(data stored in ACNUC7421 zone)

HOGENOM: NEMEN2_1_PE1014

ID   NEMEN2_1_PE1014                      STANDARD;      PRT;   530 AA.
AC   NEMEN2_1_PE1014; Q9JUQ8; A1IRJ6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Bifunctional purine biosynthesis protein purH;Includes:
DE   RecName: Full=Phosphoribosylaminoimidazolecarboxamide formyltransferase;
DE   EC=2.1.2.3; AltName: Full=AICAR transformylase;Includes: RecName:
DE   Full=IMP cyclohydrolase; EC=3.5.4 10; AltName: Full=ATIC; AltName:
DE   Full=IMP synthase; AltName: Full=Inosinicase; (NEMEN2_1.PE1014).
GN   Name=purH; OrderedLocusNames=NMA1182;
OS   NEISSERIA MENINGITIDIS Z2491.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC   Neisseria.
OX   NCBI_TaxID=122587;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS NEMEN2_1.PE1014.
CC       Neisseria meningitidis Z2491, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:PUR9_NEIMA
CC   -!- CATALYTIC ACTIVITY: 10-formyltetrahydrofolate + 5-amino-1-(5-
CC       phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-
CC       formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
CC   -!- CATALYTIC ACTIVITY: IMP + H(2)O = 5-formamido-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxamide.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-
CC       amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl
CC       THF route): step 1/1.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamide: step 1/1.
CC   -!- DOMAIN: The IMP cyclohydrolase activity resides in the N-terminal
CC       region (By similarity).
CC   -!- SIMILARITY: Belongs to the purH family.
CC   -!- GENE_FAMILY: HOG000230373 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q9JUQ8; A1IRJ6; -.
DR   EMBL; AL157959; CAM08384.1; -; Genomic_DNA.
DR   PIR; H81885; H81885.
DR   RefSeq; YP_002342577.1; NC_003116.1.
DR   ProteinModelPortal; Q9JUQ8; -.
DR   EnsemblBacteria; EBNEIT00000000123; EBNEIP00000000123; EBNEIG00000000123.
DR   GeneID; 907151; -.
DR   GenomeReviews; AL157959_GR; NMA1182.
DR   KEGG; nma:NMA1182; -.
DR   GeneTree; EBGT00050000021537; -.
DR   OMA; FTGTRHF; -.
DR   ProtClustDB; PRK00881; -.
DR   BioCyc; NMEN122587:NMA1182-MON; -.
DR   GO; GO:0003937; F:IMP cyclohydrolase activity; IEA:EC.
DR   GO; GO:0004643; F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity; IEA:EC.
DR   GO; GO:0006188; P:IMP biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00139; PurH; 1; -.
DR   InterPro; IPR024051; AICAR_Tfase_dom.
DR   InterPro; IPR002695; AICARFT_IMPCHas.
DR   InterPro; IPR016193; Cytidine_deaminase-like.
DR   InterPro; IPR011607; MGS-like_dom.
DR   Gene3D; G3DSA:3.40.140.20; G3DSA:3.40.140.20; 2.
DR   Gene3D; G3DSA:3.40.50.1380; MGS-like_dom; 1.
DR   PANTHER; PTHR11692; AICARFT_IMPCHas; 1.
DR   Pfam; PF01808; AICARFT_IMPCHas; 1.
DR   Pfam; PF02142; MGS; 1.
DR   PIRSF; PIRSF000414; AICARFT_IMPCHas; 1.
DR   SMART; SM00798; AICARFT_IMPCHas; 1.
DR   SMART; SM00851; MGS; 1.
DR   SUPFAM; SSF53927; Cytidine_deaminase-like; 1.
DR   SUPFAM; SSF52335; MGS-like_dom; 1.
DR   TIGRFAMs; TIGR00355; PurH; 1.
DR   HOGENOMDNA; NEMEN2_1.PE1014; -.
KW   Complete proteome; Hydrolase; Multifunctional enzyme;
KW   Purine biosynthesis; Transferase.
SQ   SEQUENCE   530 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPSIKRALIS LSDKTGAVEF AQTLHKLGVE ILSTGGTAKL LADAGVPVIE VADYTGFPEM
     LDGRVKTLHP KIHGGILGRR DLPEHVAKME EHGIGNIDLV CVNLYPFAAT IAKPNCTLED
     AIENIDIGGP TMVRSAAKNW KHVAIVTDPA DFPAIAAEME ANNGALSDKT RFNLSRKAFS
     HTAQYDGMIS NYLTSLSDDV LSGTPEIGEF PSQFNQSWIK VQDMRYGENP HQRAAFYRDV
     YPAAGSLSAY KQLQGKELSY NNIADADAAW EAVKSFDAPA CVIVKHANPC GVAVAADTLT
     AYKLAYATDT TSAFGGIIAF NREVDGETVK QITDNQFMEV LMAPKFTAEA LEIAAAKKNV
     RVLQISLTTP LEAGANRFEL KRVGGGLLVQ TPDIYRLNRA DLKVVSKRQL TEQEWNDLMF
     VWNVAKYVKS NAIVFGKGGQ TYGIGAGQMS RVDSTRIAAR KAQDANLDLN GACAASDAFF
     PFRDGVDVIA EQGIKAIIHP AGSMRDQEVF DAADEHGIAM VVTGVRHFRH
//

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