(data stored in ACNUC1130 zone)

HOVERGEN: Q2IBC7_RAT

ID   Q2IBC7_RAT              Unreviewed;      1382 AA.
AC   Q2IBC7;
DT   07-MAR-2006, integrated into UniProtKB/TrEMBL.
DT   07-MAR-2006, sequence version 1.
DT   03-NOV-2009, entry version 38.
DE   SubName: Full=Met proto-oncogene;
GN   Name=LOC500040; Synonyms=Capza2, Cav, Cav2, Cftr, Met, ST7, Wnt2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN;
RX   MEDLINE=22799194; PubMed=12917688; DOI=10.1038/nature01858;
RA   Thomas J.W., Touchman J.W., Blakesley R.W., Bouffard G.G.,
RA   Beckstrom-Sternberg S.M., Margulies E.H., Blanchette M., Siepel A.C.,
RA   Thomas P.J., McDowell J.C., Maskeri B., Hansen N.F., Schwartz M.S.,
RA   Weber R.J., Kent W.J., Karolchik D., Bruen T.C., Bevan R.,
RA   Cutler D.J., Schwartz S., Elnitski L., Idol J.R., Prasad A.B.,
RA   Lee-Lin S.-Q., Maduro V.V.B., Summers T.J., Portnoy M.E.,
RA   Dietrich N.L., Akhter N., Ayele K., Benjamin B., Cariaga K.,
RA   Brinkley C.P., Brooks S.Y., Granite S., Guan X., Gupta J.,
RA   Haghighi P., Ho S.-L., Huang M.C., Karlins E., Laric P.L., Legaspi R.,
RA   Lim M.J., Maduro Q.L., Masiello C.A., Mastrian S.D., McCloskey J.C.,
RA   Pearson R., Stantripop S., Tiongson E.E., Tran J.T., Tsurgeon C.,
RA   Vogt J.L., Walker M.A., Wetherby K.D., Wiggins L.S., Young A.C.,
RA   Zhang L.-H., Osoegawa K., Zhu B., Zhao B., Shu C.L., De Jong P.J.,
RA   Lawrence C.E., Smit A.F., Chakravarti A., Haussler D., Green P.,
RA   Miller W., Green E.D.;
RT   "Comparative analyses of multi-species sequences from targeted genomic
RT   regions.";
RL   Nature 424:788-793(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BN;
RA   Green E.D.;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; DP000027; AAR16309.1; -; Genomic_DNA.
DR   IPI; IPI00734796; -.
DR   UniGene; Rn.10617; -.
DR   SMR; Q2IBC7; 40-565, 1047-1347.
DR   STRING; Q2IBC7; -.
DR   Ensembl; ENSRNOT00000009662; ENSRNOP00000009662; ENSRNOG00000007079; Rattus norvegicus.
DR   NMPDR; fig|10116.3.peg.20876; -.
DR   HOVERGEN; Q2IBC7; -.
DR   OMA; FIGEHYV; -.
DR   ArrayExpress; Q2IBC7; -.
DR   Genevestigator; Q2IBC7; -.
DR   GO; GO:0019861; C:flagellum; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; NAS:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IDA:RGD.
DR   GO; GO:0004872; F:receptor activity; IEA:InterPro.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0007595; P:lactation; IEP:RGD.
DR   GO; GO:0001764; P:neuron migration; IDA:RGD.
DR   GO; GO:0046777; P:protein amino acid autophosphorylation; IDA:RGD.
DR   GO; GO:0030317; P:sperm motility; IMP:RGD.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR016201; Plexin-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR020707; Tyr_kinase_hepatocyte_GF_rcpt.
DR   InterPro; IPR008266; Tyr_prot_kinase_AS.
DR   InterPro; IPR001245; Tyr_prot_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_prot_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   PANTHER; PTHR23256:SF169; Tyr_kinase_hepatocyte_GF_rcpt; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q2IBC7.
DR   SWISS-2DPAGE; Q2IBC7.
KW   ATP-binding; Membrane; Nucleotide-binding; Transmembrane;
KW   Tyrosine-protein kinase.
SQ   SEQUENCE   1382 AA;  153963 MW;  8A240A081579D9A2 CRC64;
     MKAPTALAPG ILLLLLTLAQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIHNVVLHGH
     HIYLGATNYI YVLDDKDLQK VSEFKTGPVV EHPDCFPCQD CSSKANVSGG VWKDNVNMAL
     LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN AADIQSEVHC MFSPLAEEES GQCPDCVVSA
     LGAKVLLSEK DRFINFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP
     EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI
     LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPYD DILYGVFAQS KPDSAEPMNR
     SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE
     FTTALQRVDL FMGRLNHVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TAHFTPHVNF
     LLDSYPVSPE VIVEHPSNQN GYTLVVTGKK ITKIPLNGLG CGHFQSCSQC LSAPYFIQCG
     WCHNRCVHSN ECPSGTWTQE ICLPAVYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR
     KTKVLLGNES CTLTLSESTT NTLKCTVGPA MSEHFNVSVI VSNSRETTQY SAFSYVDPVI
     TSISPRYGPH AGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPGHTVSAE
     FPVKLKIDLA DRVTSSFSYR EDPVVSEIHP TKSFISGGST ITGIGKNLNS VSTPKLVIEV
     HDVGVNYTVA CQHRSSSEII CCTTPSLQQL DLQLPLKTKA FFLLDGILSK HFDLTYVHDP
     MFKPFEKPVM ISMGNENVVE IKGDDIDPEA VKGEVLKVGN KSCENLHWHS EALLCTVPSD
     LLKLNGGELN IEWKQAVSST VLGKVIVQPD QNFAGLIIGA VSISVVVLLV SGLFLWLRKR
     KHKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG
     ACRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH
     FNEVIGRGHF GCVYHGTLLD SDGKKIHCAV KSLNRITDIE EVSQFLTEGI IMKDFSHPNV
     LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
     FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK
     FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG RRLLQPEYCP DALYEVMLKC
     WHPKAEMRPS FSELVSRISS IFSTFIGEHY VHVNATYVNV KCVAPYPSLL PSQDNIDGEA
     NT
//

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