(data stored in ACNUC6774 zone)

HOGENOM: PROAS_1_PE1015

ID   PROAS_1_PE1015                       STANDARD;      PRT;   332 AA.
AC   PROAS_1_PE1015; D4HDE3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=3-oxoacyl-[acyl-carrier-protein] synthase 3; EC=2.3.1
DE   180;AltName: Full=3-oxoacyl-[acyl-carrier-protein] synthase III;AltName:
DE   Full=Beta-ketoacyl-ACP synthase III; (PROAS_1.PE1015).
GN   Name=fabH; OrderedLocusNames=HMPREF0675_4043;
OS   PROPIONIBACTERIUM ACNES SK137.
OC   Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales;
OC   Propionibacterineae; Propionibacteriaceae; Propionibacterium.
OX   NCBI_TaxID=553199;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PROAS_1.PE1015.
CC       Propionibacterium acnes SK137 chromosome, complete genome.
CC       annotated by Ensembl Genomes
CC   -!- ANNOTATIONS ORIGIN:D4HDE3_PROAS
CC   -!- FUNCTION: Catalyzes the condensation reaction of fatty acid
CC       synthesis by the addition to an acyl acceptor of two carbons from
CC       malonyl-ACP. Catalyzes the first condensation reaction which
CC       initiates fatty acid synthesis and may therefore play a role in
CC       governing the total rate of fatty acid production. Possesses both
CC       acetoacetyl-ACP synthase and acetyl transacylase activities. Its
CC       substrate specificity determines the biosynthesis of branched-
CC       chain and/or straight-chain of fatty acids (By similarity).
CC   -!- CATALYTIC ACTIVITY: Acetyl-CoA + malonyl-[acyl-carrier-protein] =
CC       acetoacetyl-[acyl-carrier-protein] + CoA + CO(2).
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- DOMAIN: The last Arg residue of the ACP-binding site is essential
CC       for the weak association between ACP/AcpP and FabH (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the fabH family.
CC   -!- GENE_FAMILY: HOG000246674 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; D4HDE3; -.
DR   EMBL; CP001977; ADE01158.1; -; Genomic_DNA.
DR   RefSeq; YP_003581207.1; NC_014039.1.
DR   ProteinModelPortal; D4HDE3; -.
DR   GeneID; 9075211; -.
DR   GenomeReviews; CP001977_GR; HMPREF0675_4043.
DR   KEGG; pak:HMPREF0675_4043; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:HAMAP.
DR   GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:EC.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_01815; FabH; 1; -.
DR   InterPro; IPR013751; ACP_syn_III.
DR   InterPro; IPR013747; ACP_syn_III_C.
DR   InterPro; IPR004655; FabH_synth.
DR   InterPro; IPR016039; Thiolase-like.
DR   InterPro; IPR016038; Thiolase-like_subgr.
DR   Gene3D; G3DSA:3.40.47.10; Thiolase-like_subgr; 2.
DR   Pfam; PF08545; ACP_syn_III; 1.
DR   Pfam; PF08541; ACP_syn_III_C; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   TIGRFAMs; TIGR00747; FabH; 1.
DR   HOGENOMDNA; PROAS_1.PE1015; -.
KW   Acyltransferase; Complete proteome; Cytoplasm;
KW   Fatty acid biosynthesis; Lipid synthesis; Multifunctional enzyme;
KW   Transferase.
SQ   SEQUENCE   332 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTAIKTRPVH GYSKFLSTGS ARGSRVVTNK EMCTLIDSTP EWIEQRTGIT ERRWATNSET
     VASMGTTAAR TALERSGLEA SQIDAIIVAT VSHHRPSPSL AAYIARELGL GDAAAFDLNG
     ACAGFCYSTA LADSMIRTGS ANYVLVIGVE KLSEMTNLDD RSTAFLFSDG AGAAIIGASD
     EPGIGPVVWG SRSDQLKTIE LEDWPTASAD PNKIHPLIRM EGRAVFKWAM TDVAKRAAEA
     IAEAGITPAD LDVFIPHQAN DRITDVVSRH LKLPESVTVC HDIADMGNTS AASVPIAIDR
     MLQRGQAHSG DLALIIGFGA GLVYAGQVIR LP
//

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