(data stored in ACNUC30630 zone)

HOGENOM: MYTUB2_1_PE15

ID   MYTUB2_1_PE15                        STANDARD;      PRT;   232 AA.
AC   MYTUB2_1_PE15; Q7DAK6; Q79G16;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 2; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component II;AltName: Full=Glutamine
DE   amido-transferase; (MYTUB2_1.PE15).
GN   Name=trpG; OrderedLocusNames=Rv0013, MT0016;
OS   MYCOBACTERIUM TUBERCULOSIS CDC1551.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYTUB2_1.PE15.
CC       Mycobacterium tuberculosis CDC1551, complete genome.
CC       1..69269 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:TRPG_MYCTU
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity (By similarity).
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-1 domain.
CC   -!- GENE_FAMILY: HOG000025029 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q7DAK6; Q79G16; -.
DR   EMBL; BX842572; CAE55234.1; -; Genomic_DNA.
DR   EMBL; AE000516; AAK44238.1; -; Genomic_DNA.
DR   PIR; C70699; C70699.
DR   RefSeq; NP_334424.1; NC_002755.2.
DR   RefSeq; YP_177615.1; NC_000962.2.
DR   ProteinModelPortal; Q7DAK6; -.
DR   EnsemblBacteria; EBMYCT00000000103; EBMYCP00000000103; EBMYCG00000000103.
DR   EnsemblBacteria; EBMYCT00000070459; EBMYCP00000068518; EBMYCG00000070454.
DR   GeneID; 885955; -.
DR   GeneID; 922462; -.
DR   GenomeReviews; AE000516_GR; MT0016.
DR   GenomeReviews; AL123456_GR; Rv0013.
DR   KEGG; mtc:MT0016; -.
DR   KEGG; mtu:Rv0013; -.
DR   TIGR; MT0016; -.
DR   TubercuList; Rv0013; -.
DR   GeneTree; EBGT00050000015859; -.
DR   OMA; EDSTIMA; -.
DR   ProtClustDB; PRK07765; -.
DR   GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR   GO; GO:0004049; F:anthranilate synthase activity; IEA:EC.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR006220; Anth_synthII.
DR   InterPro; IPR001317; CarbamoylP_synth_GATase_dom.
DR   InterPro; IPR011702; GATASE.
DR   InterPro; IPR017926; GATASE_1.
DR   InterPro; IPR006221; TrpG_papA.
DR   Pfam; PF00117; GATase; 1.
DR   PRINTS; PR00097; ANTSNTHASEII.
DR   PRINTS; PR00099; CPSGATASE.
DR   PRINTS; PR00096; GATASE.
DR   TIGRFAMs; TIGR00566; TrpG_papA; 1.
DR   PROSITE; PS51273; GATASE_TYPE_1; 1.
DR   HOGENOMDNA; MYTUB2_1.PE15; -.
KW   para-aminobenzoate synthase component II;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Glutamine amidotransferase; Lyase;
KW   Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   232 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRILVVDNYD SFVFNLVQYL GQLGIEAEVW RNDDHRLSDE AAVAGQFDGV LLSPGPGTPE
     RAGASVSIVH ACAAAHTPLL GVCLGHQAIG VAFGATVDRA PELLHGKTSS VFHTNVGVLQ
     GLPDPFTATR YHSLTILPKS LPAVLRVTAR TSSGVIMAVQ HTGLPIHGVQ FHPESILTEG
     GHRILANWLT CCGWTQDDTL VRRLENEVLT AISPHFPTST ASAGEATGRT SA
//

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