehog_hint_C.
DR   InterPro; IPR003587; Hedgehog_hint_N.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_splice_site.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 2.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 2.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   TIGRFAMs; TIGR01443; Intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; Intein_Nterm; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
DR   HOGENOMDNA; MYCVP_1.PE7; -.
DR   PRODOM; MYCVP_1_PE7.
DR   SWISS-2DPAGE; MYCVP_1_PE7.
KW   DNA gyrase, A subunit;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   1262 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDTTLPPGG EAGDRIEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     FDSGFRPDRG HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY CLTGDSMVRL PFGQSVRIGD VVSGARPNSD NEIELKVLDR HGNPVLADAL
     FHSGDHETFT VRTAEGYEVT GTANHPLLCL VDVGGVPTLL WKLIAEIRPS DRVVLQRTPP
     VEFGPADWYE TMEALLLGAF ISEGFVSESR AGFNNLDRDY FNMVVAAYDT VVGGPRYVYE
     RKIASGSTLL ELDIQNLASL RQSRLVGLLG QRSAAKMVPE WLWNSAAAVK RAFLQALFEG
     DGSCSALPRN TIQVSYSTRS GQLAKDVQQM LLEFGVISRR YLHATGEHKV VITNRSSAEA
     FCTRVGFGGA KQHKLQKLLS DLPERAAGLD GDHVPGLAAF IRRESGSKWV DKEWLRKHNI
     DRLSRWRRDG SEILSRIADP DVRAIATELT DGRFYYAEVA TVVSAGVQPV YSLRVDTDDH
     SFISNGFVSH NTEARLTPLA MEMLREIDEE TVDFIPNYDG RVQEPTVLPS RFPNLLANGS
     GGIAVGMATN MPPHNLRELA EAVYWCLENY EADEEATLEA VCERVKGPDF PTHGLIVGSQ
     GISDTYTTGR GSIRMRGVVE IEEDSRGRTS LVITELPYQV NHDNFITSIA EQVRDGKLAG
     ISNIEDQSSD RVGLRIVVEI KRDAVAKVVL NNLYKHTQLQ TSFGANMLSI VDGVPRTLRL
     DQLIRLYVNH QLDVIVRRTT YRLRKANERA HILRGLVKAL DALDEVIALI RASQTVEIAR
     SGLIELLDID EIQAQAILDM QLRRLAALER QRIIDDLAKI EAEIADLEDI LAKPERQRAI
     VHDELKELVD KYGDDRRTRI IPADGDVADE DLIAREEVVV TITETGYAKR TKSDLYRSQK
     RGGKGVQGAG LKQDDIVNHF FVCSTHDWIL FFTTQGRVYR AKAYDLPEAS RTARGQHVAN
     LLAFQPEERI AQVIQLKSYE DAPYLVLATR NGLVKKSRLV DFDSNRSGGI VAVNLRDGDE
     LVGAVLCSAE DDLLLVSAKG QSIRFSATDE ALRPMGRATS GVQGMRFNEE DQLLSLNVVR
     EDTYLLVATS GGYAKRTAIE EYSAQGRGGK GILTIQYDRR RGTLVGALIV DDDTELYAIT
     SGGGVIRTAA RQVRKAGRQT KGVRLMNLGE GDTLIAIARN AEAGDSTDEV NTDPDATDDE
     ES
//

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