(data stored in ACNUC7421 zone)

HOGENOM: PROMH_1_PE101

ID   PROMH_1_PE101                        STANDARD;      PRT;   294 AA.
AC   PROMH_1_PE101; B4EU42;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protoheme IX farnesyltransferase; EC=2.5.1 -;AltName:
DE   Full=Heme B farnesyltransferase;AltName: Full=Heme O synthase;
DE   (PROMH_1.PE101).
GN   Name=cyoE; OrderedLocusNames=PMI0105;
OS   PROTEUS MIRABILIS HI4320.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales;
OC   Enterobacteriaceae; Proteus.
OX   NCBI_TaxID=529507;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PROMH_1.PE101.
CC       Proteus mirabilis HI4320 chromosome, complete genome.
CC       genome.
CC   -!- ANNOTATIONS ORIGIN:B4EU42_PROMH
CC   -!- FUNCTION: Converts heme B (protoheme IX) to heme O by substitution
CC       of the vinyl group on carbon 2 of heme B porphyrin ring with a
CC       hydroxyethyl farnesyl side group (By similarity).
CC   -!- PATHWAY: Porphyrin metabolism; heme O biosynthesis; heme O from
CC       protoheme: step 1/1.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- MISCELLANEOUS: Carbon 2 of the heme B porphyrin ring is defined
CC       according to the Fischer nomenclature (By similarity).
CC   -!- SIMILARITY: Belongs to the UbiA prenyltransferase family.
CC       Protoheme IX farnesyltransferase subfamily.
CC   -!- GENE_FAMILY: HOG000237290 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; B4EU42; -.
DR   EMBL; AM942759; CAR40374.1; -; Genomic_DNA.
DR   RefSeq; YP_002149888.1; NC_010554.1.
DR   STRING; B4EU42; -.
DR   GeneID; 6802660; -.
DR   GenomeReviews; AM942759_GR; PMI0105.
DR   OMA; VGYCAVT; -.
DR   ProtClustDB; PRK04375; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008495; F:protoheme IX farnesyltransferase activity; IEA:HAMAP.
DR   GO; GO:0048034; P:heme O biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00154; CyoE_CtaB; 1; -.
DR   InterPro; IPR006369; Protohaem_IX_farnesylTrfase.
DR   InterPro; IPR000537; UbiA_prenyltransferase.
DR   Pfam; PF01040; UbiA; 1.
DR   TIGRFAMs; TIGR01473; CyoE_ctaB; 1.
DR   PROSITE; PS00943; UBIA; 1.
DR   HOGENOMDNA; PROMH_1.PE101; -.
KW   Cell inner membrane; Cell membrane; Complete proteome;
KW   Heme biosynthesis; Membrane; Transferase; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   294 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MIKQYLQVTK PGIIFGNLIS VIGGFLLASK GEIDYPLFFA TLLGVSLVVA SGCVFNNYID
     RDIDRIMERT KNRPLVQGLI DPQISLIYAS VLGIAGVVLL YVAANPLAMF IAVFGFIIYV
     GVYSLYMKRK SVYGTLIGSL SGSAPPVIGY CAVSGEFDAG AAILLLIFSL WQMPHSYAIA
     IFRFKDYQAA NIPVLPVIKG ISVAKRHIIL YILAFMVATL MLTLVGYAGY KYLIVASAVS
     IWWLGMALSG YKATNDKVWA RKLFIFSIIA ITSLSVMMSV DPTSSTETVL AYLR
//

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