(data stored in ACNUC7421 zone)

HOGENOM: PROM5_1_PE1013

ID   PROM5_1_PE1013                       STANDARD;      PRT;   312 AA.
AC   PROM5_1_PE1013; A2BWR1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=4-diphosphocytidyl-2-C-methyl-D-erythritol kinase;
DE   Short=CMK; EC=2.7.1 148;AltName:
DE   Full=4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase;
DE   (PROM5_1.PE1013).
GN   Name=ispE; OrderedLocusNames=P9515_10151;
OS   PROCHLOROCOCCUS MARINUS STR. MIT 9515.
OC   Bacteria; Cyanobacteria; Prochlorales; Prochlorococcaceae;
OC   Prochlorococcus.
OX   NCBI_TaxID=167542;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PROM5_1.PE1013.
CC       Prochlorococcus marinus str. MIT 9515, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:ISPE_PROM5
CC   -!- FUNCTION: Catalyzes the phosphorylation of the position 2 hydroxy
CC       group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: ATP + 4-(cytidine 5'-diphospho)-2-C-methyl-D-
CC       erythritol = ADP + 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-
CC       D-erythritol.
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate
CC       biosynthesis via DXP pathway; isopentenyl diphosphate from 1-
CC       deoxy-D-xylulose 5-phosphate: step 3/6.
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. IspE subfamily.
CC   -!- GENE_FAMILY: HOG000019600 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; A2BWR1; -.
DR   EMBL; CP000552; ABM72222.1; -; Genomic_DNA.
DR   RefSeq; YP_001011329.1; NC_008817.1.
DR   ProteinModelPortal; A2BWR1; -.
DR   STRING; A2BWR1; -.
DR   GeneID; 4719163; -.
DR   GenomeReviews; CP000552_GR; P9515_10151.
DR   KEGG; pmc:P9515_10151; -.
DR   eggNOG; COG1947; -.
DR   OMA; QLCFGRG; -.
DR   ProtClustDB; PRK02534; -.
DR   GO; GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
DR   HAMAP; MF_00061; IspE; 1; -.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR004424; IspE.
DR   InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR   InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   PANTHER; PTHR20861:SF2; IspE; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF010376; IspE; 1.
DR   SUPFAM; SSF54211; Ribosomal_S5_D2-typ_fold; 1.
DR   TIGRFAMs; TIGR00154; IspE; 1.
DR   HOGENOMDNA; PROM5_1.PE1013; -.
KW   ATP-binding; Complete proteome; Isoprene biosynthesis; Kinase;
KW   Nucleotide-binding; Transferase.
SQ   SEQUENCE   312 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTKLSTTKIC VKSPAKINLH LEIIGKREDG YHELAMIMQN IDLFDYIEFE NNQIGDIELK
     SNNKDLSLKD DNLIIKAANY VKDISKKKDL GANIFLKKNI PIGAGLAGGS SNAAATIIGL
     NKLWDLDLDN ETMLSLSSKL GSDVPFFING GCQFCFGRGE ILENYNSKFD YGVILLKNPN
     ISISTADTYK KYSKEYCSNF LTESEKTNDI RNDLRINGFN DLNSSNQIIK VKNDLQIIVE
     KENDSVKKAL YLLSNLQNCL SFSMSGSGPT CFALFKDINK ANEVFEQNHK MFNNNGFEAW
     VCKLINSGIT FL
//

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