(data stored in ACNUC1104 zone)

HOGENOM: MYTUB2_1_PE2466

ID   MYTUB2_1_PE2466                      STANDARD;      PRT;   537 AA.
AC   MYTUB2_1_PE2466; P71879; O08222; Q7D7B2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Multidrug resistance protein stp;AltName:
DE   Full=Spectinomycin tetracycline efflux pump; (MYTUB2_1.PE2466).
GN   Name=stp; OrderedLocusNames=Rv2333c, MT2395;
OS   MYCOBACTERIUM TUBERCULOSIS CDC1551.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium
OC   tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS MYTUB2_1.PE2466.
CC       Mycobacterium tuberculosis CDC1551, complete genome.
CC       1..69269 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:STP_MYCTU
CC   -!- FUNCTION: Contributes to spectinomycin and tetracycline
CC       resistance.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
CC       (Potential).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB
CC       family.
CC   -!- GENE_FAMILY: HOG000239124 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; P71879; O08222; Q7D7B2; -.
DR   EMBL; BX842579; CAB02058.1; -; Genomic_DNA.
DR   EMBL; AE000516; AAK46687.1; -; Genomic_DNA.
DR   PIR; F70705; F70705.
DR   RefSeq; NP_216849.1; NC_000962.2.
DR   RefSeq; NP_336873.1; NC_002755.2.
DR   ProteinModelPortal; P71879; -.
DR   EnsemblBacteria; EBMYCT00000001385; EBMYCP00000001385; EBMYCG00000001385.
DR   EnsemblBacteria; EBMYCT00000072160; EBMYCP00000070219; EBMYCG00000072155.
DR   GeneID; 887274; -.
DR   GeneID; 924017; -.
DR   GenomeReviews; AE000516_GR; MT2395.
DR   GenomeReviews; AL123456_GR; Rv2333c.
DR   KEGG; mtc:MT2395; -.
DR   KEGG; mtu:Rv2333c; -.
DR   TIGR; MT2395; -.
DR   TubercuList; Rv2333c; -.
DR   GeneTree; EBGT00050000014781; -.
DR   OMA; THRVIAN; -.
DR   ProtClustDB; CLSK872052; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   InterPro; IPR004638; Drug-R_transpt_efflux_EmrB.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR016196; MFS_dom_general_subst_transpt.
DR   InterPro; IPR001411; Tet-R_TetB/Drug-R_transptr.
DR   Pfam; PF07690; MFS_1; 1.
DR   PRINTS; PR01036; TCRTETB.
DR   SUPFAM; SSF103473; MFS_gen_substrate_transporter; 1.
DR   TIGRFAMs; TIGR00711; Efflux_EmrB; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   HOGENOMDNA; MYTUB2_1.PE2466; -.
KW   drug transporter;
KW   Antibiotic resistance; Cell membrane; Complete proteome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
SQ   SEQUENCE   537 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNRTQLLTLI ATGLGLFMIF LDALIVNVAL PDIQRSFAVG EDGLQWVVAS YSLGMAVFIM
     SAATLADLYG RRRWYLIGVS LFTLGSIACG LAPSIAVLTT ARGAQGLGAA AVSVTSLALV
     SAAFPEAKEK ARAIGIWTAI ASIGTTTGPT LGGLLVDQWG WRSIFYVNLP MGALVLFLTL
     CYVEESCNER ARRFDLSGQL LFIVAVGALV YAVIEGPQIG WTSVQTIVML WTAAVGCALF
     VWLERRSSNP MMDLTLFRDT SYALAIATIC TVFFAVYGML LLTTQFLQNV RGYTPSVTGL
     MILPFSAAVA IVSPLVGHLV GRIGARVPIL AGLCMLMLGL LMLIFSEHRS SALVLVGLGL
     CGSGVALCLT PITTVAMTAV PAERAGMASG IMSAQRAIGS TIGFAVLGSV LAAWLSATLE
     PHLERAVPDP VQRHVLAEII IDSANPRAHV GGIVPRRHIE HRDPVAIAEE DFIEGIRVAL
     LVATATLAVV FLAGWRWFPR DVHTAGSDLS ERLPTAMTVE CAVSHMPGAT WCRLWPA
//

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