(data stored in SCRATCH zone)

HOGENOM: NEIL0_1_PE1008

ID   NEIL0_1_PE1008                       STANDARD;      PRT;   344 AA.
AC   NEIL0_1_PE1008; E4ZD50;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3
DE   1;AltName: Full=AIR synthase;AltName: Full=AIRS;AltName:
DE   Full=Phosphoribosyl-aminoimidazole synthetase; (NEIL0_1.PE1008).
GN   Name=purM; OrderedLocusNames=NLA_10580;
OS   NEISSERIA LACTAMICA 020-06.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=489653;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS NEIL0_1.PE1008.
CC       Neisseria lactamica ST-640, complete genome.
CC       Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:E4ZD50_NEIL0
CC   -!- CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-
CC       ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
CC   -!- GENE_FAMILY: HOG000229091 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; E4ZD50; -.
DR   EMBL; FN995097; CBN87283.1; -; Genomic_DNA.
DR   RefSeq; YP_004048651.1; NC_014752.1.
DR   GeneID; 10005408; -.
DR   GenomeReviews; FN995097_GR; NLA_10580.
DR   KEGG; nla:NLA_10580; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00741_B; AIRS_B; 1; -.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; AIR_synth_C; 1.
DR   SUPFAM; SSF55326; PurM_N-like; 1.
DR   TIGRFAMs; TIGR00878; PurM; 1.
DR   HOGENOMDNA; NEIL0_1.PE1008; -.
KW   phosphoribosylformylglycinamidine cyclo-ligase;
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
SQ   SEQUENCE   344 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSTSLSYRDA GVDIDAGDQL VENIKPFAKR TMRPEVLGDL GGFGALVEIG KKYKNPVLVS
     GTDGVGTKLK LAFDWDKHDT VGIDLVAMSV NDILVQGAEP LFFLDYFACG KLDVPRATDV
     IKGIAQGCEE SGCALIGGET AEMPGMYPVG EYDLAGFAVG VVEKENVITG RSIGAGDVVL
     GLASNGAHSN GYSLIRKIIE RDNPDLDAEF DNGKTLREAV IAPTRLYVKP ILAALEKFTI
     KGMAHITGGG ITENVPRVLP ENTVAQIDAE SWELPKLFQW LQKAGNVETQ EMYRTFNCGI
     GMVVIVAAED ADAVQSFLSG QGETVYRLGC IRERQGNEHQ TQVA
//

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