(data stored in ACNUC1130 zone)

HOVERGEN: Q64GK4_DANRE

ID   Q64GK4_DANRE            Unreviewed;      1382 AA.
AC   Q64GK4;
DT   25-OCT-2004, integrated into UniProtKB/TrEMBL.
DT   25-OCT-2004, sequence version 1.
DT   03-NOV-2009, entry version 43.
DE   SubName: Full=C-Met receptor tyrosine kinase;
GN   Name=met;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=15342468; DOI=10.1242/dev.01374;
RA   Haines L., Neyt C., Gautier P., Keenan D.G., Bryson-Richardson R.J.,
RA   Hollway G.E., Cole N.J., Currie P.D.;
RT   "Met and Hgf signaling controls hypaxial muscle and lateral line
RT   development in the zebrafish.";
RL   Development 131:4857-4869(2004).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; AY687384; AAU34018.1; -; mRNA.
DR   IPI; IPI00496304; -.
DR   RefSeq; NP_001007125.1; -.
DR   UniGene; Dr.120756; -.
DR   UniGene; Dr.83673; -.
DR   SMR; Q64GK4; 1047-1347.
DR   STRING; Q64GK4; -.
DR   Ensembl; ENSDART00000074359; ENSDARP00000068848; ENSDARG00000070903; Danio rerio.
DR   Ensembl; ENSDART00000104456; ENSDARP00000095229; ENSDARG00000070903; Danio rerio.
DR   Ensembl; ENSDART00000104461; ENSDARP00000095234; ENSDARG00000070903; Danio rerio.
DR   GeneID; 492292; -.
DR   KEGG; dre:492292; -.
DR   CTD; 492292; -.
DR   ZFIN; ZDB-GENE-041014-1; met.
DR   HOGENOM; Q64GK4; -.
DR   HOVERGEN; Q64GK4; -.
DR   Bgee; Q64GK4; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0001889; P:liver development; IMP:ZFIN.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IMP:ZFIN.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR016201; Plexin-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR020707; Tyr_kinase_hepatocyte_GF_rcpt.
DR   InterPro; IPR008266; Tyr_prot_kinase_AS.
DR   InterPro; IPR001245; Tyr_prot_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_prot_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   PANTHER; PTHR23256:SF169; Tyr_kinase_hepatocyte_GF_rcpt; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q64GK4.
DR   SWISS-2DPAGE; Q64GK4.
KW   ATP-binding; Kinase; Membrane; Nucleotide-binding; Receptor;
KW   Transmembrane; Tyrosine-protein kinase.
SQ   SEQUENCE   1382 AA;  154243 MW;  4672CC89AB8E8547 CRC64;
     MTIHYSEAAS ILIILQSLWW GLNCQCEEPI ESSKLDLSVT YDLPYFVSDT PIQKLLEING
     TVYVGAVNRL YALSKDLKKK HEYKTGPVHE GPDCKTPTDQ CSGCENKPRN INNTNMALLM
     ETFYDLELFS CGSVGNGVCS RHVLEDGPLG AEVTCMYTKK NEGSSHGCPD CLAGPAGTQI
     LNIMSGRVVR FFVANSEPLE SNGPRLHHTI SIRKMRETQD GFEFFSEQSY MDLAPSLRGN
     YPLHYVYSFQ SGPYVYFLTV QREGGNSKAF HTRIVRMCSS DSEILRYVEM PFECIYSERR
     RKKRSAQVVF NVLQAAHVAK VGYDFQQEMG LKEGEDVLFA AFARSKPDSP EPTASSAVCL
     ISITDINEFF KVFIQKGYTR KLHHFPGSEE KTFNQTFVGD SFSCGKHERG YRLEVTSTNP
     RRDYFHGRFR NVLLTSIAVV PIQNHTVVSL GTAEGRVIQV VVSRFGKTEP HVDFRLDMLP
     VSSEMALLSP QHHNGSLLLI TGDKVSKLPV IGPGCEQLWT CSSCLLAPGF MGCGWCRTSN
     RCTRAPRCPQ SQWIQDSCPL LITSISPSSA PLRGQTNITI CGKNFGFNKK DRFDTKLVDV
     VVAGTKCKLE RKDSNNNRLV CGLDYVNWSS LDSVITVRSG KEQAQKDGFS FVNPVIIEIF
     PEFGPQSGGT MLTISGSFLD SGNVQTVTVG NATCVLQSVS ATMLTCRTPP QPSPSQHKVQ
     LHIDGVIFEA PVSYTYNKNP HISSVQPKHS FISGGSTVTV NGFYLHSALQ PQMVLTAATE
     GKLFQVTCSH DEDKRNILCI TPSLKGLSVQ PPVATKMTFV LDGFSTDQYD LLYVEDPKFE
     EFQKPTVTPR GKKNILEIKV PPVNQEAVKN GEVLRVSNRT CESVTLVGNT LECTVPMELQ
     TAAKELEVEW KQATSSVILG RVILAQDQDY RILITGGVCV SILLLLLIAV FVWIKRKKHI
     DDLAKTMVWY DGRAHIPHLD MLANARSVSP TDEMVSHESV DYRTTLLEDQ NLPLSQTESC
     RPHLYAHSHV DLSPMLGPME GDLASPLLPS TAPIDLGSLH PELLKXVQHV VIAREDLLLH
     VNEIIGRGHF GCVFHGTLLE PDGQKQHCAI KSLNRITDIE EVSQFLKEGI IVKDFSHPNV
     LSLLGICLPS EGSPLVVLPY MKHGDLRNFI RDESHNPTVK DLMGFGLQVA KGMEYLASKK
     FVHRDLAARN CMLDESYTVK VADVGLARDV YDKEYYSVHN KHGVKLPVKW MALESLQTHK
     FTTKSDVWSF GVLLWELMTR GAPPYSDVNS FDITVFLLQG RRLLQPEFCP DALYNVMIEC
     WHPKPERRPT FLELVSRISA IFSSFSGEHY ILLNTTYVNI DKMTPYPSLI SSQSNLDRDC
     CT
//

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