(data stored in ACNUC6163 zone)

HOVERGEN: Q32M36_HUMAN

ID   Q32M36_HUMAN            Unreviewed;      1146 AA.
AC   Q32M36;
DT   06-DEC-2005, integrated into UniProtKB/TrEMBL.
DT   06-DEC-2005, sequence version 1.
DT   03-NOV-2009, entry version 39.
DE   SubName: Full=ATP8A1 protein;
GN   Name=ATP8A1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP +
CC       phosphate + phospholipid(Out).
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CC   -!- GENE_FAMILY: HBG050601 [ FAMILY / ALN / TREE ]
DR   EMBL; BC109317; AAI09318.1; -; mRNA.
DR   IPI; IPI00221038; -.
DR   RefSeq; NP_001098999.1; -.
DR   UniGene; Hs.435052; -.
DR   Ensembl; ENST00000264449; ENSP00000264449; ENSG00000124406; Homo sapiens.
DR   Ensembl; ENST00000381662; ENSP00000371078; ENSG00000124406; Homo sapiens.
DR   Ensembl; ENST00000381668; ENSP00000371084; ENSG00000124406; Homo sapiens.
DR   GeneID; 10396; -.
DR   KEGG; hsa:10396; -.
DR   UCSC; uc003gws.2; human.
DR   CTD; 10396; -.
DR   HGNC; HGNC:13531; ATP8A1.
DR   HOVERGEN; Q32M36; -.
DR   NextBio; 39390; -.
DR   ArrayExpress; Q32M36; -.
DR   Bgee; Q32M36; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004012; F:phospholipid-translocating ATPase activity; IEA:InterPro.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   InterPro; IPR008250; ATPase_P-typ_ATPase-assoc-reg.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006539; ATPase_P-typ_Plipid-transl.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   PANTHER; PTHR11939; ATPase_P; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 4.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q32M36.
DR   SWISS-2DPAGE; Q32M36.
KW   ATP-binding; Hydrolase; Magnesium; Membrane; Nucleotide-binding;
KW   Transmembrane.
SQ   SEQUENCE   1146 AA;  129393 MW;  33D99160EBB9DCEE CRC64;
     MRRTVSEIRS RAEGYEKTDD VSEKTSLADQ EEVRTIFINQ PQLTKFCNNH VSTAKYNIIT
     FLPRFLYSQF RRAANSFFLF IALLQQIPDV SPTGRYTTLV PLLFILAVAA IKEIIEDIKR
     HKADNAVNKK QTQVLRNGAW EIVHWEKVNV GDIVIIKGKE YIPADTVLLS SSEPQAMCYI
     ETSNLDGETN LKIRQGLPAT SDIKDVDSLM RISGRIECES PNRHLYDFVG NIRLDGHGTV
     PLGADQILLR GAQLRNTQWV HGIVVYTGHD TKLMQNSTSP PLKLSNVERI TNVQILILFC
     ILIAMSLVCS VGSAIWNRRH SGKDWYLNLN YGGASNFGLN FLTFIILFNN LIPISLLVTL
     EVVKFTQAYF INWDLDMHYE PTDTAAMART SNLNEELGQV KYIFSDKTGT LTCNVMQFKK
     CTIAGVAYGQ NSQFGDEKTF SDSSLLENLQ NNHPTAPIIC EFLTMMAVCH TAVPEREGDK
     IIYQAASPDE GALVRAAKQL NFVFTGRTPD SVIIDSLGQE ERYELLNVLE FTSARKRMSV
     IVRTPSGKLR LYCKGADTVI YDRLAETSKY KEITLKHLEQ FATEGLRTLC FAVAEISESD
     FQEWRAVYQR ASTSVQNRLL KLEESYELIE KNLQLLGATA IEDKLQDQVP ETIETLMKAD
     IKIWILTGDK QETAINIGHS CKLLKKNMGM IVINEGSLDG TRETLSRHCT TLGDALRKEN
     DFALIIDGKT LKYALTFGVR QYFLDLALSC KAVICCRVSP LQKSEVVEMV KKQVKVVTLA
     IGDGANDVSM IQTAHVGVGI SGNEGLQAAN SSDYSIAQFK YLKNLLMIHG AWNYNRVSKC
     ILYCFYKNIV LYIIEIWFAF VNGFSGQILF ERWCIGLYNV MFTAMPPLTL GIFERSCRKE
     NMLKYPELYK TSQNALDFNT KVFWVHCLNG LFHSVILFWF PLKALQYGTA FGNGKTSDYL
     LLGNFVYTFV VITVCLKAGL ETSYWTWFSH IAIWGSIALW VVFFGIYSSL WPAIPMAPDM
     SGEAAMLFSS GVFWMGLLFI PVASLLLDVV YKVIKRTAFK TLVDEVQELE AKSQDPGAVV
     LGKSLTERAQ LLKNVFKKNH VNLYRSESLQ QNLLHGYAFS QDENGIVSQS EVIRAYDTTK
     QRPDEW
//

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