(data stored in ACNUC30630 zone)

HOGENOM: MYLEP1_1_PE786

ID   MYLEP1_1_PE786                       STANDARD;      PRT;   529 AA.
AC   MYLEP1_1_PE786; Q9X7C5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (MYLEP1_1.PE786).
GN   Name=trpE; OrderedLocusNames=ML1269; ORFNames=MLCB1610.31;
OS   MYCOBACTERIUM LEPRAE TN.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYLEP1_1.PE786.
CC       Mycobacterium leprae TN chromosome, complete genome.
CC       chromosome, complete sequence.
CC   -!- ANNOTATIONS ORIGIN:TRPE_MYCLE
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9X7C5; -.
DR   EMBL; AL049913; CAB43177.1; -; Genomic_DNA.
DR   EMBL; AL583921; CAC31650.1; -; Genomic_DNA.
DR   PIR; T45254; T45254.
DR   RefSeq; NP_301914.1; NC_002677.1.
DR   ProteinModelPortal; Q9X7C5; -.
DR   EnsemblBacteria; EBMYCT00000029079; EBMYCP00000028685; EBMYCG00000029074.
DR   GeneID; 910378; -.
DR   GenomeReviews; AL450380_GR; ML1269.
DR   KEGG; mle:ML1269; -.
DR   NMPDR; fig|272631.1.peg.786; -.
DR   Leproma; ML1269; -.
DR   GeneTree; EBGT00050000015088; -.
DR   OMA; RTIYGRA; -.
DR   ProtClustDB; PRK13571; -.
DR   BioCyc; MLEP272631:ML1269-MON; -.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; MYLEP1_1.PE786; -.
KW   anthranilate synthase component I;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Tryptophan biosynthesis.
SQ   SEQUENCE   529 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MHAHLAATTS REDFRQLAVD HRVVPVTRKV LADSETPLSA YRKLAANRPS TFLLESAENG
     RSWSQWSFIG VGAPSALTIR DGEAVWLGTV PQDAPTGGDP LHVLQATLEL LATAAMPGLP
     PLSSGMVGFF AYDMVRRLER LPELALNDLQ LPDMLLLLAT DVAAVDHHEG TITLIANAVN
     WNGTDERVDQ AYDDAIARLD VMTAALGQPL PSTIATFSRP DPRRRAQCTI EEYGAIVDHL
     VDQIAAGEAF QVVPSQRFEV DTDVDPIDVY RMLRVTNPSP YMYLLHVPNS DGATGFSIVG
     SSPEALVTVK DGRVTTHPIA GTRWRGQTEE EDQLLEKELL ADEKERAEHL MLVDLGRNDL
     GRVCTPGTVR VEDYSHVERY SHVMHMVSTV TGLLGEGRTA LDAVTACFPA GTLSGAPKVR
     SMELIEEVEK TRRGLYGGVV GYLDFAGNAD FAIAIRTALM RDGIAYVQAG GGVVADSNGP
     YEYIEASNKA RAVLNAIAAA ETLTSLDFGV ALAPGRVAAR GEAGNQGRL
//

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