(data stored in ACNUC7421 zone)

HOGENOM: PSEF5_1_PE1013

ID   PSEF5_1_PE1013                       STANDARD;      PRT;   199 AA.
AC   PSEF5_1_PE1013; Q4KHW8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=GTP cyclohydrolase-2 1; EC=3.5.4 25;AltName: Full=GTP
DE   cyclohydrolase II 1; (PSEF5_1.PE1013).
GN   Name=ribA; Synonyms=ribA1; OrderedLocusNames=PFL_1034;
OS   PSEUDOMONAS FLUORESCENS PF-5.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=220664;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS PSEF5_1.PE1013.
CC       Pseudomonas fluorescens Pf-5, complete genome.
CC       sequence.
CC   -!- ANNOTATIONS ORIGIN:Q4KHW8_PSEF5
CC   -!- FUNCTION: Catalyzes the conversion of GTP to 2,5-diamino-6-
CC       ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and
CC       pyrophosphate (By similarity).
CC   -!- CATALYTIC ACTIVITY: GTP + 3 H(2)O = formate + 2,5-diamino-6-
CC       hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + diphosphate.
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-
CC       6-(D-ribitylamino)uracil from GTP: step 1/4.
CC   -!- SIMILARITY: Belongs to the GTP cyclohydrolase II family.
CC   -!- GENE_FAMILY: HOG000115442 [ FAMILY / ALN / TREE ]
DR   UniProtKB/Swiss-Prot; Q4KHW8; -.
DR   EMBL; CP000076; AAY90321.1; -; Genomic_DNA.
DR   RefSeq; YP_258165.1; NC_004129.6.
DR   ProteinModelPortal; Q4KHW8; -.
DR   STRING; Q4KHW8; -.
DR   GeneID; 3477523; -.
DR   GenomeReviews; CP000076_GR; PFL_1034.
DR   KEGG; pfl:PFL_1034; -.
DR   NMPDR; fig|220664.3.peg.2478; -.
DR   eggNOG; COG0807; -.
DR   OMA; TDKEHVA; -.
DR   PhylomeDB; Q4KHW8; -.
DR   ProtClustDB; PRK00393; -.
DR   BioCyc; PFLU220664:PFL_1034-MONOMER; -.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003935; F:GTP cyclohydrolase II activity; IEA:HAMAP.
DR   GO; GO:0008270; F:zinc ion binding; IEA:HAMAP.
DR   GO; GO:0009231; P:riboflavin biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00179; RibA; 1; -.
DR   InterPro; IPR000926; GTP_CycHdrlaseII_RibA.
DR   Pfam; PF00925; GTP_cyclohydro2; 1.
DR   HOGENOMDNA; PSEF5_1.PE1013; -.
KW   Complete proteome; GTP-binding; Hydrolase; Metal-binding;
KW   Nucleotide-binding; Riboflavin biosynthesis; Zinc.
SQ   SEQUENCE   199 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MNTLSIRNQV DIPLNDSPTP GTFYSFSGLE AAHEHILIKL GPASEHSPLV RIHSECLTGD
     VFNSQRCDCG PQLSESISRM QEEGGYLIYL RQEGRGIGLY AKLDAYRLQD GGMDTFEANS
     HLNFPEDGRD FSMAARMLKA LGVQHCRLIT NNPDKVQALK DNGIIVDSTI PTGVFLTRHN
     SHYLQAKKDK KHHLIDLIK
//

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