(data stored in ACNUC7421 zone)

HOGENOM: NEIML_1_PE1007

ID   NEIML_1_PE1007                       STANDARD;      PRT;   197 AA.
AC   NEIML_1_PE1007; C6S775;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GTP cyclohydrolase-2; EC=3.5.4 25;AltName: Full=GTP
DE   cyclohydrolase II; (NEIML_1.PE1007).
GN   Name=ribA; OrderedLocusNames=NMO_1068;
OS   NEISSERIA MENINGITIDIS ALPHA14.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=662598;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS NEIML_1.PE1007.
CC       Neisseria meningitidis alpha14, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:C6S775_NEIML
CC   -!- FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-
CC       ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and
CC       pyrophosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
CC       hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
CC       6-(D-ribitylamino)uracil from GTP: step 1/4.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC   -!- GENE_FAMILY: HOG000115442 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C6S775; -.
DR   EMBL; AM889136; CBA06084.1; -; Genomic_DNA.
DR   RefSeq; YP_003083256.1; NC_013016.1.
DR   EnsemblBacteria; EBNEIT00000013416; EBNEIP00000012819; EBNEIG00000013416.
DR   GeneID; 8221632; -.
DR   GenomeReviews; AM889136_GR; NMO_1068.
DR   GeneTree; EBGT00050000021611; -.
DR   OMA; QGFILYL; -.
DR   ProtClustDB; PRK00393; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:HAMAP.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00179; RibA; 1; -.
DR   InterPro; IPR000926; GTP_CycHdrlaseII_RibA.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   TIGRFAMs; TIGR00505; RibA; 1.
DR   HOGENOMDNA; NEIML_1.PE1007; -.
KW   Complete proteome; GTP-binding; Hydrolase; Metal-binding;
KW   Nucleotide-binding; Riboflavin biosynthesis; Zinc.
SQ   SEQUENCE   197 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSELLNYVAS CRLPTEWGVF TMHGFEEANG QEHVALTVGD FSDGNPVLTR IHSECLTGDA
     LFSRKCDCGP QLEAAMRAVQ TEGRGIIVYL RQEGRGIGLI NKIRAYHLQD QGMDTVEANL
     ALGLPVDARD FRLAQSIYEY LGIRSVKLLT NNPEKIQTLK DAGINVVERI PLHVGENLEN
     KRYLQTKADK LGHLMSE
//

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