(data stored in ACNUC24361 zone)

HOGENOM: PONPY18_49_PE11

ID   PONPY18_49_PE11                      STANDARD;      PRT;   367 AA.
AC   PONPY18_49_PE11; Q5RAE6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Zinc finger protein 24; (PONPY18_49.PE11).
GN   Name=ZNF24;
OS   PONGO PYGMAEUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Primates; Haplorrhini; Simiiformes; Catarrhini;
OC   Hominoidea; Hominidae; Ponginae; Pongo.
OX   NCBI_TaxID=9600;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PONPY18_49.PE11.
CC       Pongo pygmaeus chromosome 18 PPYG2 partial sequence 46868756..47868755
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ZNF24_PONAB
CC   -!- FUNCTION: Transcription factor required for myelination of
CC       differentiated oligodendrocytes. Required for the conversion of
CC       oligodendrocytes from the premyelinating to the myelinating state.
CC       In the developing central nervous system (CNS), involved in the
CC       maintenance in the progenitor stage by promoting the cell cycle.
CC       Specifically bind to the 5'-TCAT-3' DNA sequence. Has
CC       transcription repressor activity in vitro (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity).
CC   -!- PTM: Sumoylated (By similarity).
CC   -!- PTM: Phosphorylated upon DNA damage, probably by ATM or ATR (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 4 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Pongo_pygmaeus;ENSPPYG00000009106;ENSPPYT00000010631;ENSPPYP00000010226.
DR   EMBL; CR859071; - ;
DR   EMBL; DQ977575; - ;
DR   UniProtKB/Swiss-Prot; Q5RAE6; -.
DR   EMBL; CR859071; CAH91264.1; -; mRNA.
DR   RefSeq; NP_001125749.1; NM_001132277.1.
DR   UniGene; Pab.591; -.
DR   HSSP; P17028; 1X6E.
DR   ProteinModelPortal; Q5RAE6; -.
DR   SMR; Q5RAE6; 45-137, 249-361.
DR   Ensembl; ENSPPYT00000010631; ENSPPYP00000010226; ENSPPYG00000009106.
DR   GeneID; 100172674; -.
DR   KEGG; pon:100172674; -.
DR   CTD; 7572; -.
DR   InParanoid; Q5RAE6; -.
DR   OrthoDB; EOG4001JC; -.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0042552; P:myelination; ISS:UniProtKB.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 4.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
DR   HOGENOMDNA; PONPY18_49.PE11; -.
KW   ENSPPYG00000009106820036002503210000011;
KW   A2T807_PONPY; Q5RAE6_PONPY; CR859071; DQ977575;
KW   DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Repeat;
KW   Repressor; Transcription; Transcription regulation; Ubl conjugation;
KW   Zinc; Zinc-finger.
SQ   SEQUENCE   367 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSAQSVEEDS ILIIPTPDEE EKILRVKLEE DPDGEEGSSI PWNHLPDPEI FRQRFRQFGY
     QDSPGPREAV SQLRELCRLW LRPETHTKEQ ILELVVLEQF VILPKELQTW VRDHHPENGE
     EAVTVLEDLE SELDDPGQPV SLRRRKREVL VEDMVSQEEA QGLPSSELDA VENQLKWASW
     ELHSLRHCDD DGRTENGALA PKQELPSAVE SHEVPGTLNM GVPQIFKYGE TCFPKGRFER
     KRNPSRKKQH ICDECGKHFS QGSALILHQR IHSGEKPYGC VECGKAFSRS SILVQHQRVH
     TGEKPYKCLE CGKAFSQNSG LINHQRIHTG EKPYECVQCG KSYSQSSNLF RHQRRHNAEK
     LLNVVKV
//

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