(data stored in ACNUC3659 zone)

HOVERGEN: O70500_RAT

ID   O70500_RAT              Unreviewed;       247 AA.
AC   O70500;
DT   01-AUG-1998, integrated into UniProtKB/TrEMBL.
DT   01-AUG-1998, sequence version 1.
DT   03-NOV-2009, entry version 60.
DE   SubName: Full=Vascular chymase;
GN   Name=Mcpt1; Synonyms=VCH;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley; TISSUE=Pulmonary artery;
RX   MEDLINE=21153933; PubMed=11254670; DOI=10.1172/JCI9997;
RA   Guo C., Ju H., Leung D., Massaeli H., Shi M., Rabinovitch M.;
RT   "A novel vascular smooth muscle chymase is upregulated in hypertensive
RT   rats.";
RL   J. Clin. Invest. 107:703-715(2001).
CC   -!- SIMILARITY: Belongs to the peptidase S1 family.
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CC   -!- GENE_FAMILY: HBG013304 [ FAMILY / ALN / TREE ]
DR   EMBL; AF063851; AAC16657.1; -; mRNA.
DR   IPI; IPI00199419; -.
DR   RefSeq; NP_058841.1; -.
DR   UniGene; Rn.202971; -.
DR   HSSP; P00770; 3RP2.
DR   MEROPS; S01.095; -.
DR   Ensembl; ENSRNOT00000027931; ENSRNOP00000027931; ENSRNOG00000020582; Rattus norvegicus.
DR   GeneID; 29265; -.
DR   KEGG; rno:29265; -.
DR   UCSC; NM_017145; rat.
DR   CTD; 29265; -.
DR   HOVERGEN; O70500; -.
DR   NextBio; 608600; -.
DR   Genevestigator; O70500; -.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; NAS:RGD.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   InterPro; IPR018114; Peptidase_S1/S6_AS.
DR   InterPro; IPR001254; Peptidase_S1_S6.
DR   InterPro; IPR001314; Peptidase_S1A.
DR   InterPro; IPR009003; Ser/Cys_Pept_Trypsin-like.
DR   Pfam; PF00089; Trypsin; 1.
DR   PRINTS; PR00722; CHYMOTRYPSIN.
DR   SMART; SM00020; Tryp_SPc; 1.
DR   PROSITE; PS50240; TRYPSIN_DOM; 1.
DR   PROSITE; PS00134; TRYPSIN_HIS; 1.
DR   PROSITE; PS00135; TRYPSIN_SER; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; O70500.
DR   SWISS-2DPAGE; O70500.
KW   Hydrolase; Protease; Serine protease.
FT   DOMAIN        1     65       PRODOM:2005.1:PD474467  1445
FT   DOMAIN       71    114       PRODOM:2005.1:PD331626  438
FT   DOMAIN      115    151       PRODOM:2005.1:PD701657  461
FT   DOMAIN      152    189       PRODOM:2005.1:PD887239  32
FT   DOMAIN      200    239       PRODOM:2005.1:PD000068  1525
SQ   SEQUENCE   247 AA;  27278 MW;  FF913C1103D6D9F9 CRC64;
     MQALLFLMAL LLPSGAGAEE IIGGVESIPH SRPYMAHLDI ITERGLKDSC GGFLITRQFV
     LTAAHCRGRE ITVTLGAHDV SKREYTQQKI KVEKQFIHKN YNFLPNLHDI MLLKLEKQVE
     LTPAVDVVPL PSPSDFIHPG TLCWTAGWGR TGVKDPTSDT LREVALRIMD EEACKIYRHY
     DNNFQVCVGL STRLQTAYTG DSGGPLLCAG VVHGIVSYGH PDATPPAVFT RIAPYVPWIN
     TVLRESS
//

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