(data stored in SCRATCH3701 zone)

HOGENOM6: ORITB_1_PE137

ID   ORITB_1_PE137                        STANDARD;      PRT;   905 AA.
AC   ORITB_1_PE137; A5CCC3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A protein; EC=5.99.1 3; (ORITB_1.PE137).
GN   Name=gyrA; OrderedLocusNames=OTBS_0252;
OS   ORIENTIA TSUTSUGAMUSHI STR. BORYONG.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=357244;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ORITB_1.PE137.
CC       Orientia tsutsugamushi Boryong, complete genome.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:A5CCC3_ORITB
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A5CCC3; -.
DR   EMBL; AM494475; CAM79318.1; -; Genomic_DNA.
DR   RefSeq; YP_001248224.1; NC_009488.1.
DR   STRING; A5CCC3; -.
DR   GeneID; 5218577; -.
DR   GenomeReviews; AM494475_GR; OTBS_0252.
DR   KEGG; ots:OTBS_0252; -.
DR   eggNOG; COG0188; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   BioCyc; OTSU357244:OTBS_0252-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:EC.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; ORITB_1.PE137; -.
DR   PRODOM; ORITB_1_PE137.
DR   SWISS-2DPAGE; ORITB_1_PE137.
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   905 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSEQEYKESN INIISIKEEM QRSYLDYAMS VIVSRALPDV RDGLKPVHRR VLYAMYESGY
     HYNKQYRKSA RVVGDVIGKY HPHGELAVYD SLVRMAQDFS LRLPLVDGQG NFGSMDGDAA
     AAMRYTEVRL KKVAHSLLED INKDTVDFQA NYDGLEQEPK VLPAGFPNLL VNGTGGIAVG
     MATNIPPHNL CEVVDACCAY IDNNNITIIE LMELVKGPDF PTGGQIIGTF GIKSAYNTGR
     GKIIVRGKTD IESDSLKHAI IITEIPFMVN KASLVEKIAE LVNDKRIEGI SAIRDESNKS
     GIRVVIELKK HANTDLILNQ LYSYTSLQTT FNVMMLALDQ GIPKTMTLKD IIVAFTNFRE
     EVITKRTIFL LNKARDKAHI LVGIIIAVSN IDEVIKIIRS SANSEEAKSR LMARMWNVSD
     VYDLVKLVDD RAILKEDGQC FLTEQQTKSI LELRLQRLTN TERGKVEDEL NNLVKEIKAY
     LEILGSRDKL LETMKFELNQ IKEQFSTARL TTIENQEFEQ DIEDLIPEEE VVVTVTLAGY
     IKRVPLSTYR AQKRGGKGRV GSSVQNEDVI THLFIENTHT SILFFSNIGQ VYNLKVYKLP
     LGTPQSKGRP IINLISIKEN ETITNIMPMP AESENDSEKK YIIFATKHGN IRRNDLSDFK
     HIASNGKIAI RLDEGDSLIS VKSCDEENHV LLATQNGKAI RFPVKDLRVF KSRTSDGVKA
     IKLAGNDAVI SMTILKGINC SLEVRENYLN LPVSNRLLIA KNKLLHPSID LSKYNLTEDE
     MLTMASNEEF ILTVSENGYG KFSSAYEYRV TKRGGKGVAN MNVSSKTGKV VSVLPACQDN
     ELMLITSSGK LIRCQLNSVR IIGRSTSGVI LFKTSKDEKV VSIDTIKDTD YSDDCSDDES
     NNNNI
//

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