(data stored in ACNUC4932 zone)

HOVERGEN: Q6GTL7_MOUSE

ID   Q6GTL7_MOUSE            Unreviewed;       518 AA.
AC   Q6GTL7;
DT   10-MAY-2005, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2005, sequence version 1.
DT   03-NOV-2009, entry version 34.
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2;
DE   SubName: Full=Putative uncharacterized protein;
DE   SubName: Full=6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 2, isoform CRA_b;
GN   Name=Pfkfb2; ORFNames=mCG_2633;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed;
RX   MEDLINE=22036378; PubMed=12040188; DOI=10.1126/science.1069193;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Miklos G.L., Wides R.,
RA   Halpern A., Li P.W., Sutton G.G., Nadeau J., Salzberg S.L., Holt R.A.,
RA   Kodira C.D., Lu F., Chen L., Deng Z., Evangelista C.C., Gan W.,
RA   Heiman T.J., Li J., Li Z., Merkulov G.V., Milshina N.V., Naik A.K.,
RA   Qi R., Shue B.C., Wang A., Wang J., Wang X., Yan X., Ye J.,
RA   Yooseph S., Zhao Q., Zheng L., Zhu S.C., Biddick K., Bolanos R.,
RA   Delcher A.L., Dew I.M., Fasulo D., Flanigan M.J., Huson D.H.,
RA   Kravitz S.A., Miller J.R., Mobarry C.M., Reinert K., Remington K.A.,
RA   Zhang Q., Zheng X.H., Nusskern D.R., Lai Z., Lei Y., Zhong W., Yao A.,
RA   Guan P., Ji R.R., Gu Z., Wang Z.Y., Zhong F., Xiao C., Chiang C.C.,
RA   Yandell M., Wortman J.R., Amanatides P.G., Hladun S.L., Pratts E.C.,
RA   Johnson J.E., Dodson K.L., Woodford K.J., Evans C.A., Gropman B.,
RA   Rusch D.B., Venter E., Wang M., Smith T.J., Houck J.T., Tompkins D.E.,
RA   Haynes C., Jacob D., Chin S.H., Allen D.R., Dahlke C.E., Sanders R.,
RA   Li K., Liu X., Levitsky A.A., Majoros W.H., Chen Q., Xia A.C.,
RA   Lopez J.R., Donnelly M.T., Newman M.H., Glodek A., Kraft C.L.,
RA   Nodell M., Ali F., An H.J., Baldwin-Pitts D., Beeson K.Y., Cai S.,
RA   Carnes M., Carver A., Caulk P.M., Center A., Chen Y.H., Cheng M.L.,
RA   Coyne M.D., Crowder M., Danaher S., Davenport L.B., Desilets R.,
RA   Dietz S.M., Doup L., Dullaghan P., Ferriera S., Fosler C.R.,
RA   Gire H.C., Gluecksmann A., Gocayne J.D., Gray J., Hart B., Haynes J.,
RA   Hoover J., Howland T., Ibegwam C., Jalali M., Johns D., Kline L.,
RA   Ma D.S., MacCawley S., Magoon A., Mann F., May D., McIntosh T.C.,
RA   Mehta S., Moy L., Moy M.C., Murphy B.J., Murphy S.D., Nelson K.A.,
RA   Nuri Z., Parker K.A., Prudhomme A.C., Puri V.N., Qureshi H.,
RA   Raley J.C., Reardon M.S., Regier M.A., Rogers Y.H., Romblad D.L.,
RA   Schutz J., Scott J.L., Scott R., Sitter C.D., Smallwood M.,
RA   Sprague A.C., Stewart E., Strong R.V., Suh E., Sylvester K.,
RA   Thomas R., Tint N.N., Tsonis C., Wang G., Wang G., Williams M.S.,
RA   Williams S.M., Windsor S.M., Wolfe K., Wu M.M., Zaveri J.,
RA   Chaturvedi K., Gabrielian A.E., Ke Z., Sun J., Subramanian G.,
RA   Venter J.C., Pfannkoch C.M., Barnstead M., Stephenson L.D.;
RT   "A comparison of whole-genome shotgun-derived mouse chromosome 16 and
RT   the human genome.";
RL   Science 296:1661-1671(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Mixed;
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group
RG   (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266;
RA   Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S.,
RA   Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H.,
RA   Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.,
RA   Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J.,
RA   Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W.,
RA   Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S.,
RA   Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S.,
RA   Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J.,
RA   Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D.,
RA   Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L.,
RA   Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A.,
RA   Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H.,
RA   Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G.,
RA   Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S.,
RA   Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M.,
RA   Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K.,
RA   Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M.,
RA   Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C.,
RA   Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L.,
RA   Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N.,
RA   Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K.,
RA   Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S.,
RA   Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I.,
RA   Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A.,
RA   Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J.,
RA   Birney E., Hayashizaki Y.;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   MEDLINE=21085660; PubMed=11217851; DOI=10.1038/35055500;
RA   Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y.,
RA   Arakawa T., Hara A., Fukunishi Y., Konno H., Adachi J., Fukuda S.,
RA   Aizawa K., Izawa M., Nishi K., Kiyosawa H., Kondo S., Yamanaka I.,
RA   Saito T., Okazaki Y., Gojobori T., Bono H., Kasukawa T., Saito R.,
RA   Kadota K., Matsuda H.A., Ashburner M., Batalov S., Casavant T.,
RA   Fleischmann W., Gaasterland T., Gissi C., King B., Kochiwa H.,
RA   Kuehl P., Lewis S., Matsuo Y., Nikaido I., Pesole G., Quackenbush J.,
RA   Schriml L.M., Staubli F., Suzuki R., Tomita M., Wagner L., Washio T.,
RA   Sakai K., Okido T., Furuno M., Aono H., Baldarelli R., Barsh G.,
RA   Blake J., Boffelli D., Bojunga N., Carninci P., de Bonaldo M.F.,
RA   Brownstein M.J., Bult C., Fletcher C., Fujita M., Gariboldi M.,
RA   Gustincich S., Hill D., Hofmann M., Hume D.A., Kamiya M., Lee N.H.,
RA   Lyons P., Marchionni L., Mashima J., Mazzarelli J., Mombaerts P.,
RA   Nordone P., Ring B., Ringwald M., Rodriguez I., Sakamoto N.,
RA   Sasaki H., Sato K., Schoenbach C., Seya T., Shibata Y., Storch K.-F.,
RA   Suzuki H., Toyo-oka K., Wang K.H., Weitz C., Whittaker C., Wilming L.,
RA   Wynshaw-Boris A., Yoshida K., Hasegawa Y., Kawaji H., Kohtsuki S.,
RA   Hayashizaki Y.;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [9]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [10]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RX   MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [11]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Stomach;
RA   Arakawa T., Carninci P., Fukuda S., Hashizume W., Hayashida K.,
RA   Hori F., Iida J., Imamura K., Imotani K., Itoh M., Kanagawa S.,
RA   Kawai J., Kojima M., Konno H., Murata M., Nakamura M., Ninomiya N.,
RA   Nishiyori H., Nomura K., Ohno M., Sakazume N., Sano H., Sasaki D.,
RA   Shibata K., Shiraki T., Tagami M., Tagami Y., Waki K., Watahiki A.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; BC051014; AAH51014.1; -; mRNA.
DR   EMBL; AK146744; BAE27404.1; -; mRNA.
DR   EMBL; CH466520; EDL39734.1; -; Genomic_DNA.
DR   EMBL; CH466520; EDL39736.1; -; Genomic_DNA.
DR   IPI; IPI00556828; -.
DR   RefSeq; NP_001155887.1; -.
DR   RefSeq; NP_001155888.1; -.
DR   RefSeq; NP_032851.2; -.
DR   UniGene; Mm.249861; -.
DR   STRING; Q6GTL7; -.
DR   Ensembl; ENSMUST00000066863; ENSMUSP00000066426; ENSMUSG00000026409; Mus musculus.
DR   GeneID; 18640; -.
DR   KEGG; mmu:18640; -.
DR   UCSC; uc007cme.1; mouse.
DR   CTD; 18640; -.
DR   MGI; MGI:107815; Pfkfb2.
DR   HOVERGEN; Q6GTL7; -.
DR   OMA; HPRTIYL; -.
DR   NextBio; 294622; -.
DR   ArrayExpress; Q6GTL7; -.
DR   Bgee; Q6GTL7; -.
DR   Genevestigator; Q6GTL7; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6GTL7.
DR   SWISS-2DPAGE; Q6GTL7.
KW   Kinase.
SQ   SEQUENCE   518 AA;  59816 MW;  8B2384BE1F4CC798 CRC64;
     MSENSTFSPE DCNSSYKPHA SNLRRAGKTC SWASYMTNSP TLIVMIGLPA RGKTYVSKKL
     TRYLNWIGVP TKVFNLGVYR REAVKSYQSY DFFRHDNEEA MKIRKQCALV ALEDVKAYFT
     EESGQIAVFD ATNTTRERRD MILNFAKQNA FKVFFVESVC DDPDVIAANI LEVKVSSPDY
     PERNRENVME DFLKRIECYK VTYQPLDPDN YDKDLSFIKV INVGQRFLVN RVQDYIQSKI
     VYYLMNIHVH PRTIYLCRHG ESEFNLLGKI GGDSGLSVRG KQFAHALKKF LEEQEIQDLK
     VWTSQLKRTI QTAESLGVTY EQWKILNEID AGVCEEMTYS EIEQRYPEEF ALRDQEKYLY
     RYPGGESYQD LVQRLEPVIM ELERQGNILV ISHQAVMRCL LAYFLDKGAD ELPYLRCPLH
     IIFKLTPVAY GCKVETITLN VDAVDTHRDK PTHNFPKSQT PVRMRRNSFT PLSSSNTIRR
     PRNYSVGSRP LKPLSPLRAL DMQEGADQPK TQVSIPVV
//

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