(data stored in ACNUC31108 zone)

HOGENOM: PANTR11_3_PE24

ID   PANTR11_3_PE24                       STANDARD;      PRT;   225 AA.
AC   PANTR11_3_PE24; P60034; P18582;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=CD81 antigen;AltName: Full=26 kDa cell surface protein
DE   TAPA-1;AltName: Full=Target of the antiproliferative antibody 1;AltName:
DE   CD_antigen=CD81; (PANTR11_3.PE24).
GN   Name=CD81; Synonyms=TAPA1;
OS   PAN TROGLODYTES.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Pan.
OX   NCBI_TaxID=9598;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PANTR11_3.PE24.
CC       Pan troglodytes chromosome 11 CHIMP2.1 partial sequence 1986057..298605
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD81_PANTR
CC   -!- FUNCTION: May play an important role in the regulation of lymphoma
CC       cell growth. Interacts with a 16-kDa Leu-13 protein to form a
CC       complex possibly involved in signal transduction. May acts a the
CC       viral receptor for HCV.
CC   -!- SUBUNIT: Interacts directly with IGSF8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- PTM: Not glycosylated (Probable).
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Pan_troglodytes;ENSPTRG00000003177;ENSPTRT00000007041;ENSPTRP00000006494.
DR   EMBL; AF116600; - ;
DR   UniProtKB/Swiss-Prot; P60034; P18582; -.
DR   EMBL; AF116600; AAD11440.1; -; mRNA.
DR   RefSeq; NP_001009023.1; NM_001009023.1.
DR   UniGene; Ptr.6131; -.
DR   ProteinModelPortal; P60034; -.
DR   SMR; P60034; 113-200.
DR   STRING; P60034; -.
DR   GeneID; 449635; -.
DR   KEGG; ptr:449635; -.
DR   CTD; 975; -.
DR   eggNOG; prNOG11124; -.
DR   GeneTree; ENSGT00590000082836; -.
DR   OrthoDB; EOG4X97J1; -.
DR   GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
DR   GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; PANTR11_3.PE24; -.
KW   ENSPTRG00000003177-2caffold_90100000011;
KW   CD81_PANTR; AF116600;
KW   Disulfide bond; Membrane; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   225 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     FLFFLFSFFF FLAGGVILGV ALWLRHDPQT TNLLYLELGD KPAPNTFYVG IYILIAVGAV
     MMFVGFLGCY GAIQESQCLL GTFFTCLVIL FACEVAAGIW GFVNKDQIAK DVKQFYDQAL
     QQAVVDDDAN NAKAVVKTFH ETLDCCGSST LTALTTSVLK NNLCPSGSNI ISNLFKEDCH
     QKIDDLFSGK LYLIGIAAIV VAVIMIFEMI LSMVLCCGIR NSSVY
//

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