(data stored in ACNUC14238 zone)

HOGENOM: NEUCR_101_PE109

ID   NEUCR_101_PE109                      STANDARD;      PRT;   163 AA.
AC   NEUCR_101_PE109; P38672; Q7RVF1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Eukaryotic translation initiation factor 5A;
DE   Short=eIF-5A;AltName: Full=eIF-4D; (NEUCR_101.PE109).
GN   Name=tif-51; ORFNames=NCU05274;
OS   NEUROSPORA CRASSA.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=5141;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS NEUCR_101.PE109.
CC       Neurospora crassa supercontig 7.19 EF1 full sequence 1..674492 annotate
CC       Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:IF5A_NEUCR
CC   -!- FUNCTION: mRNA-binding protein involved in translation elongation.
CC       Has an important function at the level of mRNA turnover, probably
CC       acting downstream of decapping. Involved in actin dynamics and
CC       cell cycle progression, mRNA decay and probably in a pathway
CC       involved in stress response and maintenance of cell wall
CC       integrity. Functions as a regulator of apoptosis (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- PTM: eIF-5A seems to be the only eukaryotic protein to have an
CC       hypusine residue which is a post-translational modification of a
CC       lysine by the addition of a butylamino group (from spermidine).
CC   -!- SIMILARITY: Belongs to the eIF-5A family.
CC   -!- GENE_FAMILY: HOG000106270 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Neurospora_crassa;EFNCRG00000004936;EFNCRT00000004942;EFNCRP00000004938.
DR   UniProtKB/Swiss-Prot; P38672; Q7RVF1; -.
DR   EMBL; U02638; AAA61707.1; -; mRNA.
DR   EMBL; AABX02000019; EAA32675.2; -; Genomic_DNA.
DR   PIR; S55278; S55278.
DR   RefSeq; XP_961911.2; XM_956818.2.
DR   UniGene; Ncr.9233; -.
DR   ProteinModelPortal; P38672; -.
DR   SMR; P38672; 22-157.
DR   STRING; P38672; -.
DR   EnsemblFungi; EFNCRT00000004942; EFNCRP00000004938; EFNCRG00000004936.
DR   GeneID; 3878064; -.
DR   KEGG; ncr:NCU05274; -.
DR   eggNOG; fuNOG08157; -.
DR   GeneTree; EFGT00050000003235; -.
DR   OMA; ISAMNEE; -.
DR   OrthoDB; EOG4B01ZQ; -.
DR   PhylomeDB; P38672; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043022; F:ribosome binding; IEA:InterPro.
DR   GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008612; P:peptidyl-lysine modification to hypusine; IEA:InterPro.
DR   GO; GO:0045901; P:positive regulation of translational elongation; IEA:InterPro.
DR   GO; GO:0045905; P:positive regulation of translational termination; IEA:InterPro.
DR   GO; GO:0006452; P:translational frameshifting; IEA:InterPro.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR016027; NA-bd_OB-fold-like.
DR   InterPro; IPR019769; Trans_elong_IF5A_hypusine_site.
DR   InterPro; IPR001884; Transl_elong_IF5A.
DR   InterPro; IPR020189; Transl_elong_IF5A_C.
DR   InterPro; IPR014722; Transl_SH3-like_sub.
DR   InterPro; IPR008991; Translation_prot_SH3-like.
DR   Gene3D; G3DSA:2.40.50.140; OB_NA_bd_sub; 1.
DR   Gene3D; G3DSA:2.30.30.30; Ribosomal_L2; 1.
DR   PANTHER; PTHR11673; EIF5A_hypusine; 1.
DR   Pfam; PF01287; eIF-5a; 1.
DR   Pfam; PF00467; KOW; 1.
DR   PIRSF; PIRSF003025; eIF5A; 1.
DR   SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR   SUPFAM; SSF50104; Transl_SH3_like; 1.
DR   TIGRFAMs; TIGR00037; EIF_5A; 1.
DR   PROSITE; PS00302; IF5A_HYPUSINE; 1.
DR   HOGENOMDNA; NEUCR_101.PE109; -.
KW   EFNCRG00000004936g.scaffold_90100000011;
KW   P38672;
KW   Complete proteome; Cytoplasm; Elongation factor; Hypusine;
KW   Protein biosynthesis; Reference proteome; RNA-binding.
SQ   SEQUENCE   163 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSAAHDDAQH EHTFDSVDAG ASATYPMQCS ALRKGGHVVI KNRPCKIVDM STSKTGKHGH
     AKVHLVAIDI FTGKKLEDLC PSTHNMDVPN VKRTDYQFSY IDEDFLVLID SNGEEKRDVK
     MPEGELAKRI EKLEEEGKDF FVGVQTAMGE EAAIDVKEAS NKD
//

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