(data stored in ACNUC8465 zone)

HOGENOM: PANTR15_68_PE4

ID   PANTR15_68_PE4                       STANDARD;      PRT;   393 AA.
AC   PANTR15_68_PE4; Q9XT09;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1;
DE   Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 1;AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;
DE   (PANTR15_68.PE4).
GN   Name=MAP2K1; Synonyms=MEK1, PRKMK1;
OS   PAN TROGLODYTES.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Homininae; Pan.
OX   NCBI_TaxID=9598;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PANTR15_68.PE4.
CC       Pan troglodytes chromosome 15 CHIMP2.1 partial sequence 63962482..64895
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K1_PANTR
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates ERK1 and ERK2 MAP kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with MORG1. Interacts with ARRB2. Found in a
CC       complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By
CC       similarity).
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Pan_troglodytes;ENSPTRG00000007193;ENSPTRT00000013275;ENSPTRP00000012302.
DR   EMBL; AF143201; - ;
DR   UniProtKB/Swiss-Prot; Q9XT09; -.
DR   EMBL; AF143201; AAD33901.1; -; mRNA.
DR   RefSeq; NP_001009071.1; NM_001009071.1.
DR   UniGene; Ptr.6272; -.
DR   ProteinModelPortal; Q9XT09; -.
DR   SMR; Q9XT09; 62-382.
DR   STRING; Q9XT09; -.
DR   GeneID; 450188; -.
DR   KEGG; ptr:450188; -.
DR   CTD; 5604; -.
DR   eggNOG; prNOG13928; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q9XT09; -.
DR   OrthoDB; EOG4SF965; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   HOGENOMDNA; PANTR15_68.PE4; -.
KW   ENSPTRG00000007193-2caffold_90100000011;
KW   MP2K1_PANTR; AF143201;
KW   ATP-binding; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Serine/threonine-protein kinase; Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   393 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV
     GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE
     CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL
     REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY
     SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELMFGCQVE GDAAETPPRP RTPGRPLSSY
     GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF
     IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA AGV
//

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