(data stored in ACNUC30630 zone)

HOGENOM: MYTUB2_1_PE1694

ID   MYTUB2_1_PE1694                      STANDARD;      PRT;   516 AA.
AC   MYTUB2_1_PE1694; P67001; O06127;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Anthranilate synthase component 1; EC=4.1.3 27;AltName:
DE   Full=Anthranilate synthase component I; (MYTUB2_1.PE1694).
GN   Name=trpE; OrderedLocusNames=Rv1609, MT1644;
OS   MYCOBACTERIUM TUBERCULOSIS CDC1551.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYTUB2_1.PE1694.
CC       Mycobacterium tuberculosis CDC1551, complete genome.
CC       1..69269 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:TRPE_MYCTU
CC   -!- CATALYTIC ACTIVITY: Chorismate + L-glutamine = anthranilate +
CC       pyruvate + L-glutamate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 1/5.
CC   -!- SUBUNIT: Tetramer of two components I and two components II (By
CC       similarity).
CC   -!- MISCELLANEOUS: Component I catalyzes the formation of anthranilate
CC       using ammonia rather than glutamine, whereas component II provides
CC       glutamine amidotransferase activity.
CC   -!- SIMILARITY: Belongs to the anthranilate synthase component I
CC       family.
CC   -!- GENE_FAMILY: HOG000025142 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P67001; O06127; -.
DR   EMBL; BX842577; CAB08903.1; -; Genomic_DNA.
DR   EMBL; AE000516; AAK45913.1; -; Genomic_DNA.
DR   PIR; G70556; G70556.
DR   RefSeq; NP_216125.1; NC_000962.2.
DR   RefSeq; NP_336099.1; NC_002755.2.
DR   ProteinModelPortal; P67001; -.
DR   EnsemblBacteria; EBMYCT00000000570; EBMYCP00000000570; EBMYCG00000000570.
DR   EnsemblBacteria; EBMYCT00000070003; EBMYCP00000068062; EBMYCG00000069998.
DR   GeneID; 885040; -.
DR   GeneID; 924261; -.
DR   GenomeReviews; AE000516_GR; MT1644.
DR   GenomeReviews; AL123456_GR; Rv1609.
DR   KEGG; mtc:MT1644; -.
DR   KEGG; mtu:Rv1609; -.
DR   TIGR; MT1644; -.
DR   TubercuList; Rv1609; -.
DR   GeneTree; EBGT00050000015088; -.
DR   OMA; PSQRMSM; -.
DR   ProtClustDB; PRK13571; -.
DR   GO; GO:0005886; C:plasma membrane; IDA:MTBBASE.
DR   GO; GO:0004049; F:anthranilate synthase activity; IDA:MTBBASE.
DR   GO; GO:0000287; F:magnesium ion binding; IDA:MTBBASE.
DR   GO; GO:0040007; P:growth; IMP:MTBBASE.
DR   GO; GO:0000162; P:tryptophan biosynthetic process; IDA:MTBBASE.
DR   InterPro; IPR005801; ADC_synthase.
DR   InterPro; IPR019999; Anth_synth_I.
DR   InterPro; IPR006805; Anth_synth_I_N.
DR   InterPro; IPR005256; Anth_synth_I_PabB.
DR   InterPro; IPR015890; Chorismate-bd_C.
DR   Gene3D; G3DSA:3.60.120.10; TRPE_1_chor_bd; 1.
DR   Pfam; PF04715; Anth_synt_I_N; 1.
DR   Pfam; PF00425; Chorismate_bind; 1.
DR   PRINTS; PR00095; ANTSNTHASEI.
DR   SUPFAM; SSF56322; TRPE_1_chor_bd; 1.
DR   TIGRFAMs; TIGR00564; TrpE_most; 1.
DR   HOGENOMDNA; MYTUB2_1.PE1694; -.
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; Lyase; Reference proteome; Tryptophan biosynthesis.
SQ   SEQUENCE   516 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MHADLAATTS REDFRLLAAE HRVVPVTRKV LADSETPLSA YRKLAANRPG TFLLESAENG
     RSWSRWSFIG AGAPTALTVR EGQAVWLGAV PKDAPTGGDP LRALQVTLEL LATADRQSEP
     GLPPLSGGMV GFFAYDMVRR LERLPERAVD DLCLPDMLLL LATDVAAVDH HEGTITLIAN
     AVNWNGTDER VDWAYDDAVA RLDVMTAALG QPLPSTVATF SRPEPRHRAQ RTVEEYGAIV
     EYLVDQIAAG EAFQVVPSQR FEMDTDVDPI DVYRILRVTN PSPYMYLLQV PNSDGAVDFS
     IVGSSPEALV TVHEGWATTH PIAGTRWRGR TDDEDVLLEK ELLADDKERA EHLMLVDLGR
     NDLGRVCTPG TVRVEDYSHI ERYSHVMHLV STVTGKLGEG RTALDAVTAC FPAGTLSGAP
     KVRAMELIEE VEKTRRGLYG GVVGYLDFAG NADFAIAIRT ALMRNGTAYV QAGGGVVADS
     NGSYEYNEAR NKARAVLNAI AAAETLAAPG ANRSGC
//

If you have problems or comments...

PBIL Back to PBIL home page