(data stored in SCRATCH3701 zone)

HOGENOM6: ORITI_1_PE1379

ID   ORITI_1_PE1379                       STANDARD;      PRT;   905 AA.
AC   ORITI_1_PE1379; B3CTZ0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=DNA gyrase subunit A; (ORITI_1.PE1379).
GN   Name=gyrA; OrderedLocusNames=OTT_1379;
OS   ORIENTIA TSUTSUGAMUSHI STR. IKEDA.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Orientia.
OX   NCBI_TaxID=334380;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS ORITI_1.PE1379.
CC       Orientia tsutsugamushi str. Ikeda, complete genome.
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:B3CTZ0_ORITI
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B3CTZ0; -.
DR   EMBL; AP008981; BAG40837.1; -; Genomic_DNA.
DR   RefSeq; YP_001938071.1; NC_010793.1.
DR   STRING; B3CTZ0; -.
DR   GeneID; 6337223; -.
DR   GenomeReviews; AP008981_GR; OTT_1379.
DR   KEGG; ott:OTT_1379; -.
DR   OMA; TGRGRIY; -.
DR   ProtClustDB; PRK05560; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; ORITI_1.PE1379; -.
DR   PRODOM; ORITI_1_PE1379.
DR   SWISS-2DPAGE; ORITI_1_PE1379.
KW   DNA gyrase subunit A;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   905 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSEQEYKESN INIISIKEEM QRSYLDYAMS VIVSRALPDV RDGLKPVHRR VLYAMYESGY
     HYNKQYRKSA RVVGDVIGKY HPHGELAVYD SLVRMAQDFS LRLPLVDGQG NFGSMDGDAA
     AAMRYTEVRL KKVAHSLLED INKDTVDFQA NYDGLEQEPK VLPAGFPNLL VNGTGGIAVG
     MATNIPPHNL CEVVDACCAY IDNNDITIIE LMELVKGPDF PTGGQIIGTF GIKSAYNTGR
     GKIIVRGKTD IESDSLKHAI IITEIPFMVN KASLVEKIAE LVNDKKIEGI STIRDESNKS
     GIRVVIELKK HANTDLILNQ LYSYTSLQTT FNVMMLALDQ GIPKTMTLKD IIVAFTNFRE
     EVITKRTIFL LNKARDKAHI LVGIIIAVSN IDEVIKIIRS SANSEEAKSR LMARMWNISD
     VYDLVKLVDD RAILKEDGQC FLTEQQTKSI LELRLQRLTN TERGKVEDEL NNLVKEIKAY
     LEILGSRDKL LETMKFELNQ IKEQFSTTRL TTIENQEFEQ DIEDLIPEEE VVVTVTLAGY
     IKRVPLSTYR AQKRGGKGRV GSSVQNEDVI THLFIENTHT SILFFSNIGQ VYNLKVYKLP
     LGTPQSKGRP IINLISIKEN ETITNIMPMP AESENDSEKK YIIFATKHGN IRRNDLSDFK
     HIASNGKIAI RLDEGDSLIS VKSCDEGNHV LLATQNGKAI RFPVKDLRVF KSRTSDGVKA
     IKLAANDAVI SMTILKGINC SLEVRENYLN LPVNNRLLIA KNKSLQPNID LSKYNLTEDE
     MLTMASNEEF ILTVSENGYG KFSSAYEYRV TKRGGKGIAN MNVSPKTGKV VSVLSACQDN
     ELMLITSSGK LIRCQLNSVR IIGRSTSGVI LFKTSKDEKV VSIDTIKDTD YSDDCSDDES
     NNNNS
//

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