(data stored in ACNUC4932 zone)

HOVERGEN: Q5VX18_HUMAN

ID   Q5VX18_HUMAN            Unreviewed;       520 AA.
AC   Q5VX18;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   03-NOV-2009, entry version 46.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase;
DE            EC=3.1.3.46;
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2,6-biphosphata se 3;
DE   SubName: Full=cDNA FLJ75111, highly similar to Homo sapiens 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3(PFKFB3), mRNA;
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3, isoform CRA_b;
GN   Name=PFKFB3; ORFNames=RP11-298K24.3-002, hCG_24831;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Howden P.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Wakamatsu A., Yamamoto J., Kimura K., Ishii S., Watanabe K.,
RA   Sugiyama A., Murakawa K., Kaida T., Tsuchiya K., Fukuzumi Y.,
RA   Kumagai A., Oishi Y., Yamamoto S., Ono Y., Komori Y., Yamazaki M.,
RA   Kisu Y., Nishikawa T., Sugano S., Nomura N., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97246563; PubMed=9092801; DOI=10.1210/me.11.4.490;
RA   Hamilton J.A., Callaghan M.J., Sutherland R.L., Watts C.K.;
RT   "Identification of PRG1, a novel progestin-responsive gene with
RT   sequence homology to 6-phosphofructo-2-kinase/fructose-2,6-
RT   bisphosphatase.";
RL   Mol. Endocrinol. 11:490-502(1997).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=97292405; PubMed=9146922; DOI=10.1023/A:1018482511456;
RA   Nicholl J., Hamilton J.A., Sutherland G.R., Sutherland R.L.,
RA   Watts C.K.;
RT   "The third human isoform of 6-phosphofructo-2-kinase/fructose-2,6-
RT   bisphosphatase (PFKFB3) map position 10p14-p15.";
RL   Chromosome Res. 5:150-150(1997).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RA   Tracey A.;
RL   Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases.
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; L77662; AAL40083.1; -; mRNA.
DR   EMBL; AK291263; BAF83952.1; -; mRNA.
DR   EMBL; AL359960; CAH72164.1; -; Genomic_DNA.
DR   EMBL; AL157395; CAH72164.1; JOINED; Genomic_DNA.
DR   EMBL; AL157395; CAH73607.1; -; Genomic_DNA.
DR   EMBL; AL359960; CAH73607.1; JOINED; Genomic_DNA.
DR   EMBL; CH471072; EAW86398.1; -; Genomic_DNA.
DR   IPI; IPI00004511; -.
DR   RefSeq; NP_004557.1; -.
DR   UniGene; Hs.195471; -.
DR   SMR; Q5VX18; 35-448.
DR   STRING; Q5VX18; -.
DR   PRIDE; Q5VX18; -.
DR   Ensembl; ENST00000317350; ENSP00000369105; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000358499; ENSP00000351288; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000360521; ENSP00000353712; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379775; ENSP00000369100; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379781; ENSP00000369107; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379782; ENSP00000369108; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379784; ENSP00000369110; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379785; ENSP00000369111; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000379789; ENSP00000369115; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000414237; ENSP00000416677; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000441697; ENSP00000404995; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000444592; ENSP00000402055; ENSG00000170525; Homo sapiens.
DR   Ensembl; ENST00000450232; ENSP00000390285; ENSG00000170525; Homo sapiens.
DR   GeneID; 5209; -.
DR   KEGG; hsa:5209; -.
DR   CTD; 5209; -.
DR   HGNC; HGNC:8874; PFKFB3.
DR   HOVERGEN; Q5VX18; -.
DR   NextBio; 20146; -.
DR   ArrayExpress; Q5VX18; -.
DR   Bgee; Q5VX18; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q5VX18.
DR   SWISS-2DPAGE; Q5VX18.
KW   Hydrolase; Kinase.
SQ   SEQUENCE   520 AA;  59609 MW;  A7675A4ADC376879 CRC64;
     MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN
     WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMKVRK QCALAALRDV KSYLAKEGGQ
     IAVFDATNTT RERRHMILHF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS
     AEAMDDFMKR ISCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM
     NIHVQPRTIY LCRHGENEHN LQGRIGGDSG LSSRGKKFAS ALSKFVEEQN LKDLRVWTSQ
     LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG
     ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL
     TPVAYGCRVE SIYLNVESVC THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE
     EHVASTSAAL PSCLPPEVPT QLPGQNMKGS RSSADSSRKH
//

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