(data stored in ACNUC17492 zone)

HOGENOM: PIG10_2_PE7

ID   PIG10_2_PE7                          STANDARD;      PRT;   212 AA.
AC   PIG10_2_PE7; Q3S853; Q2V8V0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 2; Short=RGS2;
DE   (PIG10_2.PE7).
GN   Name=RGS2;
OS   SUS SCROFA.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Laurasiatheria; Cetartiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PIG10_2.PE7.
CC       Sus scrofa chromosome 10 Sscrofa9 partial sequence 1000001..2000000
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS2_PIG
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. May play a role in leukemogenesis.
CC       Binds EIF2B5 and blocks its activity, thereby inhibiting the
CC       translation of mRNA into protein (By similarity).
CC   -!- SUBUNIT: Interacts with EIF2B5 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane (By similarity). Cytoplasm (By
CC       similarity). Nucleus, nucleolus (By similarity).
CC   -!- PTM: Phosphorylated by protein kinase C (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Sus_scrofa;ENSSSCG00000010806;ENSSSCT00000011822;ENSSSCP00000011519.
DR   EMBL; DQ150111; - ;
DR   EMBL; DQ285660; - ;
DR   UniProtKB/Swiss-Prot; Q3S853; Q2V8V0; -.
DR   EMBL; DQ285660; ABB89038.1; -; Genomic_DNA.
DR   EMBL; DQ150111; AAZ94412.2; -; mRNA.
DR   RefSeq; NP_001038065.1; NM_001044600.1.
DR   UniGene; Ssc.49517; -.
DR   ProteinModelPortal; Q3S853; -.
DR   SMR; Q3S853; 70-202.
DR   STRING; Q3S853; -.
DR   Ensembl; ENSSSCT00000011822; ENSSSCP00000011519; ENSSSCG00000010806.
DR   GeneID; 733670; -.
DR   KEGG; ssc:733670; -.
DR   CTD; 5997; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   OMA; AKKIYTD; -.
DR   OrthoDB; EOG4ZGPD8; -.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; PIG10_2.PE7; -.
KW   ENSSSCG00000010806820036002503210000011;
KW   RGS2_PIG; DQ150111; DQ285660;
KW   Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Membrane;
KW   Nucleus; Phosphoprotein; Signal transduction inhibitor;
KW   Translation regulation.
SQ   SEQUENCE   212 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQSAMFLTVH HDCGPMDKSA GTGPKSEEKR EKMKRTLLKD WKTRLSYFLQ NSSSPGKPKT
     GKKSKPQTFI KPSPEEAQLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
     KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL
     MENNSYPRFL ESEFYQDLCR KPPQITTEPH AT
//

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