(data stored in SCRATCH3701 zone)

HOGENOM6: PHPRO1_2_PE2383

ID   PHPRO1_2_PE2383                      STANDARD;      PRT;   894 AA.
AC   PHPRO1_2_PE2383; Q6LPD8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=Putative DNA topoisomerase (PHPRO1_2.PE2383)
DE   (ATP-hydrolyzing); .
GN   Name=GYRA; OrderedLocusNames=PBPRA2456;
OS   PHOTOBACTERIUM PROFUNDUM SS9.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Photobacterium.
OX   NCBI_TaxID=298386;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PHPRO1_2.PE2383.
CC       Photobacterium profundum SS9 chromosome 1, complete genome.
CC       1..336963 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:Q6LPD8_PHOPR
CC   -!- FUNCTION: DNA gyrase negatively supercoils closed circular double-
CC       stranded DNA in an ATP-dependent manner and also catalyzes the
CC       interconversion of other topological isomers of double-stranded
CC       DNA rings, including catenanes and knotted rings (By similarity).
CC   -!- CATALYTIC ACTIVITY: ATP-dependent breakage, passage and rejoining
CC       of double-stranded DNA.
CC   -!- SUBUNIT: Made up of two chains. The A chain is responsible for DNA
CC       breakage and rejoining; the B chain catalyzes ATP hydrolysis. The
CC       enzyme forms an A2B2 tetramer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- GENE_FAMILY: HOG000076278 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q6LPD8; -.
DR   EMBL; CR378671; CAG20838.1; -; Genomic_DNA.
DR   RefSeq; YP_130640.1; NC_006370.1.
DR   HSSP; P09097; 1AB4.
DR   ProteinModelPortal; Q6LPD8; -.
DR   SMR; Q6LPD8; 30-521, 534-847.
DR   GeneID; 3122365; -.
DR   GenomeReviews; CR354531_GR; PBPRA2456.
DR   KEGG; ppr:PBPRA2456; -.
DR   NMPDR; fig|298386.1.peg.4728; -.
DR   OMA; TGRGRIY; -.
DR   PhylomeDB; Q6LPD8; -.
DR   BioCyc; PPRO298386:PBPRA2456-MONOMER; -.
DR   GO; GO:0005694; C:chromosome; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003918; F:DNA topoisomerase (ATP-hydrolyzing) activity; IEA:InterPro.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR   InterPro; IPR020899; Arg_repress_C.
DR   InterPro; IPR005743; GyrA.
DR   InterPro; IPR006691; GyrA/parC_pinwhl.
DR   InterPro; IPR002205; Topo_IIA_A/C.
DR   InterPro; IPR013758; Topo_IIA_A/C_ab.
DR   InterPro; IPR013757; Topo_IIA_A_a.
DR   InterPro; IPR013760; Topo_IIA_cen.
DR   Gene3D; G3DSA:3.30.1360.40; Arg_repress; 1.
DR   Gene3D; G3DSA:3.90.199.10; Topo_IIA_A/C_ab; 1.
DR   Gene3D; G3DSA:1.10.268.10; Topo_IIA_A_a; 1.
DR   Pfam; PF03989; DNA_gyraseA_C; 6.
DR   Pfam; PF00521; DNA_topoisoIV; 1.
DR   SMART; SM00434; TOP4c; 1.
DR   SUPFAM; SSF56719; Topo_IIA_cen; 1.
DR   TIGRFAMs; TIGR01063; GyrA; 1.
DR   HOGENOMDNA; PHPRO1_2.PE2383; -.
DR   PRODOM; PHPRO1_2_PE2383.
DR   SWISS-2DPAGE; PHPRO1_2_PE2383.
KW   putative DNA topoisomerase (ATP-hydrolyzing);
KW   ATP-binding; Complete proteome; Cytoplasm; DNA-binding; Isomerase;
KW   Nucleotide-binding; Topoisomerase.
SQ   SEQUENCE   894 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSDLAKEITP VNIEDELKSS YLDYAMSVIV GRALPDVRDG LKPVHRRVLF AMNVLGNDWN
     KAYKKSARVV GDVIGKYHPH GDSAVYDTIV RMAQPFSLRY MLVDGQGNFG SVDGDSAAAM
     RYTEIRMSKI AHELLADLDK ETVDYVPNYD GTEFIPVVMP TRVPNLLVNG SSGIAVGMAT
     NIPPHNLGEV INGCLAFIDN EDITVEQLMD YIPGPDFPTA ALINGRKGII DAYHTGRGKV
     YMRAKANIEV EKNGRETIIV TEIPYQVNKA RLIEKIAELV KDKKVEGISA LRDESDKDGM
     RIVVECKRDA VGEVILNNLY SQTQLQTTFG INMVALDHGQ PKLFGLKEML KCFVNHRREV
     VTRRTIFELR KARERAHLLE GLAIALVNID AIIELIKSAP TPQVAREGLL ASPWQLGDVA
     AMLERGGVDA ARPEWLEPQY GIHGGQYFLT EPQAQAILEL RLHRLTGLEH EKILEEYKGL
     LDVIEELLLI LGSPERLMEV IRDELHAVKE QFNDERRTEI TAASHDIDLE DLITQEDVVV
     TLSHEGYVKY QILSDYEAQR RGGKGKIATR MKDEDFIERL LVANTHDTIL CFSSRGRMYW
     LKVYQLPLAS RTARGKPIVN ILPLEEGERI TAILPVREYE ADKYVFMATA DGTVKKTPLT
     DFSRPRSAGI IAVNLRDGDS LIGVDITNST DDIMLFSKFG KVVRFYESAD ENGKGGVRGM
     GRTAAGVRGM KLAAGDKVVS LIVPHNEGDV LTVTENGYGK RTALTEYPAK SRATQGVVSI
     KVSDRNGSVV GAVQAEDGDE FMMITNGGTL VRTRVAEVSR VGRNTQGVTL IRTADKELVV
     GLQRIDELEV VELEEDAIVD GDVEVAVDGE QVVDTDAAQQ PEADSEQGES TDEE
//

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