(data stored in SCRATCH3701 zone)

HOGENOM6: MYLEP1_1_PE6

ID   MYLEP1_1_PE6                         STANDARD;      PRT;   1249 AA.
AC   MYLEP1_1_PE6; Q57532; Q50209; Q9CDF2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=DNA gyrase subunit A; EC=5.99.1 3;Contains: RecName:
DE   Full=Mle gyrA intein; (MYLEP1_1.PE6).
GN   Name=gyrA; OrderedLocusNames=ML0006;
OS   MYCOBACTERIUM LEPRAE TN.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYLEP1_1.PE6.
CC       Mycobacterium leprae TN chromosome, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:GYRA_MYCLE
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings.
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- PTM: This protein undergoes a protein self splicing that involves
CC       a post-translational excision of the intervening region (intein)
CC       followed by peptide ligation (Potential).
CC   -!- SIMILARITY: Belongs to the topoisomerase GyrA/ParC subunit family.
CC   -!- SIMILARITY: Contains 1 DOD-type homing endonuclease domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC29514.1; Type=Frameshift; Positions=1247;
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q57532; Q50209; Q9CDF2; -.
DR   EMBL; Z70722; CAA94713.1; -; Genomic_DNA.
DR   EMBL; Z68206; CAA92430.1; -; Genomic_DNA.
DR   EMBL; AL583917; CAC29514.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; X87124; CAA60608.1; -; Genomic_DNA.
DR   PIR; F86909; F86909.
DR   PIR; T10006; T10006.
DR   RefSeq; NP_301134.1; NC_002677.1.
DR   ProteinModelPortal; Q57532; -.
DR   SMR; Q57532; 38-130, 132-237, 494-550.
DR   MEROPS; N10.001; -.
DR   EnsemblBacteria; EBMYCT00000028340; EBMYCP00000027946; EBMYCG00000028335.
DR   GeneID; 908154; -.
DR   GenomeReviews; AL450380_GR; ML0006.
DR   KEGG; mle:ML0006; -.
DR   Leproma; ML0006; -.
DR   GeneTree; EBGT00050000016653; -.
DR   ProtClustDB; CLSK701787; -.
DR   BioCyc; MLEP272631:ML0006-MON; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0004519; F:endonuclease activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   GO; GO:0016539; P:intein-mediated protein splicing; IEA:InterPro.
DR   HAMAP; MF_01897; GyrA; 1; -.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR003586; Hedgehog_hint_C.
DR   InterPro; IPR003587; Hedgehog_hint_N.
DR   InterPro; IPR006142; INTEIN.
DR   InterPro; IPR004042; Intein_endonuc.
DR   InterPro; IPR006141; Intein_splice_site.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:2.120.10.30; 6-blade_b-propeller_TolB-like; 1.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 2.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 2.
DR   PRINTS; PR00379; INTEIN.
DR   SMART; SM00305; HintC; 1.
DR   SMART; SM00306; HintN; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 2.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   TIGRFAMs; TIGR01443; Intein_Cterm; 1.
DR   TIGRFAMs; TIGR01445; Intein_Nterm; 1.
DR   PROSITE; PS50818; INTEIN_C_TER; 1.
DR   PROSITE; PS50819; INTEIN_ENDONUCLEASE; 1.
DR   PROSITE; PS50817; INTEIN_N_TER; 1.
DR   HOGENOMDNA; MYLEP1_1.PE6; -.
DR   PRODOM; MYLEP1_1_PE6.
DR   SWISS-2DPAGE; MYLEP1_1_PE6.
KW   putative DNA gyrase subunit A;
KW   ATP-binding; Autocatalytic cleavage; Complete proteome; Cytoplasm;
KW   DNA-binding; Isomerase; Nucleotide-binding; Protein splicing;
KW   Topoisomerase.
SQ   SEQUENCE   1249 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDITLPPGD GSIQRVEPVD IQQEMQRSYI DYAMSVIVGR ALPEVRDGLK PVHRRVLYAM
     LDSGFRPDRS HAKSARSVAE TMGNYHPHGD ASIYDTLVRM AQPWSLRYPL VDGQGNFGSP
     GNDPPAAMRY CVSGNSLVRL LFGKSIRIGD IVTGAQFNSD NPIDLKVLDR HGNPVVADYL
     FHSGEHQTYT VRTTEGYEIT GTSNHPLLCL VNVGGIPTLL WKLIGEIRSG DYVVLQRIPP
     VEFGPADWYS TMEALLFGAF ISGGFVFQDH AGFNSLDRDY FTMVVNAYDT VVGGLRCISS
     RITVSGSTLL ELDVYNLIEF KKTRLSGLCG QRSADKLVPD WLWHSPSTVK RAFLQALFEG
     EGFSSILSRN IIEISYSTLS ERLAADVQQM LLEFGVVSER YCHTVNEYKV VIANRAQVEM
     FFTQVGFGVT KQAKLIRDVV SMSPCVGMDI NCVPGLATFI RKHCDNRWVE EDSFNQHNVD
     CVQHWHHHSA EIVGHIADPD IRAIVTDLTD GRFYYARVAS VTDTGIQPVF SLHVDTEDHS
     FLTNGFISHN TEARLTPLAM EMLREIDEET VDFISNYDGR VQEPMVLPSR FPNLLANGSG
     GIAVGMATNI PPHNLYELAD AVFWCLENHD ADEETMLVAV MERVKGPDFP TAGLIVGSQG
     IADAYKTGRG SIRIRGVVEV EEDSRGRTSL VITELPYQVN HDNFITSIAE QVRTGRLAGI
     SNVEDQGSDR VGVRIVIEIK RDAVAKVVLN NLYKHTQLQT SFGANMLSIV DGVPRTLRLD
     QMICYYVEHQ LDVIVRRTTY RLRKANERAH ILRGLVKALD ALDEVITLIR ASQTVDIARV
     GVVELLDIDD IQAQAILDMQ LRRLAALERQ RIIDDLAKIE VEIADLGDIL AKPERRRGII
     RNELTEIAEK YGDDRRTRII AVDGDVNDED LIAREEVVVT ITETGYAKRT KTDLYRSQKR
     GGKGVQGAGL KQDDIVRHFF VCSTHDWILF FTTQGRVYRA KAYELPEASR TARGQHVANL
     LAFQPEERIA QVIQIRSYED APYLVLATRA GLVKKSKLTD FDSNRSGGIV AINLRDNDEL
     VGAVLCAADG DLLLVSANGQ SIRFSATDEA LRPMGRATSG VQGMRFNADD RLLSLNVVRE
     DTYLLVATSG GYAKRTSIEE YPMQGRGGKG VLTVMYDRRR GSLVGAIVVD EDSELYAITS
     GGGVIRTTAR QVRQAGRQTK GVRLMNLGEG DTLLAIARNA EESADGGVG
//

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