(data stored in ACNUC7421 zone)

HOGENOM: MYTUB1_1_PE1267

ID   MYTUB1_1_PE1267                      STANDARD;      PRT;   97 AA.
AC   MYTUB1_1_PE1267; O50461;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Toxin RelE; EC=3.1.- -;AltName: Full=Putative
DE   endoribonuclease RelE; (MYTUB1_1.PE1267).
GN   Name=relE; Synonyms=relE1; OrderedLocusNames=Rv1246c;
OS   MYCOBACTERIUM TUBERCULOSIS H37RV.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYTUB1_1.PE1267.
CC       Mycobacterium tuberculosis H37Rv, complete genome.
CC       1..69269 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RELE_MYCTU
CC   -!- FUNCTION: Toxic component of a toxin-antitoxin (TA) module. Has
CC       RNase activity (By similarity). Overexpression in M.tuberculosis
CC       or M.smegmatis inhibits colony formation in a bacteriostatic
CC       rather than bacteriocidal fashion. Its toxic effect is neutralized
CC       by coexpression with cognate antitoxin RelB (shown only for
CC       M.smegmatis).
CC   -!- FUNCTION: In combination with RelB represses its own promoter. Has
CC       been seen to bind DNA in complex with cognate antitoxin RelB but
CC       not alone.
CC   -!- SUBUNIT: Interacts with cognate antitoxin RelB, which neutralizes
CC       the toxin. Also interacts with non-cognate antitoxin RelF in
CC       vitro, in M.smegmatis coexpression of these 2 genes increases the
CC       toxicity of RelE.
CC   -!- INDUCTION: Expressed in log phase cells (at protein level).
CC       Induced by rifampicin treatment. Expressed in human macrophages
CC       110 hours after infection. Induced in the lungs of mice infected
CC       for 4 weeks. A member of the relBE operon.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype in culture or upon
CC       infection of mice.
CC   -!- SIMILARITY: Belongs to the RelE toxin family.
CC   -!- GENE_FAMILY: HOG000219995 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; O50461; -.
DR   EMBL; BX842576; CAA15902.1; -; Genomic_DNA.
DR   PIR; E70953; E70953.
DR   RefSeq; NP_215762.1; NC_000962.2.
DR   ProteinModelPortal; O50461; -.
DR   EnsemblBacteria; EBMYCT00000000005; EBMYCP00000000005; EBMYCG00000000005.
DR   GeneID; 887099; -.
DR   GenomeReviews; AL123456_GR; Rv1246c.
DR   KEGG; mtu:Rv1246c; -.
DR   TubercuList; Rv1246c; -.
DR   GeneTree; EBGT00050000018419; -.
DR   OMA; HRADAYR; -.
DR   ProtClustDB; CLSK791045; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0045926; P:negative regulation of growth; IMP:MTBBASE.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR007712; Plasmid_stabil.
DR   Pfam; PF05016; Plasmid_stabil; 1.
DR   HOGENOMDNA; MYTUB1_1.PE1267; -.
KW   hypothetical protein;
KW   Complete proteome; DNA-binding; Hydrolase; Nuclease;
KW   Reference proteome; Repressor; Toxin; Transcription;
KW   Transcription regulation.
SQ   SEQUENCE   97 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDDHPYHVA ITATAARDLQ RLPEKIAAAC VEFVFGPLLN NPHRLGKPLR NDLEGLHSAR
     RGDYRVVYAI DDGHHRVEII HIARRSASYR MNPCRPR
//

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