(data stored in ACNUC4932 zone)

HOVERGEN: Q64EX5_HUMAN

ID   Q64EX5_HUMAN            Unreviewed;       435 AA.
AC   Q64EX5;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   03-NOV-2009, entry version 33.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 4 splice isoform 3;
DE            EC=2.7.1.105;
DE            EC=3.1.3.46;
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase-4 isoform 2;
DE            EC=2.7.1.105;
DE            EC=3.1.3.46;
GN   Name=PFKFB4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Minchenko O.H., Opentanova I.L., Minchenko D.O., Ogura T., Esumi H.;
RT   "Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-
RT   2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha
RT   activation.";
RL   FEBS Lett. 0:0-0(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RA   Minchenko O.H., Opentanova I.L., Minchenko D.O., Kurashima Y.,
RA   Esumi H.;
RT   "Alternative splicing of human 6-phosphofructo-2-kinase/fructose-2,6-
RT   phosphatase 4 in melanoma cells.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Minchenko O.H., Opentanova I.L., Minchenko D.O.;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15474002; DOI=10.1016/j.febslet.2004.08.053;
RA   Minchenko O., Opentanova I., Minchenko D., Ogura T., Esumi H.;
RT   "Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-
RT   2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha
RT   activation.";
RL   FEBS Lett. 576:14-20(2004).
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; AY714243; AAU14998.1; -; mRNA.
DR   EMBL; AY756062; AAV28717.1; -; mRNA.
DR   IPI; IPI00220070; -.
DR   UniGene; Hs.476217; -.
DR   SMR; Q64EX5; 4-435.
DR   STRING; Q64EX5; -.
DR   Ensembl; ENST00000232375; ENSP00000232375; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000383734; ENSP00000373240; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000412035; ENSP00000393047; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000416568; ENSP00000388394; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000417753; ENSP00000389169; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000422701; ENSP00000415764; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000445633; ENSP00000400772; ENSG00000114268; Homo sapiens.
DR   Ensembl; ENST00000452531; ENSP00000407657; ENSG00000114268; Homo sapiens.
DR   HGNC; HGNC:8875; PFKFB4.
DR   HOVERGEN; Q64EX5; -.
DR   ArrayExpress; Q64EX5; -.
DR   Bgee; Q64EX5; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:EC.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004331; F:fructose-2,6-bisphosphate 2-phosphatase act...; IEA:EC.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q64EX5.
DR   SWISS-2DPAGE; Q64EX5.
KW   Hydrolase; Kinase; Transferase.
SQ   SEQUENCE   435 AA;  50203 MW;  814E51B938C76DA4 CRC64;
     MTNCPTLIVM VGLPARGKTY ISKKLTRYLN WIGVPTREFN VGQYRRDVVK TYKSFEFFLP
     DNEEGLKIRK QCALAALRDV RRFLSEEGGH VAVFDATNTT RERRATIFNF GEQNGYKTFF
     VESICVDPEV IAANIVQVKL GSPDYVNRDS DEATEDFMRR IECYENSYES LDEDLDRDLS
     YIKIMDVGQS YVVNRVADHI QSRIVYYLMN IHVTPRSIYL CRHGESELNL KGRIGGDPGL
     SPRGREFAKS LAQFISDQNI KDLKVWTSQM KRTIQTAEAL GVPYEQWKVL NEIDAGVCEE
     MTYEEIQDNY PLEFALRDQD KYRYRYPKGE SYEDLVQRLE PVIMELERQE NVLVICHQAV
     MRCLLAYFLD KAAEQLPYLK CPLHTVLKLT PVAYGCKVES IFLNVAAVNT HRDRPQNVDI
     SRPPEEALVT VPAHQ
//

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