(data stored in ACNUC13530 zone)

HOVERGEN: Q499G7_HUMAN

ID   Q499G7_HUMAN            Unreviewed;       360 AA.
AC   Q499G7;
DT   13-SEP-2005, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2005, sequence version 1.
DT   03-NOV-2009, entry version 43.
DE   SubName: Full=Mitogen-activated protein kinase 1;
GN   Name=MAPK1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
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CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; BC099905; AAH99905.1; -; mRNA.
DR   IPI; IPI00003479; -.
DR   RefSeq; NP_002736.3; -.
DR   UniGene; Hs.431850; -.
DR   SMR; Q499G7; 12-356.
DR   STRING; Q499G7; -.
DR   Ensembl; ENST00000215832; ENSP00000215832; ENSG00000100030; Homo sapiens.
DR   Ensembl; ENST00000398822; ENSP00000381803; ENSG00000100030; Homo sapiens.
DR   Ensembl; ENST00000415911; ENSP00000409149; ENSG00000100030; Homo sapiens.
DR   GeneID; 5594; -.
DR   HGNC; HGNC:6871; MAPK1.
DR   HOVERGEN; Q499G7; -.
DR   ArrayExpress; Q499G7; -.
DR   Bgee; Q499G7; -.
DR   GO; GO:0005829; C:cytosol; IEA:Compara.
DR   GO; GO:0005634; C:nucleus; IEA:Compara.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016908; F:MAP kinase 2 activity; IEA:Compara.
DR   GO; GO:0001784; F:phosphotyrosine binding; IEA:Compara.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
DR   GO; GO:0019858; P:cytosine metabolic process; IEA:Compara.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
DR   GO; GO:0000165; P:MAPKKK cascade; IEA:Compara.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Compara.
DR   GO; GO:0009887; P:organ morphogenesis; IEA:Compara.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:Compara.
DR   GO; GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Compara.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Compara.
DR   InterPro; IPR008349; Erk_1_2_MAPK.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003527; MAP_kinase_CS.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_prot_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_prot_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR01770; ERK1ERK2MAPK.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS01351; MAPK; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q499G7.
DR   SWISS-2DPAGE; Q499G7.
KW   ATP-binding; Kinase; Nucleotide-binding;
KW   Serine/threonine-protein kinase.
SQ   SEQUENCE   360 AA;  41331 MW;  D4271876ABA25E32 CRC64;
     MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR VAIKKISPFE
     HQTYCQRTLR EIKILLRSRH ENIIGINDII RAPTIEQMKD VYIVQDLMET DLYKLLKTQH
     LSNDHICYFL YQILRGLKYI HSANVLHRDL KPSNLLLNTT CDLEICDFGL ARVADPDHDH
     TGFLTEYVAT RWYRAPEIML NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI
     LGILGSPSQE DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK
     RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE TARFQPGYRS
//

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