(data stored in ACNUC7421 zone)

HOGENOM: POLSQ_1_PE1007

ID   POLSQ_1_PE1007                       STANDARD;      PRT;   621 AA.
AC   POLSQ_1_PE1007; A4SXL5;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=ATP-dependent zinc metalloprotease FtsH; EC=3.4.24 -;
DE   (POLSQ_1.PE1007).
GN   Name=ftsH; OrderedLocusNames=Pnuc_1013;
OS   POLYNUCLEOBACTER NECESSARIUS SUBSP. ASYMBIOTICUS QLW-P1DMWA-1.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Polynucleobacter.
OX   NCBI_TaxID=312153;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS POLSQ_1.PE1007.
CC       Polynucleobacter necessarius subsp. asymbioticus QLW-P1DMWA-1, complete
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:A4SXL5_POLSQ
CC   -!- FUNCTION: Acts as a processive, ATP-dependent zinc
CC       metallopeptidase for both cytoplasmic and membrane proteins. Plays
CC       a role in the quality control of integral membrane proteins (By
CC       similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Homohexamer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein; Cytoplasmic side (By similarity).
CC   -!- SIMILARITY: In the C-terminal section; belongs to the peptidase
CC       M41 family.
CC   -!- SIMILARITY: In the central section; belongs to the AAA ATPase
CC       family.
CC   -!- GENE_FAMILY: HOG000217276 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A4SXL5; -.
DR   EMBL; CP000655; ABP34229.1; -; Genomic_DNA.
DR   RefSeq; YP_001155793.1; NC_009379.1.
DR   ProteinModelPortal; A4SXL5; -.
DR   SMR; A4SXL5; 139-393.
DR   STRING; A4SXL5; -.
DR   MEROPS; M41.001; -.
DR   GeneID; 5053415; -.
DR   GenomeReviews; CP000655_GR; Pnuc_1013.
DR   KEGG; pnu:Pnuc_1013; -.
DR   eggNOG; COG0465; -.
DR   OMA; VHARNVP; -.
DR   PhylomeDB; A4SXL5; -.
DR   ProtClustDB; CLSK896995; -.
DR   BioCyc; PSP312153:PNUC_1013-MONOMER; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0016887; F:ATPase activity; IEA:HAMAP.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0030163; P:protein catabolic process; IEA:HAMAP.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   HAMAP; MF_01458; FtsH; 1; -.
DR   InterPro; IPR003593; ATPase_AAA+_core.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR003960; ATPase_AAA_CS.
DR   InterPro; IPR005936; Pept_M41_FtsH.
DR   InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR   InterPro; IPR000642; Peptidase_M41.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF06480; FtsH_ext; 1.
DR   Pfam; PF01434; Peptidase_M41; 1.
DR   SMART; SM00382; AAA; 1.
DR   TIGRFAMs; TIGR01241; FtsH_fam; 1.
DR   PROSITE; PS00674; AAA; 1.
DR   HOGENOMDNA; POLSQ_1.PE1007; -.
KW   ATP-dependent metalloprotease FtsH;
KW   ATP-binding; Cell inner membrane; Cell membrane; Complete proteome;
KW   Hydrolase; Membrane; Metal-binding; Metalloprotease;
KW   Nucleotide-binding; Protease; Transmembrane; Transmembrane helix;
KW   Zinc.
SQ   SEQUENCE   621 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFQKIGVWLI VGLVLFTVFK QFDKPKDQNQ VTYSQFMDDA KAGKVKRVDV QGRTLQVTPA
     DGNKYSIISP GDIRMVGDLM KYGVQVTGKA DDEPNMLVSA LYYLGPTLLI IGFWFFMMRQ
     MQGGGKGGAF SFGKSKARLI DENSNTVTFA DVAGCDEAKE EVFELVDFLK DPQKFQKLGG
     RIPHGVLLVG PPGTGKTLLA KAIAGEAKVP FFSISGSDFV EMFVGVGASR VRDMFENAKK
     NSPCIIFIDE IDAVGRHRGA GMGGGNDERE QTLNQMLVEM DGFESNSGVI VVAATNRSDV
     LDKALLRPGR FDRQVHVGLP DIRGREQILQ VHMRKVPIDP DVNAAVLARG TPGFSGADLA
     NLVNESALFA ARRNKRSVDM KDFEDAKDKI YMGPERKSAV MREEERRNTA YHESGHAVVA
     KVLPKADPVH KVTIMPRGMA LGVTWQLPEF DRVNLYKDRM LEELAILFGG RAAEEVFLHS
     MSTGASNDFE RATKMARDMV TRYGMSDSLG TMVYVDTESE SIFGRTNSKT VSELTQQKVD
     AEIRMLIDSQ YALARSILEQ NRDKVEAMVA ALLEWETIDA EQINDIMEGR PPRTPKPPPA
     TQFGNSAGTP GPAAGSAPAT A
//

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