(data stored in ACNUC4932 zone)

HOVERGEN: Q5XLC3_HUMAN

ID   Q5XLC3_HUMAN            Unreviewed;       278 AA.
AC   Q5XLC3;
DT   23-NOV-2004, integrated into UniProtKB/TrEMBL.
DT   23-NOV-2004, sequence version 1.
DT   03-NOV-2009, entry version 29.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 splice isoform 4;
DE            EC=2.7.1.105;
DE            EC=3.1.3.46;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15474002; DOI=10.1016/j.febslet.2004.08.053;
RA   Minchenko O., Opentanova I., Minchenko D., Ogura T., Esumi H.;
RT   "Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-
RT   2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha
RT   activation.";
RL   FEBS Lett. 576:14-20(2004).
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; AY756063; AAV28718.1; -; mRNA.
DR   IPI; IPI00220070; -.
DR   UniGene; Hs.476217; -.
DR   SMR; Q5XLC3; 1-278.
DR   STRING; Q5XLC3; -.
DR   Ensembl; ENST00000232375; ENSP00000232375; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000383734; ENSP00000373240; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000412035; ENSP00000393047; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000416568; ENSP00000388394; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000417753; ENSP00000389169; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000422701; ENSP00000415764; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000445633; ENSP00000400772; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000452531; ENSP00000407657; ENSG00000114268; Homo sapiens.
DR   UCSC; uc003ctw.1; human.
DR   HGNC; HGNC:8875; PFKFB4.
DR   HOVERGEN; Q5XLC3; -.
DR   ArrayExpress; Q5XLC3; -.
DR   Bgee; Q5XLC3; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q5XLC3.
DR   SWISS-2DPAGE; Q5XLC3.
KW   Hydrolase; Kinase; Transferase.
SQ   SEQUENCE   278 AA;  32278 MW;  D82CE1C319B2642C CRC64;
     MRRIECYENS YESLDEDLDR DLSYIKIMDV GQSYVVNRVA DHIQSRIVYY LMNIHVTPRS
     IYLCRHGESE LNLKGRIGGD PGLSPRGREF AKSLAQFISD QNIKDLKVWT SQMKRTIQTA
     EALGVPYEQW KVLNEIDAGV CEEMTYEEIQ DNYPLEFALR DQDKYRYRYP KGESYEDLVQ
     RLEPVIMELE RQENVLVICH QAVMRCLLAY FLDKAAEQLP YLKCPLHTVL KLTPVAYGCK
     VESIFLNVAA VNTHRDRPQN VDISRPPEEA LVTVPAHQ
//

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