(data stored in ACNUC6163 zone)

HOVERGEN: Q6UQ17_MOUSE

ID   Q6UQ17_MOUSE            Unreviewed;      1335 AA.
AC   Q6UQ17;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   03-NOV-2009, entry version 55.
DE   SubName: Full=ATPase, class I, type 8B, member 3;
DE   SubName: Full=SAPLT;
GN   Name=Atp8b3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ICR; TISSUE=Testes;
RX   PubMed=14975727; DOI=10.1016/j.ydbio.2003.11.004;
RA   Wang L., Beserra C., Garbers D.L.;
RT   "A novel aminophospholipid transporter exclusively expressed in
RT   spermatozoa is required for membrane lipid asymmetry and normal
RT   fertilization.";
RL   Dev. Biol. 267:203-215(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=PCR rescued clones;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP +
CC       phosphate + phospholipid(Out).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
CC   -!- GENE_FAMILY: HBG050601 [ FAMILY / ALN / TREE ]
DR   EMBL; BC118977; AAI18978.1; -; mRNA.
DR   EMBL; AY364445; AAR12913.1; -; mRNA.
DR   IPI; IPI00411056; -.
DR   RefSeq; NP_080370.2; -.
DR   UniGene; Mm.52511; -.
DR   PhosphoSite; Q6UQ17; -.
DR   Ensembl; ENSMUST00000020383; ENSMUSP00000020383; ENSMUSG00000003341; Mus musculus.
DR   Ensembl; ENSMUST00000060793; ENSMUSP00000057789; ENSMUSG00000003341; Mus musculus.
DR   GeneID; 67331; -.
DR   KEGG; mmu:67331; -.
DR   UCSC; uc007gdo.1; mouse.
DR   CTD; 67331; -.
DR   MGI; MGI:1914581; Atp8b3.
DR   HOGENOM; Q6UQ17; -.
DR   HOVERGEN; Q6UQ17; -.
DR   OMA; RVYQVLA; -.
DR   NextBio; 324260; -.
DR   ArrayExpress; Q6UQ17; -.
DR   Bgee; Q6UQ17; -.
DR   Genevestigator; Q6UQ17; -.
DR   GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000299; C:integral to membrane of membrane fraction; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004012; F:phospholipid-translocating ATPase activity; IMP:MGI.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   GO; GO:0007339; P:binding of sperm to zona pellucida; IMP:MGI.
DR   GO; GO:0045332; P:phospholipid translocation; IMP:MGI.
DR   InterPro; IPR008250; ATPase_P-typ_ATPase-assoc-reg.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006539; ATPase_P-typ_Plipid-transl.
DR   InterPro; IPR013200; HAD-SF_hydro-like_3.
DR   PANTHER; PTHR11939; ATPase_P; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF08282; Hydrolase_3; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 2.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6UQ17.
DR   SWISS-2DPAGE; Q6UQ17.
KW   ATP-binding; Hydrolase; Magnesium; Membrane; Nucleotide-binding;
KW   Transmembrane.
FT   DOMAIN        1     44       PRODOM:2005.1:PD867486  6
FT   DOMAIN       45     78       PRODOM:2005.1:PD584476  133
FT   DOMAIN       81    167       PRODOM:2005.1:PD583714  159
FT   DOMAIN      168    218       PRODOM:2005.1:PD111436  109
FT   DOMAIN      219    272       PRODOM:2005.1:PD004982  138
FT   DOMAIN      273    354       PRODOM:2005.1:PD006317  109
FT   DOMAIN      362    389       PRODOM:2005.1:PD876157  42
FT   DOMAIN      390    431       PRODOM:2005.1:PD864285  143
FT   DOMAIN      468    532       PRODOM:2005.1:PD003346  121
FT   DOMAIN      552    591       PRODOM:2005.1:PD461286  88
FT   DOMAIN      600    644       PRODOM:2005.1:PD250570  129
FT   DOMAIN      646    677       PRODOM:2005.1:PD336512  128
FT   DOMAIN      678    705       PRODOM:2005.1:PD030421  130
FT   DOMAIN      745    831       PRODOM:2005.1:PD886883  3
FT   DOMAIN      851    888       PRODOM:2005.1:PD005736  137
FT   DOMAIN      892    935       PRODOM:2005.1:PD435496  137
FT   DOMAIN      936    982       PRODOM:2005.1:PD304524  143
FT   DOMAIN      983   1032       PRODOM:2005.1:PDA030Z2  11
FT   DOMAIN     1033   1098       PRODOM:2005.1:PD804980  3
FT   DOMAIN     1100   1189       PRODOM:2005.1:PD180313  12
FT   DOMAIN     1190   1335       PRODOM:2005.1:PDA0Y778  1
SQ   SEQUENCE   1335 AA;  151955 MW;  7674AA921B28EE35 CRC64;
     MDGVHLGENL EDKDTEFTWE VKANDRTYHK QFKKKGFLCW RQKKYKSNAI HTAKYNIFSF
     LPLNLYEQFH RMSNLYFLFI IILQGIPEIS TLPWFTLFAP LVCLFVIRAT RDLVDDIGRH
     RSDKIINNRP CQILRGKSFL WKKWKNLCVG DVVCLSKDSI VPADLLLLAS TEPSSLCYVE
     TADIDGETNL KFRQALTVTH HELTSPKKMA SFQGTVTCEE PNSRMHHFVG SLEWNSRKYP
     LDIGNLLLRG CKIRNTDTCY GLVIYAGLDT KIMKNCGKIH LKRTKLDLMM NKLVALIFLS
     LVIASLLLTV GFTFMVKQFK AKHYYMSPTH GRSDAMESFF IFWGFLILLS VMVPMAMFII
     AEFIYLGNSI FINWDLNMYY EPLDMPAKAR STSLNDQLGQ VQYIFSDKTG TLTQNIMTFK
     KCCINGCIYD SDDEHGTLRK RNPYAWNPFA DGKLQFYNKE LESLVQGRQD RAVQEFWRLL
     AICHTVMVQE KDNQLLYQAA SPDEEALVTA ARNFGYVFLS RTQDTITLVE LGEERVYQVL
     AMMDFNSVRK RMSVLVRNPE GSICLYTKGA DTVILERLRS KGVMEATTEE VLAAFAEQTL
     RTLCLAYKDV EEDAYKEWEP EHQEAALLLQ NRAQALHQVY NKMEQNLQLL GATAIEDKLQ
     DGVPETIKCL KKGNIKIWVL TGDKPETAVN IGFACQLLSE NMIILEDKDI NQVLERYWED
     NVHQKAFKMM THHNMALVIN GEFLDQLLLS LRKEPRALVQ NAVVDEVAQE PVVSALDFLQ
     KRRISQMWRN AGPSLGTSHS ADSKIRESPE VQRERAFVDL ASKCQAVICC RVTPKQKALV
     VALVKKYQQV VTLAIGDGAN DVNMIKTADI GVGLAGQEGM QAVQNSDYVL AQFCYLQRLL
     LVHGRWSYMR VCKFLRYFFY KTVASMMAQI WFSLVNGFSA QPLYEGWFLA LFNLLYSTLP
     VLYIGLFEQD VTAEKSLKMP ELYMAGQKGE LFNYSIFMQA ITHGTITSMI NFFVTVMVSS
     DMSKAGSSHD YQSLGVLVAI SSLLSVTLEV MLVVKYWTLL FVGAVVLSLS SYVLMTSLTQ
     SLWMYRISPK TFPFLFADYN VLFEPCSLLL IVLNVALNVL PMLALRTIHR TVLKQRPKGE
     EEAPSEEVAV EPAMRHLRRG IPARRSSYAF SHREGYANLI TQGTILRRQT HVDDSDGGTV
     CESLNPPEED IPLQNKDSVF NPRKISILAK KRRHFFGKGS QEEVHPNTSS QTMEKQPTIH
     RDSETQKLPT TTSATSGKLL PSASEDEAFY SVASQYTLAS QPKHTDVHSS FWKSPLWRDS
     ASSSPSQLEV PRKQS
//

If you have problems or comments...

PBIL Back to PBIL home page