(data stored in ACNUC1130 zone)

HOVERGEN: Q08757_CHICK

ID   Q08757_CHICK            Unreviewed;      1404 AA.
AC   Q08757;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   03-NOV-2009, entry version 67.
DE   SubName: Full=C-sea protein;
DE   Flags: Precursor;
GN   Name=c-sea;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=93317639; PubMed=8392188; DOI=10.1073/pnas.90.13.6140;
RA   Huff J.L., Jelinek M.A., Borgman C.A., Lansing T.J., Parsons J.T.;
RT   "The protooncogene c-sea encodes a transmembrane protein-tyrosine
RT   kinase related to the Met/hepatocyte growth factor/scatter factor
RT   receptor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:6140-6144(1993).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; L12024; AAA48729.1; -; Genomic_DNA.
DR   IPI; IPI00596153; -.
DR   PIR; A48196; A48196.
DR   RefSeq; NP_001026634.1; -.
DR   UniGene; Gga.29675; -.
DR   HSSP; P08581; 1R1W.
DR   GeneID; 427573; -.
DR   KEGG; gga:427573; -.
DR   CTD; 427573; -.
DR   HOVERGEN; Q08757; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR016201; Plexin-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR008266; Tyr_prot_kinase_AS.
DR   InterPro; IPR001245; Tyr_prot_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_prot_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR020706; Tyr_prot_kinase_rcpt_SEA.
DR   InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom.
DR   PANTHER; PTHR23256:SF165; Tyr_prot_kinase_rcpt_SEA; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 3.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   3: Inferred from homology;
DR   PRODOM; Q08757.
DR   SWISS-2DPAGE; Q08757.
KW   ATP-binding; Membrane; Nucleotide-binding; Signal; Transmembrane;
KW   Tyrosine-protein kinase.
FT   DOMAIN       52    143       PRODOM:2005.1:PD003973  45
FT   DOMAIN      145    223       PRODOM:2005.1:PD962738  14
FT   DOMAIN      225    390       PRODOM:2005.1:PD331587  41
FT   DOMAIN      391    470       PRODOM:2005.1:PD314756  3
FT   DOMAIN      471    525       PRODOM:2005.1:PDA1E5D5  5
FT   DOMAIN      526    657       PRODOM:2005.1:PD001668  42
FT   DOMAIN      683    747       PRODOM:2005.1:PD951554  15
FT   DOMAIN      753    959       PRODOM:2005.1:PD591320  41
FT   DOMAIN      960   1029       PRODOM:2005.1:PD447314  1
FT   DOMAIN     1030   1093       PRODOM:2005.1:PD026314  2
FT   DOMAIN     1093   1341       PRODOM:2005.1:PD000001  8496
FT   DOMAIN     1343   1387       PRODOM:2005.1:PD476139  2
FT   SIGNAL        1     22       Potential.
FT   CHAIN        23   1404       Potential.
FT                                /FTId=PRO_5000142160.
SQ   SEQUENCE   1404 AA;  153851 MW;  D0BC9EC193E27848 CRC64;
     MGPRCLVCLL LLLAPSLLQA GAWQCRRIPF SSTRNFSVPY TLPSLDAGSP VQNIAVFPDP
     PTVFVAVRNR ILVVDPELRL RSVLVTGPTG SAPCEICRLC PAAVDAPGPE DVDNVLLLLD
     PVEPWLYSCG TARRGLCYLH QLDVRGSEVT IASTRCLYSA AANSPVNCPD CVASPLGSTA
     TVVADRYTAS FYLGSTVNSS VAARYSPRSV SVRRLKGTRD GFADPFHSLT VLPHYQDVYP
     IHYVHSFTDG DHVYLVTVQP EFPGSSTFHT RLVRLSAHEP ELRRYREIVL DCRYESKRRR
     RRRGAEEETE RDVAYNVLQA AHAARPGARL ARDLGIDGTE TVLFGAFAES HPESRAPQHN
     SAVCAFPLRL LNQAIREGMD KCCGTGTQTL KRGLAFFQPQ QYCPHSVNLS APVTNTSCWD
     QPTLVPAASH KVDLFNGRLS GTLLTSIFVT VLQNVTVAHL GTAQGRVLQM VLQRSSSYVV
     ALTNFSLGEP GLVQHATGLQ GHSLLFAAGT KVWRVNVTGP GCRHFSTCDR CLRAERFMGC
     GWCGNGCTRH HECAGPWVQD SCPPVLTDFH PRSAPLRGQT RVTLCGMTFH SPPDPTAHHS
     LPGPYRVAVG GRSCTVLLDE SESYRPLPTF RRKDFVDVLV CVLEPGEPAV AAGPADVVLN
     VTESAGTSRF RVQGSSTLSG FVFVEPHIST LHPSFGPQGG GTLMSLYGTH LSAGSSWRVT
     INGSECLLDG QPSEGDGEIR CTAPAATSLG AAPVALWIDG EEFLAPLPFE YRPDPSVLTV
     VPNCSYGGST LTLIGTHLDS VYRAKIQFQG GGGGKTEATE CEGPQSPNWL LCRSPAFPIE
     IKPVPGNLSV LLDGAADRWL FRLRYFPQPQ MFSFGQQGER YQLKPGDNEI KVNQLGLDSV
     AGCMNITMTV GGRDCHPNVL KNEVTCRVPR DVDLTPAGAP VQICVNGDCQ ALGLVLPASS
     LDMAASLALG TGVTFLVCCV LAAVLLRWRW RKRRGLENLE LLVHPPRIEH PITIQRPNVD
     YREVQVLPVA DSPGLARPHA HFASAGADAA GGGSPVPLLR TTSCCLEDLR PELLEEVKDI
     LIPEERLITH RSRVIGRGHF GSVYHGTYMD PLLGNLHCAV KSLHRITDLE EVEEFLREGI
     LMKSFHHPQV LSLLGVCLPR HGLPLVVLPY MRHGDLRHFI RAQERSPTVK ELIGFGLQVA
     LGMEYLAQKK FVHRDLAARN CMLDETLTVK VADFGLARDV FGKEYYSIRQ HRHAKLPVKW
     MALESLQTQK FTTKSDVWSF GVLMWELLTR GASPYPEVDP YDMARYLLRG RRLPQPQPCP
     DTLYGVMLSC WAPTPEERPS FSGLVCELER VLASLEGERY VNLAVTYVNL ESGPPFPPAP
     RGQLPDSEDE EDEEDEEDED AAVR
//

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