(data stored in ACNUC6163 zone)

HOVERGEN: Q59EX4_HUMAN

ID   Q59EX4_HUMAN            Unreviewed;      1177 AA.
AC   Q59EX4;
DT   26-APR-2005, integrated into UniProtKB/TrEMBL.
DT   26-APR-2005, sequence version 1.
DT   03-NOV-2009, entry version 42.
DE   SubName: Full=ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 variant;
DE   Flags: Fragment;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Brain;
RA   Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.,
RA   Ohara O., Nagase T., Kikuno R.F.;
RT   "Homo sapiens protein coding cDNA.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP +
CC       phosphate + phospholipid(Out).
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CC   -!- GENE_FAMILY: HBG050601 [ FAMILY / ALN / TREE ]
DR   EMBL; AB209687; BAD92924.1; -; mRNA.
DR   IPI; IPI00032402; -.
DR   UniGene; Hs.435052; -.
DR   Ensembl; ENST00000264449; ENSP00000264449; ENSG00000124406; Homo sapiens.
DR   Ensembl; ENST00000381662; ENSP00000371078; ENSG00000124406; Homo sapiens.
DR   Ensembl; ENST00000381668; ENSP00000371084; ENSG00000124406; Homo sapiens.
DR   HGNC; HGNC:13531; ATP8A1.
DR   HOVERGEN; Q59EX4; -.
DR   ArrayExpress; Q59EX4; -.
DR   Bgee; Q59EX4; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004012; F:phospholipid-translocating ATPase activity; IEA:InterPro.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   InterPro; IPR008250; ATPase_P-typ_ATPase-assoc-reg.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006539; ATPase_P-typ_Plipid-transl.
DR   InterPro; IPR005834; Dehalogen-like_hydro.
DR   PANTHER; PTHR11939; ATPase_P; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 4.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q59EX4.
DR   SWISS-2DPAGE; Q59EX4.
KW   ATP-binding; Hydrolase; Magnesium; Membrane; Nucleotide-binding;
KW   Transmembrane.
FT   NON_TER       1      1
SQ   SEQUENCE   1177 AA;  132772 MW;  507D0B49A1C3E459 CRC64;
     AAQPGLPRVP RRDRCRVRAE DPPAAAAAMP TMRRTVSEIR SRAEGYEKTD DVSEKTSLAD
     QEEVRTIFIN QPQLTKFCNN HVSTAKYNII TFLPRFLYSQ FRRAANSFFL FIALLQQIPD
     VSPTGRYTTL VPLLFILAVA AIKEIIEDIK RHKADNAVNK KQTQVLRNGA WEIVHWEKVN
     VGDIVIIKGK EYIPADTVLL SSSEPQAMCY IETSNLDGET NLKIRQGLPA TSDIKDVDSL
     MRISGRIECE SPNRHLYDFV GNIRLDGHGT VPLGADQILL RGAQLRNTQW VHGIVVYTGH
     DTKLMQNSTS PPLKLSNVER ITNVQILILF CILIAMSLVC SVGSAIWNRR HSGKDWYLNL
     NYGGASNFGL NFLTFIILFN NLIPISLLVT LEVVKFTQAY FINWDLDMHY EPTDTAAMAR
     TSNLNEELGQ VKYIFSDKTG TLTCNVMQFK KCTIAGVAYG QNSQFGDEKT FSDSSLLENL
     QNNHPTAPII CEFLTMMAVC HTAVPERERD KIIYQAASPD EGALVRAAKQ LNFVFTGRTP
     DSVIIDSLGQ EERYELLNVL EFTSARKRMS VIVRTPSGKL RLYCKGADTV IYDRLAETSK
     YKEITLKHLE QFATEGLRTL CFAVAEISES DFQEWRAVYQ RASTSVQNRL LKLEESYELI
     EKNLQLLGAT AIEDKLQDQV PETIETLMKA DIKIWILTGD KQETAINIGH SCKLLKKNMG
     MIVINEGSLD GTRETLSRHC TTLGDALRKE NDFALIIDGK TLKYALTFGV RQYFLDLALS
     CKAVICCRVS PLQKSEVVEM VKKQVKVVTL AIGDGANDVS MIQTAHVGVG ISGNEGLQAA
     NSSDYSIAQF KYLKNLLMIH GAWNYNRVSK CILYCFYKNI VLYIIEIWFA FVNGFSGQIL
     FERWCIGLYN VMFTAMPPLT LGIFERSCRK ENMLKYPELY KTSQNALDFN TKVFWVHCLN
     GLFHSVILFW FPLKALQYGT AFGNGKTSDY LLLGNFVYTF VVITVCLKAG LETSYWTWFS
     HIAIWGSIAL WVVFFGIYSS LWPAIPMAPD MSGEAAMLFS SGVFWMGLLF IPVASLLLDV
     VYKVIKRTAF KTLVDEVQEL EAKSQDPGAV VLGKSLTERA QLLKNVFKKN HVNLYRSESL
     QQNLLHGYAF SQDENGIVSQ SEVIRAYDTT KQRPDEW
//

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