(data stored in ACNUC7421 zone)

HOGENOM: PICPG_1_PE1338

ID   PICPG_1_PE1338                       STANDARD;      PRT;   411 AA.
AC   PICPG_1_PE1338; C4QYS6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (PICPG_1.PE1338).
GN   Name=MRI1; OrderedLocusNames=PAS_chr1-4_0545;
OS   KOMAGATAELLA PASTORIS GS115.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Pichia.
OX   NCBI_TaxID=644223;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PICPG_1.PE1338.
CC       Pichia pastoris GS115 chromosome 1, complete sequence
CC       1..3612 annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:MTNA_PICPG
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; C4QYS6; -.
DR   EMBL; FN392319; CAY68400.1; -; Genomic_DNA.
DR   RefSeq; XP_002490680.1; XM_002490635.1.
DR   ProteinModelPortal; C4QYS6; -.
DR   STRING; C4QYS6; -.
DR   GeneID; 8197676; -.
DR   GenomeReviews; FN392319_GR; PAS_chr1-4_0545.
DR   KEGG; ppa:PAS_chr1-4_0545; -.
DR   OrthoDB; EOG4S1XGM; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IEA:EC.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; PICPG_1.PE1338; -.
KW   CAY68400.13GW1.C_3820036002503210000011;
KW   Methylthioribose-1-phosphate isomerase;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus.
SQ   SEQUENCE   411 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSLQAIKFDR QKTRLDILDQ LLIPYQTKYI QVSNIDDGYS VIQKMQVRGA PAIAIVGSFS
     ITCELNSVKD GQKNNHGYDV SDLSVFKAAL EKRIDYLIKS RPTAVNLVNA CTAIKAIVET
     ACTIDDLYAE VLRYSVVLFE DDLKNNYRIG ANGVRYIDNE LSNFEGPFAV MTICNTGSLA
     TSGHGTALGI IRSLWAKSKA NPRNADDKTI QGQKSWLSHV YACETRPYNQ GSRLTSYELN
     FEKIPFSLIT DNMPAYLIDS LFSQRVNCPL PSRAPVKFII VGADRIVTNG DLANKIGTFQ
     LALIASQYDG VKFIGAAPTT TIDYTRDSGD DIVIEQRPAN ELTSILGGQV DSSDQFVTDS
     EGKVNLLRIK TATPNIDVWN PAFDVTPNRL IDSIVTEQDY LVKDSHGKFN L
//

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