(data stored in ACNUC7421 zone)

HOGENOM: NEIML_1_PE1004

ID   NEIML_1_PE1004                       STANDARD;      PRT;   344 AA.
AC   NEIML_1_PE1004; C6S772;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Phosphoribosylformylglycinamidine cyclo-ligase; EC=6.3.3
DE   1;AltName: Full=AIR synthase;AltName: Full=AIRS;AltName:
DE   Full=Phosphoribosyl-aminoimidazole synthetase; (NEIML_1.PE1004).
GN   Name=purM; OrderedLocusNames=NMO_1065;
OS   NEISSERIA MENINGITIDIS ALPHA14.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=662598;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS NEIML_1.PE1004.
CC       Neisseria meningitidis alpha14, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C6S772_NEIML
CC   -!- CATALYTIC ACTIVITY: ATP + 2-(formamido)-N(1)-(5-phospho-D-
CC       ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-
CC       phospho-D-ribosyl)glycinamide: step 2/2.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the AIR synthase family.
CC   -!- GENE_FAMILY: HOG000229091 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6S772; -.
DR   EMBL; AM889136; CBA06075.1; -; Genomic_DNA.
DR   RefSeq; YP_003083253.1; NC_013016.1.
DR   ProteinModelPortal; C6S772; -.
DR   EnsemblBacteria; EBNEIT00000015280; EBNEIP00000013685; EBNEIG00000015280.
DR   GeneID; 8221630; -.
DR   GenomeReviews; AM889136_GR; NMO_1065.
DR   GeneTree; EBGT00050000021577; -.
DR   OMA; PENIPRV; -.
DR   ProtClustDB; PRK05385; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004641; F:phosphoribosylformylglycinamidine cyclo-ligase activity; IEA:EC.
DR   GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00741_B; AIRS_B; 1; -.
DR   InterPro; IPR000728; AIR_synth.
DR   InterPro; IPR010918; AIR_synth_C.
DR   InterPro; IPR004733; PurM_cligase.
DR   InterPro; IPR016188; PurM_N-like.
DR   Pfam; PF00586; AIRS; 1.
DR   Pfam; PF02769; AIRS_C; 1.
DR   SUPFAM; SSF56042; AIR_synth_C; 1.
DR   SUPFAM; SSF55326; PurM_N-like; 1.
DR   TIGRFAMs; TIGR00878; PurM; 1.
DR   HOGENOMDNA; NEIML_1.PE1004; -.
KW   ATP-binding; Complete proteome; Cytoplasm; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
SQ   SEQUENCE   344 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSTSLSYRDA GVDIDAGDQL VENIKPFAKR TMRPEVLGDL GGFGALVEIG KKYKNPVLVS
     GTDGVGTKLK LAFDWDKHDT VGIDLVAMSV NDILVQGAEP LFFLDYFACG ELDVPRATDV
     IKGIAQGCEE SGCALIGGET AEMPGMYPVG EYDLAGFAVG VVEKENVITG RSIGAGDVVL
     GLASNGAHSN GYSLIRKIIE RDNPDLDAEF DNSKTLREAV IAPTRLYVKP ILAALEKFTI
     KGMAHITGGG ITENVPRVLP ENTVAQIDAK SWELPKLFQW LQKAGNVETQ EMYRTFNCGI
     GMVVIVAAED ADAVQGLLGE QGETVYRLGL IRERQGDEHQ TQVA
//

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